Blood pressure-lowering effects of extended-release niacin alone and extended-release niacin/laropiprant combination: A post hoc analysis of a 24-week, placebo-controlled trial in dyslipidemic patients

2009 ◽  
Vol 31 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Harold E. Bays ◽  
Darbie Maccubbin ◽  
Alan G. Meehan ◽  
Olga Kuznetsova ◽  
Yale B. Mitchel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Extended Release ◽  
Controlled Trial ◽  
Blood Pressure Lowering ◽  
Post Hoc Analysis ◽  
Pressure Lowering ◽  
Post Hoc

scholarly journals Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial

2004 ◽  
Vol 92 (4) ◽  
pp. 701-706 ◽  
Author(s):  
Beate Turner ◽  
Christian Mølgaard ◽  
Peter Marckmann
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Allium Sativum ◽  
Blood Lipids ◽  
Controlled Trial ◽  
Lipid Lowering ◽  
Blood Pressure Lowering ◽  
Double Blind ◽  
Garlic Powder ◽  
Pressure Lowering

Recent studies have cast doubt on the proposed lipid-lowering and blood pressure-lowering effects of garlic. We tested the effect of dried garlic (Allium sativum) powder on blood lipids, blood pressure and arterial stiffness in a 12-week randomised, double-blind, placebo-controlled trial. Seventy-five healthy, normo-lipidaemic volunteers (men and women aged 40–60 years) were assigned to dried garlic powder tablets (10·8 mg alliin (3-(2-propenylsulfinyl)-l-alanine)/d, corresponding to about three garlic cloves) or placebo. Sixty-two subjects were eligible for the per-protocol analysis. The primary outcome measure was serum total cholesterol concentration. Secondary outcome measures were LDL-cholesterol, HDL-cholesterol and triacylglycerol concentrations, blood pressure and arterial stiffness (assessed by pulse wave velocity). No significant differences between the garlic and placebo groups were detected for any of the outcome measures. However, garlic powder was associated with a near-significant decrease (12 %) in triacylglycerol concentration (P=0·07). In conclusion, garlic powder tablets have no clinically relevant lipid-lowering and blood pressure-lowering effects in middle-aged, normo-lipidaemic individuals. The putative anti-atherosclerotic effect of garlic may be linked to risk markers other than blood lipids.

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