scholarly journals Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

2018 ◽  
Vol 26 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Daniel Vasile Balaban ◽  
Alina Popp ◽  
Acs Beata ◽  
Florina Vasilescu ◽  
Mariana Jinga
Keyword(s):  
Celiac Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Control Group ◽  
Cell Distribution ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Mean Values ◽  
Diagnostic Strategies ◽  
Red Blood Cell Distribution

Abstract Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last decades to increase its diagnostic rate. This has lead to a high need for developing new diagnostic strategies. Our aim was to evaluate the diagnostic performance of two routine hematologic indices for CD. Methods. In a prospective observational study, 34 newly diagnosed CD patients, 34 age-sex matched controls with irritable bowel syndrome (IBS) and 16 treated CD patients were assessed regarding the differences in mean lymphocyte count (LY), red blood cell distribution width (RDW) and their ratio (RDW/LY). Results. Elevated RDW (>14) and lymphopenia (<1.5 x 10e9/L) were more frequently seen in newly diagnosed CD patients compared to IBS control group and treated CD patients. Newly diagnosed CD patients had significantly higher mean values of RDW/LY - 10.09, compared to 7.72 in the CD-treated group and 6.79 in IBS controls (p<0.01). Subgroup analysis revealed that RDW/LY was higher in patients with destructive histology (Marsh≥3a), 10.54 vs. 7.99. For a value over 7, RDW/LY had a sensitivity of 88.24% (95% CI 72.55-96.70%) and AUROC of 0.785 (95% CI 0.683- 0.887). Conclusions. RDW/LY ratio is a widely available tool which could be used routinely in clinical practice for CD screening.

scholarly journals Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yingbo Ma ◽  
Shengjie Li ◽  
Aiping Zhang ◽  
Yi Ma ◽  
Yani Wan ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Cell Distribution ◽  
Distribution Width ◽  
Control Study ◽  
Red Blood Cell Distribution

Purpose. Red blood cell distribution width (RDW) has been regarded as an emerging biomarker of the general population and cardiovascular disease. In this study, we aimed to evaluate the association between RDW and diabetic retinopathy (DR). Methods. This case-control study included 167 patients with DR, 131 patients with diabetes mellitus (DM), and 170 age- and sex-matched healthy controls from April 2014 to May 2019. Demographic data, laboratory parameters, and ocular examinations were collected. Results. RDW values of the DR group were significantly higher than those of the healthy control ( p < 0.001 ) and DM group ( p = 0.002 ). A similar trend was observed when RDW was compared among the 3 groups with respect to age and gender. Logistic regression analysis has shown the OR of RDW was 3.791 (2.33–6.168; p < 0.001 ) against the control group and was 1.348 (0.997–1.823; p = 0.047 ) against the DM group. Conclusion. RDW values were significantly elevated in DR patients, and an elevated RDW was associated with an increased incidence of DR in patients with DM.

scholarly journals The value of hemoglobin-to-red blood cell distribution width ratio (Hb/RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the diagnosis of nasopharyngeal cancer

2020 ◽  
Author(s):  
Zhongyuan Lin Lin ◽  
Xuan Zhang ◽  
Songshan Zhu ◽  
Yu Luo ◽  
Yanyun Chen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Nasopharyngeal Cancer ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Cell Distribution ◽  
Platelet To Lymphocyte Ratio ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Red Blood Cell Distribution

Abstract Background: The clinical significance of hemoglobin-to-red blood cell distribution width (Hb/RDW) for the diagnosis of nasopharyngeal cancer (NPC) has not been reported yet. This study aimed to evaluate the value of preoperative Hb/RDW, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the diagnosis of NPC.Methods: A total of 180 NPC patients (NPC group) and 149 healthy subjects (control group) were recruited to assess the value of Hb/RDW, NLR, and PLR for the diagnosis of NPC. Results: It was noted that NLR and PLR were significantly higher in the NPC group than those in the control group (P<0.001), however, Hb/RDW was lower in the NPC group compared with that in the control group (P<0.001). NLR was also remarkably different between patients of stageⅠ+Ⅱ and those of stage Ⅲ+Ⅳ (P=0.043), and that was different in patients with lymph node metastases or not(P=0.030). Besides, PLR was significantly different in patients with serosal invasion or not (P=0.031).Compared with Hb/RDW alone (sensitivity, 66.67%; specificity, 85.23%), the sensitivity (67.78%, 72.78%) and specificity (89.62%, 90.6%) of Hb/RDW with NLR and PLR were both increased. Furthermore, Hb/RDW combined with NLR (area under the receiver operating characteristic curve (ROC) (AUC), 0.824; 95% confidence interval (CI):0.779-0.864, P=0.0080) or PLR (AUC:0.851, 95%CI:0.808-0.888, P=0.0002) had a greater AUC value for the diagnosis of NPC compared with Hb/RDW alone (AUC: 0.781, 95% CI: 0.732-0.824).Conclusion: Hb/RDW can be used as a valuable indicator for the diagnosis of NPC. Preoperative Hb/RDW combined with NLR or PLR had higher value for the diagnosis of NPC.

scholarly journals Red blood cell distribution width to platelet ratio substantiates preoperative survival prediction in patients with newly-diagnosed glioblastoma

2021 ◽  
Author(s):  
Matthias Schneider ◽  
Niklas Schäfer ◽  
Stefanos Apallas ◽  
Anna-Laura Potthoff ◽  
Christian Bode ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Routine Laboratory ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Laboratory Values ◽  
Newly Diagnosed Glioblastoma ◽  
Red Blood Cell Distribution

Abstract Object The conception of individual patient-adjusted treatment strategies is constantly emerging in the field of neuro-oncology. Systemic laboratory markers may allow insights into individual needs and estimated treatment benefit at an earliest possible stage. Therefore, the present study was aimed at analyzing the prognostic significance of preoperative routine laboratory values in patients with newly-diagnosed glioblastoma. Methods Between 2014 and 2019, 257 patients were surgically treated for newly-diagnosed glioblastoma at the Neuro-Oncology Center of the University Hospital Bonn. Preoperative routine laboratory values including red blood cell distribution width (RDW) and platelet count were reviewed. RDW to platelet count ratio (RPR) was calculated and correlated to overall survival (OS) rates. Results Median preoperative RPR was 0.053 (IQR 0.044–0.062). The receiver operating characteristic (ROC) curve indicated an optimal cut-off value for RPR to be 0.05 (AUC 0.62; p = 0.002, 95% CI 0.544–0.685). 101 patients (39%) presented with a preoperative RPR < 0.05, whereas 156 patients (61%) had a RPR ≥ 0.05. Patients with preoperative RPR < 0.05 exhibited a median OS of 20 months (95% CI 17.9–22.1), which was significantly higher compared to a median OS of 13 months (95% CI 10.9–15.1) in patients with preoperative RPR ≥ 0.05 (p < 0.001). Conclusions The present study suggests the RPR to constitute a novel prognostic inflammatory marker for glioblastoma patients in the course of preoperative routine laboratory examinations and might contribute to a personalized medicine approach.

scholarly journals Significance of red blood cell distribution width in children with celiac disease

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Orlando Cortes ◽  
Tebyan Rabbani ◽  
Ronald Thomas ◽  
Kristen Cares
Keyword(s):  
Celiac Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Red blood cell distribution width as a predictor of long term outcome of celiac disease

2017 ◽  
Vol 49 (4) ◽  
pp. e272
Author(s):  
G. Paiola ◽  
G. Tezza ◽  
G. Turcato ◽  
M. Deganello Saccomani ◽  
C. Banzato
Keyword(s):  
Celiac Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Term Outcome ◽  
Distribution Width ◽  
Long Term Outcome ◽  
Red Blood Cell Distribution

scholarly journals Analysis of the Effect of Intelligent Red Blood Cell Distribution Diagnosis Model on the Diagnosis and Treatment of Gastrointestinal Bleeding

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xibin Sun ◽  
Yuhong Zhang ◽  
Jiaxin Li ◽  
Bin Zhang ◽  
Qian Jia
Keyword(s):  
Blood Cell ◽  
Gastrointestinal Bleeding ◽  
Red Blood Cell ◽  
Diagnosis And Treatment ◽  
Control Group ◽  
Cell Distribution ◽  
Distribution Width ◽  
Diagnosis And Management ◽  
Diagnosis Model ◽  
Red Blood Cell Distribution

In order to explore the role of red blood cell distribution width in the diagnosis and treatment of gastrointestinal bleeding, this paper applies map feature recognition technology to red blood cell distribution broadband and constructs an intelligent red blood cell distribution width diagnosis model. To extract the content-level features of the image safely and effectively, this paper introduces the mechanism of jitter quantization to extract the content-level features at the lowest frequency of the image. In addition, this article employs an experimental approach to investigate the function of red blood cell distribution width in the diagnosis and management of gastrointestinal bleeding in the elderly. Finally, this article establishes an experimental group and a control group and then performs a research study using real-life hospital case studies. According to the statistical findings, the red blood cell distribution width index may play a significant role in the diagnosis and management of gastrointestinal bleeding, particularly in the case of severe bleeding.

Prognostic Significance of Red Blood Cell Distribution Width (RDW) and Diverse Hemogram Ratios in Newly Diagnosed Multiple Myeloma (NDMM)

2019 ◽  
Vol 19 (10) ◽  
pp. e178
Author(s):  
Sara Aida Jiménez-Julià ◽  
Albert Pérez Montaña ◽  
Sandra Pérez León ◽  
Bernardo López Andrade ◽  
José María Sánchez Raga ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Prognostic Significance ◽  
Cell Distribution ◽  
Newly Diagnosed ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnancy women

2021 ◽  
Vol 16 (1) ◽  
pp. 1213-1218
Author(s):  
Yang Kai ◽  
Pan Ying ◽  
Yan Bo ◽  
Yu Furong ◽  
Chen Jin ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Roc Curves ◽  
Deficiency Anemia ◽  
Control Group ◽  
Cell Distribution ◽  
Distribution Width ◽  
Width Coefficient ◽  
Red Blood Cell Distribution

Abstract The aim of this study was to compare the diagnostic values of red blood cell distribution width-coefficient of variation (RDW-CV) and red blood cell distribution width-standard deviation (RDW-SD) in mid-pregnancy women with iron deficiency anemia (IDA). To obtain the results, 115 mid-pregnancy women with IDA, defined as the IDA group, and 142 healthy mid-pregnancy women, selected as the control group, were enrolled in this study. Hematological parameters and ferritin concentrations in the serum were analyzed. The efficiency of RDW-CV and RDW-SD to distinguish IDA from mid-pregnancy women was evaluated using receiver operating characteristic (ROC) curves. The RDW-SD value in the IDA group was significantly higher than that in the control group (p < 0.05), while the RDW-CV value did not differ between them (p = 0.84). Significantly negative correlations were found between RDW-CV (r = −0.297, p = 0.001), RDW-SD (r = −0.404, p = 0.000), and serum ferritin in the IDA group but not in the control group. For the diagnosis of IDA, RDW-CV and RDW-SD produced areas under the ROC curves of 0.58 and 0.84. To conclude, our results suggest that RDW-SD, but not RDW-CV, can be used as a diagnostic index of IDA for mid-pregnancy women.

scholarly journals Associations of lymphocyte percentage and red blood cell distribution width with risk of lung cancer

2019 ◽  
Vol 47 (7) ◽  
pp. 3099-3108 ◽  
Author(s):  
Cong Ma ◽  
Xiaoyan Wang ◽  
Rui Zhao
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Lung Cancer Risk ◽  
Control Group ◽  
Cell Distribution ◽  
Distribution Width ◽  
Ample Evidence ◽  
Red Blood Cell Distribution

Objective There is ample evidence to indicate that inflammation is involved in tumorigenesis. Lymphocyte percentage (LYM%) and red blood cell distribution width (RDW) are easily measured indicators of systemic inflammation. This study aimed to investigate the associations between LYM% and RDW and the risk of lung cancer. Methods We retrospectively reviewed the records of 430 patients with lung cancer and 158 healthy individuals (control group). Twenty clinical characteristics were analyzed, including LYM% and RDW. Significant laboratory indices were determined by univariate analysis and logistic regression was conducted to identify independent predictors of lung cancer risk. Results Patients with lung cancer had significantly lower LYM% and higher RDW levels compared with healthy controls. LYM% and RDW were confirmed to be independent predictors of lung cancer risk. LYM% also differed significantly among different histological subtypes of lung cancer. Conclusion A high risk of lung cancer was closely correlated with low LYM% and high RDW. LYM% and RDW are easily measured and may therefore aid the assessment and timely screening of lung cancer risk.

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