Envisaging an Effective Global Long-Term Agrobiodiversity Conservation System That Promotes and Facilitates Use

Genebanks were established out of a recognised need not just to provide genetic variation to support breeding objectives but to prevent crop diversity from being lost entirely for future users. Such conservation objectives may have led, over the past few decades, to a gradually diminishing connection between genebanks and current users of diversity. While there continues to be large-scale distribution of germplasm from genebanks to recipients worldwide, relatively little is known or published about the detailed trends in the demand for genebank materials. Meanwhile, the rapid expansion of the applications and uses of modern genomic technologies and approaches is, undoubtedly, having a transformational impact on breeding, research and the demand for certain genetic resources and associated data. These trends will require genebanks to be responsive and to adapt. They also provide important opportunities for genebanks to reorganize and become more efficient individually and as a community. Ultimately, future challenges and opportunities are likely to drive more demand for genetic diversity and provide an important basis for genebanks to gear up.

Brazil presidential hopefuls gear up for 2022 election

Significance In recent weeks, former Justice Minister Sergio Moro has joined a centre-right party, Sao Paulo Governor Joao Doria has won his party’s presidential primaries and former President Luis Inacio Lula da Silva, widely seen as Bolsonaro’s main competitor, has completed a successful European tour. Bolsonaro has joined a new party ahead of the election. Impacts Bolsonaro will keep pushing for congressional approval of his pre-election spending measures to improve his prospects. The incumbent will increase his attacks on Lula and 'third-way' candidates, emulating the 2018 presidential campaign. Lula will seize any opportunity to consolidate himself as the focus of opposition to Bolsonaro for both the left and centre.

Excess Fuel Consumption Due to Selection of a Lower Than Optimal Gear—Case Study Based on Data Obtained in Real Traffic Conditions

Appropriate driving technique, in compliance with eco-driving principles, remains an effective method to reduce fuel consumption. The selection of the correct gear is one of the pertinent factors when driving a car with a manual gearbox. In this study we have analyzed fuel overconsumption based on data recorded in real traffic conditions for vehicles driven by experienced drivers, using a black-box model. It was found that the total share of trip time with a lower than optimal gear selected amounted to from c.a. 3% for motorway driving up to 28% on rural roads. The mean fuel consumption reduction factor (following selection of the next gear up) amounted to from c.a. 2% up to 20%, depending on the selected gear and type of driving. Unfortunately, the potential for reduction of fuel consumption is not evenly distributed over the entire operating area of the engine. Thus, the cumulative reduction of fuel consumption, due to selection of the optimal gear, amounted to from c.a. 0.2% for motorway driving up to 3–6%, for urban and rural driving. It was shown that due to the selection of the appropriate gear, there still exists a real possibility of reduction of fuel consumption, even in the case of experienced drivers.

2020

Chapter 7 provides a look into CWG prior to and after the 2020 election, as well as interviews with several group members prior to the election results. Through this data, this chapter explores how CWG and its members grappled with a global pandemic, a national reckoning around racial injustice, and the gear-up to an unprecedented presidential election. The women of CWG had closed out 2019 with optimism. In looking to their efforts for the 2020 election, the women promised to make “voter education” a priority—continuing their outreach and exploring new ways of reaching possible Democrats in the area. This chapter considers how 2020 reflects the same realities as the years before it and how it presents new challenges regarding if and how people express their political beliefs.

LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1

Background Emerging studies have shown that long noncoding RNAs (lncRNAs) predominantly function in the carcinogenesis of multiple developing human tumors. The current study aimed to investigate the underlying mechanisms of LINC00337 in lung adenocarcinoma. Methods We analyzed TCGA and GTEx datasets and chose LINC00337 as the research object. Cell proliferation, cell apoptosis, cell cycle, migration, and invasion were detected in the gain and loss experiments of LINC00337 both in vitro and in vivo. Moreover, RNA pull-down, luciferase reporter assays, western blotting analysis, and rescue experiments were performed to investigate the underlying molecular mechanisms of LINC00337 function. Results LINC00337 expression was remarkably upregulated in lung adenocarcinoma. In addition, LINC00337 knockdown was shown to repress cell migration, invasion, and proliferation, as well as the cell cycle, and gear up apoptosis in lung adenocarcinoma in vitro and in vivo. With respect to the mechanism, LINC00337 knockdown boosted miR-1285-3p expression and then restrained YTHDF1 expression post-transcriptionally. Crucially, both miR-1285-3p decrement and YTHDF1 overexpression successfully reversed the influence on cell proliferation, migration, invasion, and apoptosis caused by LINC00337 shRNA. Conclusions These results suggest that LINC00337 acts as an oncogenic lncRNA, targeting miR-1285-3p and regulating YTHDF1 expression, to promote the progression of lung adenocarcinoma.

Opportunities to promote human rights and democratic values abroad: The case of Canadian foreign policy toward Venezuela

This article examines Canadian foreign policy toward Venezuela, as a litmus test of Ottawa’s promise to project a consistently strong voice for the protection of human rights and the advancement of democratic values in the world. The case is made that Canada is more likely to gear up to an assertive approach if there is a perception that there is an opportunity for democratization in the country, and for policymakers in Ottawa, if there is an opportunity to prioritize human rights and democracy, as opposed to more traditional national interest objectives. The article offers an explanation about when and how Canada typically promotes its liberal values abroad.

Effect of Consumers’ Immunity Consciousness on Monthly Consumption of Immunity Booster Products

Recent times have witnessed a considerable inclination of consumers towards the ongoing trend pointing to buy immunity products. This trend is seen to gear up during last few years. Availability of a wide range of immunity booster products has given a lot of choices to the customers to purchase. One of the important reasons that people have started exploring health products is because of their belief that healthy eating habits will boost their immunity, can provide health benefits and can also protect them from any virus infections. An in-depth analysis has been done over a sample of 208 respondents from various age groups under working and non-working categories to determine their awareness and inclination to buy immunity-based products. Statistical analysis carried out over the collected data shows that working people are more immunity conscious than the non-working people because they consume more immunity products monthly than non-working people. The amount spent by working people towards the purchase of immunity products is more than non-working people which proves their health consciousness.

Iraqi political forces gear up for post-poll deals

Headline IRAQ: Political forces gear up for post-poll deals

Regional Model Bit’s : A New Down For the Developing Countries

Foreign direct investment (FDI) plays a crucial role in the economic sector, particularly in developing countries. BIT lays down instrumental principles which help to protect investors’ establishments in host states, by inter alia encouraging prompt compensation in case of expropriation. Governments need FDIs to gear up their economic growth, advance technology, and scale down unemployment. Most scholarly writings are in favor that BIT is a necessary tool for promoting FDIs, however this study takes a different approach and categorically unveils the draw backs of BIT in developing countries by highlighting some of the contentious provisions that have sparked unprecedented legal, economic, sociopolitical and diplomatic strife between the host countries, investors and investors’ home countries. Therefore, the author proposes development for regional Model BITs that would go in line with national laws to curtail the persisting sovereignty and socio-economic challenges.