scholarly journals Significance of Pretreatment Red Blood Cell Distribution Width in Patients with Newly Diagnosed Glioblastoma

2017 ◽  
Vol 23 ◽  
pp. 3217-3223 ◽  
Author(s):  
Ruo-fei Liang ◽  
Mao Li ◽  
Yuan Yang ◽  
Qing Mao ◽  
Yan-hui Liu
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Newly Diagnosed Glioblastoma ◽  
Red Blood Cell Distribution

scholarly journals Red blood cell distribution width to platelet ratio substantiates preoperative survival prediction in patients with newly-diagnosed glioblastoma

2021 ◽  
Author(s):  
Matthias Schneider ◽  
Niklas Schäfer ◽  
Stefanos Apallas ◽  
Anna-Laura Potthoff ◽  
Christian Bode ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Routine Laboratory ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Laboratory Values ◽  
Newly Diagnosed Glioblastoma ◽  
Red Blood Cell Distribution

Abstract Object The conception of individual patient-adjusted treatment strategies is constantly emerging in the field of neuro-oncology. Systemic laboratory markers may allow insights into individual needs and estimated treatment benefit at an earliest possible stage. Therefore, the present study was aimed at analyzing the prognostic significance of preoperative routine laboratory values in patients with newly-diagnosed glioblastoma. Methods Between 2014 and 2019, 257 patients were surgically treated for newly-diagnosed glioblastoma at the Neuro-Oncology Center of the University Hospital Bonn. Preoperative routine laboratory values including red blood cell distribution width (RDW) and platelet count were reviewed. RDW to platelet count ratio (RPR) was calculated and correlated to overall survival (OS) rates. Results Median preoperative RPR was 0.053 (IQR 0.044–0.062). The receiver operating characteristic (ROC) curve indicated an optimal cut-off value for RPR to be 0.05 (AUC 0.62; p = 0.002, 95% CI 0.544–0.685). 101 patients (39%) presented with a preoperative RPR < 0.05, whereas 156 patients (61%) had a RPR ≥ 0.05. Patients with preoperative RPR < 0.05 exhibited a median OS of 20 months (95% CI 17.9–22.1), which was significantly higher compared to a median OS of 13 months (95% CI 10.9–15.1) in patients with preoperative RPR ≥ 0.05 (p < 0.001). Conclusions The present study suggests the RPR to constitute a novel prognostic inflammatory marker for glioblastoma patients in the course of preoperative routine laboratory examinations and might contribute to a personalized medicine approach.

scholarly journals Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

2018 ◽  
Vol 26 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Daniel Vasile Balaban ◽  
Alina Popp ◽  
Acs Beata ◽  
Florina Vasilescu ◽  
Mariana Jinga
Keyword(s):  
Celiac Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Control Group ◽  
Cell Distribution ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Mean Values ◽  
Diagnostic Strategies ◽  
Red Blood Cell Distribution

Abstract Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last decades to increase its diagnostic rate. This has lead to a high need for developing new diagnostic strategies. Our aim was to evaluate the diagnostic performance of two routine hematologic indices for CD. Methods. In a prospective observational study, 34 newly diagnosed CD patients, 34 age-sex matched controls with irritable bowel syndrome (IBS) and 16 treated CD patients were assessed regarding the differences in mean lymphocyte count (LY), red blood cell distribution width (RDW) and their ratio (RDW/LY). Results. Elevated RDW (>14) and lymphopenia (<1.5 x 10e9/L) were more frequently seen in newly diagnosed CD patients compared to IBS control group and treated CD patients. Newly diagnosed CD patients had significantly higher mean values of RDW/LY - 10.09, compared to 7.72 in the CD-treated group and 6.79 in IBS controls (p<0.01). Subgroup analysis revealed that RDW/LY was higher in patients with destructive histology (Marsh≥3a), 10.54 vs. 7.99. For a value over 7, RDW/LY had a sensitivity of 88.24% (95% CI 72.55-96.70%) and AUROC of 0.785 (95% CI 0.683- 0.887). Conclusions. RDW/LY ratio is a widely available tool which could be used routinely in clinical practice for CD screening.

Prognostic Significance of Red Blood Cell Distribution Width (RDW) and Diverse Hemogram Ratios in Newly Diagnosed Multiple Myeloma (NDMM)

2019 ◽  
Vol 19 (10) ◽  
pp. e178
Author(s):  
Sara Aida Jiménez-Julià ◽  
Albert Pérez Montaña ◽  
Sandra Pérez León ◽  
Bernardo López Andrade ◽  
José María Sánchez Raga ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Prognostic Significance ◽  
Cell Distribution ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Red Blood Cell Distribution Width, Disease Severity, and Mortality in Hospitalized Patients with SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (2) ◽  
pp. 286
Author(s):  
Angelo Zinellu ◽  
Arduino A. Mangoni
Keyword(s):  
Systematic Review ◽  
Blood Cell ◽  
Disease Severity ◽  
Red Blood Cell ◽  
Effect Size ◽  
Meta Analysis ◽  
Severe Illness ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The identification of biomarkers predicting disease severity and outcomes is the focus of intense research in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Ideally, such biomarkers should be easily derivable from routine tests. We conducted a systematic review and meta-analysis of the predictive role of the red blood cell distribution width (RDW), a routine hematological test, in patients with SARS-CoV-2 infection. We searched the electronic databases PubMed, Web of Science and Scopus, from January 2020 to November 2020, for studies reporting data on the RDW and coronavirus disease 2019 (COVID-19) severity, defined as severe illness or admission to the intensive care unit (ICU), and mortality. Eleven studies in 4901 COVID-19 patients were selected for the meta-analysis. Pooled results showed that the RDW values were significantly higher in patients with severe disease and non-survivors (standard mean difference, SMD = 0.56, 95% CI 0.31 to 0.81, p < 0.001). Heterogeneity between studies was extreme (I2 = 80.6%; p < 0.001). In sensitivity analysis, the effect size was not modified when each study was in turn removed (effect size range, between 0.47 and 0.63). The Begg’s (p = 0.53) and Egger’s tests (p = 0.52) showed no evidence of publication bias. No significant correlations were observed between SMD and age, gender, whole blood count, end point, study geographic area, or design. Our meta-analysis showed that higher RDW values are significantly associated with COVID-19 severity and mortality. This routine parameter might assist with early risk stratification in patients with SARS-CoV-2 infection.

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