A body shape index could serve to identify individuals with metabolic syndrome and increased arterial stiffness in the middle-aged population

Author(s):  
Tomonori Sugiura ◽  
Yasuaki Dohi ◽  
Yasuyuki Takagi ◽  
Takashi Yokochi ◽  
Naofumi Yoshikane ◽  
...  
2019 ◽  
Vol 48 (1) ◽  
pp. 030006051984885 ◽  
Author(s):  
Andrei Stefanescu ◽  
Luis Revilla ◽  
Tania Lopez ◽  
Sixto E. Sanchez ◽  
Michelle A. Williams ◽  
...  

2021 ◽  
Author(s):  
Daiji Nagayama ◽  
Kentaro Fujishiro ◽  
Shinichi Tsuda ◽  
Yasuhiro Watanabe ◽  
Takashi Yamaguchi ◽  
...  

Abstract Background: Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is conventionally evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity. We aimed to examine whether replacing WC with “A Body Shape Index (ABSI)”, an abdominal obesity index, in MetS diagnosis is useful for predicting renal function decline (RFD). Methods: A retrospective cohort study was conducted in 5438 Japanese urban residents (median age 48 years) who participated in a public health screening program for 4 consecutive years. Systemic arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and high CAVI was defined as CAVI ≥ 9.0. The predictability of the occurrence of RFD (eGFR < 60 mL/min/1.73m 2 ) by replacing high WC with high ABSI (ABSI ≥ 0.080) was examined using three sets of MetS diagnostic criteria: Japanese, International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). Results: In Japanese and NCEP-ATPIII criteria, MetS diagnosed using ABSI (ABSI-MetS) was associated with significantly higher age-adjusted CAVI compared to non-MetS, whereas MetS diagnosed using WC (WC-MetS) showed no association. Kaplan-Meier analysis of the rate of new-onset RFD over 4 years (total 8.7%) showed remarkable higher rate in subjects with ABSIMetS than in those without (log-rank test p <0.001), but almost no difference between subjects with and without WC-MetS ( p = 0.014-0.617). In Cox analysis including gender, high CAVI and low-density lipoprotein‒cholesterol ≥140 mg/dL as confounders, only ABSI-MetS diagnosed by Japanese criteria contributed independently to the occurrence of RFD (HR = 1.41, p = 0.011). High CAVI was also an independent contributor to the occurrence of RFD. In a subanalysis, ABSI-MetS diagnosed by Japanese criteria contributed significantly to the occurrence of RFD regardless of age or gender, while WC-MetS by Japanese criteria contributed significantly only in older women. Conclusion: In this study, replacing WC with ABSI in MetS diagnostic criteria more efficiently predicted subjects at risk of RFD and arterial stiffening. Further studies are needed to confirm whether MetS diagnosed using ABSI also predicts CVD.


2016 ◽  
Vol 4 (1) ◽  
pp. e000188 ◽  
Author(s):  
Ryotaro Bouchi ◽  
Masahiro Asakawa ◽  
Norihiko Ohara ◽  
Yujiro Nakano ◽  
Takato Takeuchi ◽  
...  

2017 ◽  
Vol 36 (5) ◽  
pp. 1355-1359 ◽  
Author(s):  
Sen He ◽  
Yi Zheng ◽  
Hua Wang ◽  
Xiaoping Chen

Author(s):  
Daiji Nagayama ◽  
Kentaro Fujishiro ◽  
Shinichi Tsuda ◽  
Yasuhiro Watanabe ◽  
Takashi Yamaguchi ◽  
...  

Abstract Background Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is conventionally evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity. Objective To examine whether replacing WC with “A Body Shape Index (ABSI)”, an abdominal obesity index calculated by dividing WC by an allometric regression of weight and height, in MetS diagnosis is useful for predicting renal function decline. Subjects/Methods In total, 5438 Japanese urban residents (median age 48 years) who participated in a public health screening program for 4 consecutive years were enrolled. Systemic arterial stiffness was assessed by cardio-ankle vascular index (CAVI). The predictability of the new-onset renal function decline (eGFR < 60 mL/min/1.73 m2) by replacing high WC with high ABSI (ABSI ≥ 0.080) was examined using three sets of MetS diagnostic criteria: Japanese, IDF and NCEP-ATPIII. Results In Japanese and NCEP-ATPIII criteria, MetS diagnosed using ABSI (ABSI-MetS) was associated with significantly higher age-adjusted CAVI compared to non-MetS, whereas MetS diagnosed using WC (WC-MetS) showed no association. Kaplan–Meier analysis of the rate of new-onset renal function decline over 4 years (total 8.7%) showed remarkable higher rate in subjects with ABSI-MetS than in those without (log-rank test p < 0.001), but almost no difference between subjects with and without WC-MetS (p = 0.014–0.617). In gender-specific Cox-proportional hazards analyses including age, proteinuria, and treatments of metabolic disorders as confounders, ABSI-MetS (Japanese criteria for both sexes, IDF criteria for men) contributed independently to the new-onset renal function decline. Of these, the contribution of IDF ABSI-MetS disappeared after adjustment by high CAVI in the subsequent analysis. Conclusion In this study, replacing WC with ABSI in MetS diagnostic criteria more efficiently predicted subjects at risk of renal function decline and arterial stiffening.


Obesity Facts ◽  
2022 ◽  
pp. 1-10
Author(s):  
Daiji Nagayama ◽  
Yasuhiro Watanabe ◽  
Takashi Yamaguchi ◽  
Kenji Suzuki ◽  
Atsuhito Saiki ◽  
...  

<b><i>Introduction:</i></b> Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity. This cross-sectional study aimed to clarify whether replacing WC with “A Body Shape Index (ABSI),” an abdominal obesity index, in MetS diagnosis detects individuals with arterial stiffening assessed by cardio-ankle vascular index (CAVI). <b><i>Methods:</i></b> A retrospective cross-sectional study was conducted in 46,872 Japanese urban residents (median age 40 years) who underwent health screening. Exclusion criteria were current treatments and a past history of cardiovascular disease (CVD). The Japanese, International Diabetes Federation, and NCEP-ATPIII criteria were used to diagnose MetS. High CAVI was defined as CAVI ≥9.0. <b><i>Results:</i></b> CAVI correlated positively with ABSI (β = 0.127), but negatively with WC (β = −0.186), independent of age, sex, systolic blood pressure, fasting plasma glucose, and high-density lipoprotein--cholesterol. Receiver operating characteristic (ROC) analysis showed that ABSI had a stronger contribution to high CAVI (area under the ROC curve [AUC] = 0.730) than WC (AUC = 0.595) and body mass index (AUC = 0.520). ABSI ≥0.080 was defined as abdominal obesity based on the results of ROC analysis for high CAVI and estimated glomerular filtration rate &#x3c;60 mL/min/1.73 m<sup>2</sup>. Logistic regression analysis revealed that replacing high WC with ABSI ≥0.080 in MetS diagnosis enhanced the detection of subjects with high CAVI. <b><i>Discussion/Conclusion:</i></b> Use of ABSI can detect subjects with arterial stiffening, which may lead to efficient stratification of CVD risk. Further studies are needed to confirm whether MetS diagnosis using ABSI predicts CVD morbidity and mortality.


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