Is Moderate Alcohol Consumption a Risk Factor for Kidney Function Decline? A Systematic Review of Observational Studies

Introduction: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes, but this relation appears stronger for women than men. The reduced risk of diabetes could be explained by improved insulin sensitivity or glycemic status, but results of intervention studies on this relation are inconsistent. Our aim was to conduct a systematic review and meta-analysis of intervention studies investigating the effect of alcohol consumption on insulin sensitivity and glycemic status. Design: Systematic review and meta-analysis of intervention studies. Data sources: PubMed and Embase were searched until May 2013 using a pre-specified search string. Methods: Intervention studies on the effect of more than 2 weeks alcohol consumption on biological markers of insulin sensitivity or glycemic status were identified and assessed on their quality. Pooled standardized mean differences (SMD) were calculated using either fixed or random effects models. Gender-stratified analyses and sensitivity analyses excluding studies with high doses of alcohol (> 40 g/day). In a meta-regression the influence of dosage and duration of intervention was tested. Results: We included 14 intervention studies in a meta-analysis on 6 glycemic endpoints. Alcohol consumption did not influence insulin sensitivity (SMD=0.06 [-0.13 to 0.26]) or fasting glucose (SMD=0.09 [-0.09 to 0.27]). Alcohol consumption reduced HbA1c (SMD=-0.62 [-1.01 to -0.23], P=0.002) and insulin concentrations (SMD=-0.17 [-0.34 to 0.00] P=0.049) compared with the control group. In women, alcohol consumption reduced fasting insulin (SMD=-0.23 [-0.41 to -0.04], P=0.019) and improved insulin sensitivity (SMD=0.19 [-0.03 to 0.41], P=0.087), but no significant differences were observed among men. Results were similar when only studies with moderate alcohol dosages were analysed and were not influenced by dosage and duration of the intervention. Conclusions: This study showed that moderate alcohol consumption may reduce fasting insulin and improve insulin sensitivity among women, but not among men. These effects may provide an explanation for the relation between alcohol consumption and type 2 diabetes. Furthermore, moderate alcohol consumption may reduce HbA1c levels among both men and women.

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OWE-33 Can moderate alcohol consumption decrease pancreatic ductal adenocarcinoma (PDAC) risk? a systematic review and meta-analysis

10.1136/gutjnl-2019-bsgabstracts.293 ◽

2019 ◽

Author(s):

Thomas Payne ◽

Stephen Lam ◽

Andrew Hart

Keyword(s):

Systematic Review ◽

Alcohol Consumption ◽

Pancreatic Ductal Adenocarcinoma ◽

Meta Analysis ◽

Ductal Adenocarcinoma ◽

Moderate Alcohol Consumption

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Intermediate CAG Repeat Expansion in the ATXN2 Gene Is a Unique Genetic Risk Factor for ALS−A Systematic Review and Meta-Analysis of Observational Studies

PLoS ONE ◽

10.1371/journal.pone.0105534 ◽

2014 ◽

Vol 9 (8) ◽

pp. e105534 ◽

Cited By ~ 18

Author(s):

Ming-Dong Wang ◽

James Gomes ◽

Neil R. Cashman ◽

Julian Little ◽

Daniel Krewski

Keyword(s):

Systematic Review ◽

Risk Factor ◽

Genetic Risk ◽

Observational Studies ◽

Meta Analysis ◽

Repeat Expansion ◽

Genetic Risk Factor ◽

Cag Repeat ◽

Cag Repeat Expansion

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The Effect of Alcohol Consumption on Insulin Sensitivity and Glycemic Status: A Systematic Review and Meta-analysis of Intervention Studies

Diabetes Care ◽

10.2337/dc14-1556 ◽

2015 ◽

Vol 38 (4) ◽

pp. 723-732

Author(s):

Ilse C. Schrieks ◽

Annelijn L.J. Heil ◽

Henk F.J. Hendriks ◽

Kenneth J. Mukamal ◽

Joline W.J. Beulens

Keyword(s):

Systematic Review ◽

Insulin Sensitivity ◽

Alcohol Consumption ◽

Intervention Studies ◽

Meta Analysis ◽

Moderate Alcohol Consumption ◽

Fasting Insulin ◽

Improve Insulin Sensitivity ◽

Glycemic Status ◽

Reduced Risk

OBJECTIVE Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of intervention studies investigating the effect of alcohol consumption on insulin sensitivity and glycemic status. RESEARCH DESIGN AND METHODS PubMed and Embase were searched up to August 2014. Intervention studies on the effect of alcohol consumption on biological markers of insulin sensitivity or glycemic status of at least 2 weeks' duration were included. Investigators extracted data on study characteristics, outcome measures, and methodological quality. RESULTS Fourteen intervention studies were included in a meta-analysis of six glycemic end points. Alcohol consumption did not influence estimated insulin sensitivity (standardized mean difference [SMD] 0.08 [−0.09 to 0.24]) or fasting glucose (SMD 0.07 [−0.11 to 0.24]) but reduced HbA1c (SMD −0.62 [−1.01 to −0.23]) and fasting insulin concentrations (SMD −0.19 [−0.35 to −0.02]) compared with the control condition. Alcohol consumption among women reduced fasting insulin (SMD −0.23 [−0.41 to −0.04]) and tended to improve insulin sensitivity (SMD 0.16 [−0.04 to 0.37]) but not among men. Results were similar after excluding studies with high alcohol dosages (>40 g/day) and were not influenced by dosage and duration of the intervention. CONCLUSIONS Although the studies had small sample sizes and were of short duration, the current evidence suggests that moderate alcohol consumption may decrease fasting insulin and HbA1c concentrations among nondiabetic subjects. Alcohol consumption might improve insulin sensitivity among women but did not do so overall.

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Impact of mild-to-moderate alcohol consumption and smoking on kidney function

Hypertension Research ◽

10.1038/hr.2017.51 ◽

2017 ◽

Vol 40 (9) ◽

pp. 809-810 ◽

Cited By ~ 1

Author(s):

Naoki Nakagawa ◽

Naoyuki Hasebe

Keyword(s):

Alcohol Consumption ◽

Kidney Function ◽

Moderate Alcohol Consumption

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The association between renal stones and fasting: A systematic review

Canadian Urological Association Journal ◽

10.5489/cuaj.6664 ◽

2020 ◽

Vol 15 (3) ◽

Author(s):

Abirami Kirubarajan ◽

Andrew C.L. Lam ◽

Shawn Khan ◽

Matthew Yau ◽

Nicole Golda ◽

...

Keyword(s):

Systematic Review ◽

Risk Factor ◽

Clinical Outcomes ◽

Observational Studies ◽

Renal Colic ◽

Renal Stones ◽

Cultural Practice ◽

Urine Metabolites ◽

Systematic Assessment ◽

Risk Patients

Introduction: Fasting is a common cultural practice worldwide for both religious and dietary reasons. However, there is concern that fasting may be a risk factor for the development of renal stones. To date, there has not been a systematic assessment of the literature regarding the association between renal stones and fasting. Methods: We conducted a systematic review following PRISMA guidelines of three databases: Medline-OVID, EMBASE, and CINAHL. All screening and extraction was completed in parallel with two independent reviewers. Results: Of the 1501 database citations, a total of 10 observational studies with a total of 9906 participants were included. Nine of the studies were conducted in the context of Islamic fasting during Ramadan, with the majority (7/9) finding that renal colic incidence was unaffected by the month of fasting. In contrast, two studies noted an increased incidence among fasting populations. Two other studies noted that urine metabolites and density were altered with fasting but did not translate into clinical outcomes. Conclusions: Based on the available evidence, it is unlikely that fasting significantly increases the risk of renal stones. Physicians should counsel higher-risk patients on safe fasting practices.

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