Prognostic Significance of Red Blood Cell Distribution Width (RDW) and Diverse Hemogram Ratios in Newly Diagnosed Multiple Myeloma (NDMM)

2019 ◽  
Vol 19 (10) ◽  
pp. e178
Author(s):  
Sara Aida Jiménez-Julià ◽  
Albert Pérez Montaña ◽  
Sandra Pérez León ◽  
Bernardo López Andrade ◽  
José María Sánchez Raga ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Prognostic Significance ◽  
Cell Distribution ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Pre-treatment red blood cell distribution width provides prognostic information in multiple myeloma

2018 ◽  
Vol 481 ◽  
pp. 34-41 ◽  
Author(s):  
Di Zhou ◽  
Peipei Xu ◽  
Miaoxin Peng ◽  
Xiaoyan Shao ◽  
Miao Wang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Prognostic Information ◽  
Distribution Width ◽  
Pre Treatment ◽  
Red Blood Cell Distribution

scholarly journals Prognostic significance of red blood cell distribution width in gastrointestinal cancers

Medicine ◽  
2020 ◽  
Vol 99 (16) ◽  
pp. e19588
Author(s):  
Yongping Zhou ◽  
Xiding Li ◽  
Zhihua Lu ◽  
Lei Zhang ◽  
Tu Dai
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Prognostic Significance ◽  
Cell Distribution ◽  
Gastrointestinal Cancers ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Elevated Red Blood Cell Distribution Width as a Simple Prognostic Factor in Patients with Symptomatic Multiple Myeloma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hyewon Lee ◽  
Sun-Young Kong ◽  
Ji Yeon Sohn ◽  
Hyoeun Shim ◽  
Hye Sun Youn ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Prognostic Factor ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Plasma Cells ◽  
Cell Distribution ◽  
Distribution Width ◽  
Poor Prognostic Factor ◽  
Inflammatory Biomarker ◽  
Red Blood Cell Distribution

Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 symptomatic myeloma patients with available RDW at diagnosis were retrospectively reviewed, and their characteristics were compared between two groups, those with high (>14.5%) and normal (≤14.5%) RDW. RDW was correlated to hemoglobin, MM stage,β2-microglobulin, M-protein, bone marrow plasma cells, and cellularity (P<0.001). During induction, overall response rates of the two groups were similar (P=0.195); however, complete response rate was higher in the normal-RDW group than it was in the high-RDW group (P=0.005). With a median follow-up of 47 months, the normal-RDW group showed better progression-free survival (PFS) (24.2 versus 17.0 months,P=0.029) compared to the high-RDW group. Overall survival was not different according to the RDW level (P=0.236). In multivariate analysis, elevated RDW at diagnosis was a poor prognostic factor for PFS (HR 3.21, 95% CI 1.24–8.32) after adjustment with other myeloma-related prognostic factors. RDW would be a simple and immediately available biomarker of symptomatic MM, reflecting the systemic inflammation.

scholarly journals Prognostic significance of red blood cell distribution width in gastrointestinal disorders

2017 ◽  
Vol 23 (27) ◽  
pp. 4879 ◽  
Author(s):  
Hemant Goyal ◽  
Giuseppe Lippi ◽  
Altin Gjymishka ◽  
Bijo John ◽  
Rajiv Chhabra ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Prognostic Significance ◽  
Gastrointestinal Disorders ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Red blood cell distribution width to platelet ratio substantiates preoperative survival prediction in patients with newly-diagnosed glioblastoma

2021 ◽  
Author(s):  
Matthias Schneider ◽  
Niklas Schäfer ◽  
Stefanos Apallas ◽  
Anna-Laura Potthoff ◽  
Christian Bode ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Routine Laboratory ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Laboratory Values ◽  
Newly Diagnosed Glioblastoma ◽  
Red Blood Cell Distribution

Abstract Object The conception of individual patient-adjusted treatment strategies is constantly emerging in the field of neuro-oncology. Systemic laboratory markers may allow insights into individual needs and estimated treatment benefit at an earliest possible stage. Therefore, the present study was aimed at analyzing the prognostic significance of preoperative routine laboratory values in patients with newly-diagnosed glioblastoma. Methods Between 2014 and 2019, 257 patients were surgically treated for newly-diagnosed glioblastoma at the Neuro-Oncology Center of the University Hospital Bonn. Preoperative routine laboratory values including red blood cell distribution width (RDW) and platelet count were reviewed. RDW to platelet count ratio (RPR) was calculated and correlated to overall survival (OS) rates. Results Median preoperative RPR was 0.053 (IQR 0.044–0.062). The receiver operating characteristic (ROC) curve indicated an optimal cut-off value for RPR to be 0.05 (AUC 0.62; p = 0.002, 95% CI 0.544–0.685). 101 patients (39%) presented with a preoperative RPR < 0.05, whereas 156 patients (61%) had a RPR ≥ 0.05. Patients with preoperative RPR < 0.05 exhibited a median OS of 20 months (95% CI 17.9–22.1), which was significantly higher compared to a median OS of 13 months (95% CI 10.9–15.1) in patients with preoperative RPR ≥ 0.05 (p < 0.001). Conclusions The present study suggests the RPR to constitute a novel prognostic inflammatory marker for glioblastoma patients in the course of preoperative routine laboratory examinations and might contribute to a personalized medicine approach.

scholarly journals Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

2018 ◽  
Vol 26 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Daniel Vasile Balaban ◽  
Alina Popp ◽  
Acs Beata ◽  
Florina Vasilescu ◽  
Mariana Jinga
Keyword(s):  
Celiac Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Control Group ◽  
Cell Distribution ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Mean Values ◽  
Diagnostic Strategies ◽  
Red Blood Cell Distribution

Abstract Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last decades to increase its diagnostic rate. This has lead to a high need for developing new diagnostic strategies. Our aim was to evaluate the diagnostic performance of two routine hematologic indices for CD. Methods. In a prospective observational study, 34 newly diagnosed CD patients, 34 age-sex matched controls with irritable bowel syndrome (IBS) and 16 treated CD patients were assessed regarding the differences in mean lymphocyte count (LY), red blood cell distribution width (RDW) and their ratio (RDW/LY). Results. Elevated RDW (>14) and lymphopenia (<1.5 x 10e9/L) were more frequently seen in newly diagnosed CD patients compared to IBS control group and treated CD patients. Newly diagnosed CD patients had significantly higher mean values of RDW/LY - 10.09, compared to 7.72 in the CD-treated group and 6.79 in IBS controls (p<0.01). Subgroup analysis revealed that RDW/LY was higher in patients with destructive histology (Marsh≥3a), 10.54 vs. 7.99. For a value over 7, RDW/LY had a sensitivity of 88.24% (95% CI 72.55-96.70%) and AUROC of 0.785 (95% CI 0.683- 0.887). Conclusions. RDW/LY ratio is a widely available tool which could be used routinely in clinical practice for CD screening.

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