A Cross-Sectional Study of Myelodysplastic Syndrome in a Brazilian Population

Abstract Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. Methods This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. Clinical presentations, complete blood counts (CBC), and bone marrow (BM) biopsy samples were assessed. Perls' staining was used to evaluate BM iron storage. The cytogenetic evaluation was performed using the conventional G banding method on the BM. Results Patients’ median age was 62.3 (ranged from 50–76), and the majority were male (72.8%). The most common clinical symptom at the time of admission was fatigue (n = 33) followed by pallor (n = 27). The most common subgroup was MDS-Multi Lineage Dysplasia (MDS-MLD) (n = 38, 36.8%), followed by MDS-Single Lineage Dysplasia (MDS-SLD) (n = 28, 18.4%). A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by dell 17p (n = 9) and monosomy 7 (-7) (n = 7). Twelve patients (11.65 %) were transformed to AML. Conclusion Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. Noteworthy, the male: female ratio was slightly higher in Iran than in previous reports from other parts of the world. Our study is the first report of the clinical, hematological, and cytogenetic spectrum of MDS patients in Iran

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Social determinants and other aspects associated with rheumatic diseases in the Brazilian population: a cross-sectional study based on the National Health Survey (PNS2013).

10.21203/rs.3.rs-54565/v2 ◽

2020 ◽

Author(s):

Clécio Gabriel Souza ◽

Marcelo Cardoso Souza ◽

Hugo Jario Silva ◽

Sanderson Assis ◽

Diego Sousa Dantas

Keyword(s):

Physical Activity ◽

Rheumatic Diseases ◽

Social Factors ◽

Cross Sectional Study ◽

National Health Survey ◽

Brazilian Population ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

The Social

Abstract Background: Rheumatic diseases are increasingly present in the world population, represented by chronic joint and musculoskeletal pain. Among them, osteoarthritis (OA) is the most prevalent. It is considered the third most prevalent chronic non-communicable disease in the Brazilian population, being responsible for a high rate of physical disability and reduced quality of life. Little has been discussed about the social factors associated with this health condition. This study aimed to analyze the social factors associated with arthritis in the Brazilian population.Methods: This is a cross-sectional study based on data from the 2013 National Health Survey in Brazil with arthritis as its main outcome. Sex, age, body weight, usual activities, physical activity, self-perceived health and diagnosis of depression were analyzed as independent variables. Descriptive and inferential statistics were used. Poisson multiple regression was performed, and the prevalence ratio (PR) and confidence interval (CI) of 95% were calculated using a significance level of 5% (p≤0.05).Results: A total of 60,202 individuals of both sexes took part in this study and the rheumatic diseases or arthrtitis prevalence was 6.4%. The individual factors associated with a higher prevalence of arthritis were female (PR = 2.09; CI = 1.95-2.25), age over 35 years (PR = 2.88; CI = 2.57-3.24) and excess body weight (PR = 1.61; CI = 1.25-2.07). The presence of rhemautic diseases showed an association with lower performance of usual activities (PR = 1.61; CI = 1.50-1.73) and self-perceived health as very poor (PR = 3.96; CI = 3.31-4.72). In addition, it was associated with a higher prevalence of mental illnesses such as depression (PR = 1.77; CI = 1.64-1.90).Conclusion: Social and modifiable factors which are associated with a higher prevalence of arthritis can be controlled through incentive measures such as social participation and physical activity.

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Analysis of Social Aspects Associated with Osteoarthritis in the Brazilian Population: A Cross-sectional Study Based on the National Health Survey in Brazil (PNS 2013).

10.21203/rs.3.rs-54565/v1 ◽

2020 ◽

Author(s):

Clécio Gabriel Souza ◽

Marcelo Cardoso Souza ◽

Hugo Jario Silva ◽

Sanderson Assis ◽

Diego Sousa Dantas

Keyword(s):

Physical Activity ◽

Body Weight ◽

Social Factors ◽

Cross Sectional Study ◽

National Health Survey ◽

Brazilian Population ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

The Social

Abstract Background: Osteoarthritis (OA) is considered the third most prevalent chronic non-communicable disease in the Brazilian population, being responsible for a high rate of physical disability and reduced quality of life. Little has been discussed about the social factors associated with this health condition. This study aimed to analyze the social factors associated with OA in the Brazilian population. Methods: This is a cross-sectional study based on data from the 2013 National Health Survey in Brazil with OA as its main outcome. Gender, age, body weight, usual activities, physical activity, self-perceived health and diagnosis of depression were analyzed as independent variables. Descriptive and inferential statistics were used. Poisson multiple regression was performed, and the prevalence ratio (PR) and confidence interval (CI) of 95% were calculated using a significance level of 5% (p≤0.05). Results: A total of 60,202 individuals of both genders took part in this study and the OA prevalence was 6.4%. The individual factors associated with a higher prevalence of OA were female gender (PR = 2.09; CI = 1.95-2.25), age over 35 years (PR = 2.88; CI = 2.57-3.24) and excess body weight (PR = 1.61; CI = 1.25-2.07). The presence of OA showed an association with lower performance of usual activities (PR = 1.61; CI = 1.50-1.73) and self-perceived health as very poor (PR = 3.96; CI = 3.31-4.72). In addition, it was associated with a higher prevalence of mental illnesses such as depression (PR = 1.77; CI = 1.64-1.90). Conclusion: Social and modifiable factors which are associated with a higher prevalence of osteoarthritis can be controlled through incentive measures such as social participation and physical activity.

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Multiple Roots and Canals in Mandibular Canines and Premolars in a Brazilian Population: A Cross Sectional Study Using CBCT and Panoramic Radiography

International Journal of Advanced Engineering Research and Science ◽

10.22161/ijaers.712.32 ◽

2020 ◽

Vol 7 (12) ◽

pp. 210-216

Author(s):

Erick Carvalho Mendez ◽

Ana Grasiela da Silva Limoeiro ◽

Tatiana Dantas Piana

Keyword(s):

Panoramic Radiography ◽

Cross Sectional Study ◽

Brazilian Population ◽

Multiple Roots ◽

Sectional Study ◽

Cross Sectional

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Early Markers of Cardiovascular Disease Associated With Clinical Data and Autosomal Ancestry in Patients With Type 1 Diabetes: A Cross-sectional Study in an Admixed Brazilian Population.

10.21203/rs.3.rs-1215441/v1 ◽

2022 ◽

Author(s):

Roberta Maria Duailibe Ferreira Reis Reis ◽

Dayse Aparecida Silva ◽

Maria da Glória Tavares ◽

Gilvan Cortês Nascimento ◽

Sabrina da Silva Pereira Damianse ◽

...

Keyword(s):

Cardiovascular Disease ◽

Type 1 Diabetes ◽

Young Patients ◽

Cross Sectional Study ◽

Brazilian Population ◽

Sectional Study ◽

Cross Sectional ◽

Early Markers ◽

Carotid Doppler

Abstract BackgroundPatients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. The objective of this study was to investigate early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. MethodsA cross-sectional study was conducted with 99 T1D patients. The early markers of CVD included the ankle-brachial index (ABI), coronary artery calcium score (CACS), and carotid Doppler sonography. Demographic, clinical, and serum data were collected. A panel of autosomal informational insertion/deletion ancestry markers was used to estimate the individual proportions of European, African, and Amerindian ancestry.ResultsThe study sample had a mean age of 27.6 years and 14.4 years of duration of T1D. The prevalence of alterations in early CVD markers was: ABI (< 0,9) 19.6%, CACS (> 0 +) 4.1%, and carotid Doppler 5.0%. There was significant agreement between CACS and carotid Doppler, and these were correlated with traditional risk factors for CVD. There was a predominance of European ancestry (47.3%), followed by African (28%) and Ameridian (24.7%). There were no association between early CVD markers and autosomal ancestry proportions.ConclusionThe ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease, and showed agreement with the carotid Doppler. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population.

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Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients

Molecular Cytogenetics ◽

10.1186/s13039-021-00548-z ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Mostafa Paridar ◽

Kazem Zibara ◽

Seyed Esmaeil Ahmadi ◽

Abbas Khosravi ◽

Maral Soleymani ◽

...

Keyword(s):

Myelodysplastic Syndrome ◽

Cross Sectional Study ◽

Cytogenetic Abnormality ◽

Sectional Study ◽

Trisomy 8 ◽

Cross Sectional ◽

Iron Storage ◽

Monosomy 7 ◽

Female Ratio ◽

Cytogenetic Abnormalities

Abstract Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. Methods This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. Clinical presentations, complete blood counts (CBC), and bone marrow (BM) biopsy samples were assessed. Perls' staining was used to evaluate BM iron storage. The cytogenetic evaluation was performed using the conventional G banding method on the BM. Results Patients’ median age was 62.3 (ranged from 50–76), and the majority were male (72.8%). The most common clinical symptom at the time of admission was fatigue (n = 33) followed by pallor (n = 27). The most common subgroup was MDS-Multi Lineage Dysplasia (MDS-MLD) (n = 38, 36.8%), followed by MDS-Single Lineage Dysplasia (MDS-SLD) (n = 28, 18.4%). A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by del 17p (n = 9) and monosomy 7 (− 7) (n = 7). Twelve patients (11.65%) were transformed to AML. Conclusion Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. Noteworthy, the male: female ratio was slightly higher in Iran than in previous reports from other parts of the world. Our study is the first report of the clinical, hematological, and cytogenetic spectrum of MDS patients in Iran

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An analysis of the demographic profile, clinical manifestations, investigations and outcome of paediatric myelodysplastic syndrome: A single centre, cross-sectional study

International Journal of Cancer Therapy and Oncology ◽

10.14319/ijcto.33.7 ◽

2015 ◽

Vol 3 (3) ◽

pp. 337

Author(s):

Appaji Lingegowda ◽

Lakshmaiah Kuntegowdenahalli

Keyword(s):

Myelodysplastic Syndrome ◽

Clinical Manifestations ◽

Cross Sectional Study ◽

Sectional Study ◽

Single Centre ◽

Cross Sectional ◽

Demographic Profile

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Valores normativos de aptidão funcional em mulheres não ativas na pós-menopausa

Brazilian Journal of Kinanthropometry and Human Performance ◽

10.5007/1980-0037.2016v18n1p32 ◽

2016 ◽

Vol 18 (1) ◽

pp. 32

Author(s):

Lucas Melo Neves ◽

Ana Claudia De Souza Fortaleza ◽

Fabrício Eduardo Rossi ◽

Tiego Aparecido Diniz ◽

Malena Ricci Picolo ◽

...

Keyword(s):

Postmenopausal Women ◽

Cognitive Impairments ◽

Cross Sectional Study ◽

Brazilian Population ◽

Functional Fitness ◽

Sectional Study ◽

Inclusion Criteria ◽

Cross Sectional ◽

Mean Values ◽

Fitness Test

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n1p32 The aim of this study was to propose the normative table for the non active postmenopausal Brazilian population composed of women aged 50-69 years through the AAHPERD functional fitness test battery. This is a cross-sectional study with 170 postmenopausal women (FSH dose> 26.72 mIU / L). The population was divided into two groups: 50-59 years (n = 97) and 60-69 years (n = 73). The inclusion criteria were not having participated of systematic motor intervention in the six months prior to the study period; not presenting motor or cognitive impairments that could impair the performance of evaluation protocols and absence of comorbidities that could prevent or limit evaluations. The group aged 50-59 years showed mean values of 55.6 ± 2.9 years for age, 54.0 ± 21.1 mIU / ml for FSH, 11.3 ± 1.8 seconds for coordination 20.2 ± 4.0 repetitions for strength, 51.9 ± 11.8 cm for flexibility, 23.0 ± 2.4 seconds for speed and 497 ± 39 seconds for aerobic resistance. The group aged 60-69 years showed mean values of 64.2 ± 2.8 years of age, 54.9 ± 16.1 mIU / ml for FSH, 11.5 ± 2.5 seconds for coordination, 20.2 ± 4.3 repetitions for strength, 54.4 ± 10.9 cm for flexibility, 24.5 ± 4.0 seconds for speed and 507 ± 47 seconds for aerobic resistance. The proposal of a normative table was made possible with the data analyzed, which is a new reference regarding functional fitness studies especially in physically inactive postmenopausal women.

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