Moderate alcohol consumption and lipoprotein subfractions: a systematic review of intervention and observational studies

2021 ◽  
Vol 46 ◽  
pp. S631-S632
Author(s):  
T.L. Wilkens ◽  
K. Tranæs ◽  
J.N. Eriksen ◽  
L.O. Dragsted
Keyword(s):  
Systematic Review ◽  
Alcohol Consumption ◽  
Observational Studies ◽  
Moderate Alcohol Consumption ◽  
Lipoprotein Subfractions

Abstract P149: The Effect of Alcohol Consumption on Insulin Sensitivity and Glycemic Status: A Systematic Review and Meta-analysis of Intervention Studies

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Ilse C Schrieks ◽  
Annelijn L Heil ◽  
Henk F Hendriks ◽  
Kenneth J Mukamal ◽  
Joline W Beulens
Keyword(s):  
Systematic Review ◽  
Insulin Sensitivity ◽  
Alcohol Consumption ◽  
Intervention Studies ◽  
Meta Analysis ◽  
Moderate Alcohol Consumption ◽  
Fasting Insulin ◽  
Glycemic Status ◽  
Reduced Risk

Introduction: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes, but this relation appears stronger for women than men. The reduced risk of diabetes could be explained by improved insulin sensitivity or glycemic status, but results of intervention studies on this relation are inconsistent. Our aim was to conduct a systematic review and meta-analysis of intervention studies investigating the effect of alcohol consumption on insulin sensitivity and glycemic status. Design: Systematic review and meta-analysis of intervention studies. Data sources: PubMed and Embase were searched until May 2013 using a pre-specified search string. Methods: Intervention studies on the effect of more than 2 weeks alcohol consumption on biological markers of insulin sensitivity or glycemic status were identified and assessed on their quality. Pooled standardized mean differences (SMD) were calculated using either fixed or random effects models. Gender-stratified analyses and sensitivity analyses excluding studies with high doses of alcohol (> 40 g/day). In a meta-regression the influence of dosage and duration of intervention was tested. Results: We included 14 intervention studies in a meta-analysis on 6 glycemic endpoints. Alcohol consumption did not influence insulin sensitivity (SMD=0.06 [-0.13 to 0.26]) or fasting glucose (SMD=0.09 [-0.09 to 0.27]). Alcohol consumption reduced HbA1c (SMD=-0.62 [-1.01 to -0.23], P=0.002) and insulin concentrations (SMD=-0.17 [-0.34 to 0.00] P=0.049) compared with the control group. In women, alcohol consumption reduced fasting insulin (SMD=-0.23 [-0.41 to -0.04], P=0.019) and improved insulin sensitivity (SMD=0.19 [-0.03 to 0.41], P=0.087), but no significant differences were observed among men. Results were similar when only studies with moderate alcohol dosages were analysed and were not influenced by dosage and duration of the intervention. Conclusions: This study showed that moderate alcohol consumption may reduce fasting insulin and improve insulin sensitivity among women, but not among men. These effects may provide an explanation for the relation between alcohol consumption and type 2 diabetes. Furthermore, moderate alcohol consumption may reduce HbA1c levels among both men and women.

scholarly journals The Effect of Alcohol Consumption on Insulin Sensitivity and Glycemic Status: A Systematic Review and Meta-analysis of Intervention Studies

Diabetes Care ◽  
2015 ◽  
Vol 38 (4) ◽  
pp. 723-732
Author(s):  
Ilse C. Schrieks ◽  
Annelijn L.J. Heil ◽  
Henk F.J. Hendriks ◽  
Kenneth J. Mukamal ◽  
Joline W.J. Beulens
Keyword(s):  
Systematic Review ◽  
Insulin Sensitivity ◽  
Alcohol Consumption ◽  
Intervention Studies ◽  
Meta Analysis ◽  
Moderate Alcohol Consumption ◽  
Fasting Insulin ◽  
Improve Insulin Sensitivity ◽  
Glycemic Status ◽  
Reduced Risk

OBJECTIVE Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of intervention studies investigating the effect of alcohol consumption on insulin sensitivity and glycemic status. RESEARCH DESIGN AND METHODS PubMed and Embase were searched up to August 2014. Intervention studies on the effect of alcohol consumption on biological markers of insulin sensitivity or glycemic status of at least 2 weeks' duration were included. Investigators extracted data on study characteristics, outcome measures, and methodological quality. RESULTS Fourteen intervention studies were included in a meta-analysis of six glycemic end points. Alcohol consumption did not influence estimated insulin sensitivity (standardized mean difference [SMD] 0.08 [−0.09 to 0.24]) or fasting glucose (SMD 0.07 [−0.11 to 0.24]) but reduced HbA1c (SMD −0.62 [−1.01 to −0.23]) and fasting insulin concentrations (SMD −0.19 [−0.35 to −0.02]) compared with the control condition. Alcohol consumption among women reduced fasting insulin (SMD −0.23 [−0.41 to −0.04]) and tended to improve insulin sensitivity (SMD 0.16 [−0.04 to 0.37]) but not among men. Results were similar after excluding studies with high alcohol dosages (>40 g/day) and were not influenced by dosage and duration of the intervention. CONCLUSIONS Although the studies had small sample sizes and were of short duration, the current evidence suggests that moderate alcohol consumption may decrease fasting insulin and HbA1c concentrations among nondiabetic subjects. Alcohol consumption might improve insulin sensitivity among women but did not do so overall.

The prevalence of and factors related to alcohol consumption among young people in Thailand: a systematic review of observational studies

2020 ◽  
Vol 27 (5) ◽  
pp. 337-358
Author(s):  
Trakulwong Luecha ◽  
Lieve Peremans ◽  
Tinne Dilles ◽  
Patcharin Poontawee ◽  
Bart Van Rompaey
Keyword(s):  
Systematic Review ◽  
Alcohol Consumption ◽  
Young People ◽  
Observational Studies

scholarly journals Are there non-linear relationships between alcohol consumption and long-term health? Protocol for a systematic review of observational studies employing approaches to improve causal inference

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e043985
Author(s):  
Rachel Visontay ◽  
Matthew Sunderland ◽  
Tim Slade ◽  
Jack Wilson ◽  
Louise Mewton
Keyword(s):  
Systematic Review ◽  
Alcohol Consumption ◽  
Health Outcomes ◽  
Causal Inference ◽  
Study Design ◽  
Observational Studies ◽  
Alcohol Exposure ◽  
Non Linear ◽  
The Relationship

IntroductionThere is a substantial literature finding that moderate alcohol consumption is protective against certain health conditions. However, more recent research has highlighted the possibility that these findings are methodological artefacts, caused by confounding and other biases. While modern analytical and study design approaches can mitigate confounding and thus enhance causal inference in observational studies, they are not routinely applied in research assessing the relationship between alcohol use and long-term health outcomes. The purpose of this systematic review is to identify observational studies that employ these analytical/design-based approaches in assessing whether relationships between alcohol consumption and health outcomes are non-linear. This review seeks to evaluate, on a per-outcome basis, what these studies find the strength and form of the relationship between alcohol consumption and health to be.Methods and analysisElectronic databases (MEDLINE, PsycINFO, Embase and SCOPUS) were searched in May 2020. Study selection will comply with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Articles will be screened against eligibility criteria intended to capture studies using observational data to assess the relationship between varying levels of alcohol exposure and any long-term health outcome (actual or surrogate), and that have employed at least one of the prespecified approaches to enhancing causal inference. Risk of bias of included articles will be assessed using study design-specific tools. A narrative synthesis of the results is planned.Ethics and disseminationFormal ethics approval is not required given there will be no primary data collection. The results of the study will be disseminated through published manuscripts, conferences and seminar presentations.PROSPERO registration numberCRD42020185861.

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