Numerical simulation of magnetic drug targeting to a tumor in the simplified model of the human lung

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

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Numerical Simulation and Analysis on the Impact Effect of Cylindrical Projectile Impacting Shelled Explosive

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.710.320 ◽

2013 ◽

Vol 710 ◽

pp. 320-324

Author(s):

Ying Zi Jiang ◽

Wei Li Wang ◽

Xue Feng Huang ◽

Lei Fu ◽

Zhuang Qing Fan

Keyword(s):

Numerical Simulation ◽

Energy Criterion ◽

Critical Energy ◽

Simplified Model ◽

Initiation Point ◽

4340 Steel ◽

Simulation Results ◽

The Impact ◽

Explosive Detonation ◽

Critical Initiation

The numerical simulation of shelled Comp.B explosive was studied following the Lee-Tarver ignition and growth model when it was impacted respectively by 4340 Steel, OFHC and 93#W projectile with the same mass; the influences on explosive detonation of the initiation process, the material of projectile and the L/D ratio of projectile were analyzed; the critical initiation speeds of the projectiles of three different materials with different L/D ratio were gained. In order to verify the simulation results, the questions were calculated by the theoretical simplified model, the results of the theoretical calculation and the numerical simulation accorded well based on critical energy criterion. The results show that the capability of igniting explosive, the first is 93#W, the second is OFHC, the last is 4340 Steel; The initiation point were not on the interface of shell and explosive, and the faster of the impacting velocity, the initiation point closer the interface; the bigger of the L/D ratio of projectile, the higher of the critical initiation speed.

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C5.3 - Sonographic Detection of Nanoparticles used for Magnetic Drug Targeting

10.5162/sensor2015/c5.3 ◽

2015 ◽

Author(s):

M. Fink ◽

H. Ermert ◽

M Löffler ◽

A. Sutor ◽

B. Tewes ◽

...

Keyword(s):

Drug Targeting ◽

Magnetic Drug Targeting

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Intrathecal Magnetic Drug Targeting: A New Approach to Treating Diseases of the Central Nervous System

ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology ◽

10.1115/nemb2013-93117 ◽

2013 ◽

Author(s):

Eric Lueshen ◽

Indu Venugopal ◽

Andreas Linninger

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Central Nervous System ◽

Nervous System ◽

Spinal Canal ◽

Drug Targeting ◽

Superparamagnetic Nanoparticles ◽

Magnetic Drug Targeting ◽

The Central Nervous System ◽

Drug Doses

Intrathecal (IT) drug delivery is a standard technique which involves direct injection of drugs into the cerebrospinal fluid (CSF)-filled space within the spinal canal to treat many diseases of the central nervous system. Currently, in order to reach the therapeutic drug concentration at certain locations within the spinal canal, high drug doses are used. With no method to deliver the large drug doses locally, current IT drug delivery treatments are hindered with wide drug distributions throughout the central nervous system (CNS) which cause harmful side effects. In order to overcome the current limitations of IT drug delivery, we have developed the novel method of intrathecal magnetic drug targeting (IT-MDT). Gold-coated magnetite nanoparticles are infused into a physiologically and anatomically relevant in vitro human spine model and then targeted to a specific site using external magnetic fields, resulting in a substantial increase in therapeutic nanoparticle localization at the site of interest. Experiments aiming to determine the effect of key parameters such as magnet strength, duration of magnetic field exposure, location of magnetic field, and ferrous implants on the collection efficiency of our superparamagnetic nanoparticles in the targeting region were performed. Our experiments indicate that intrathecal magnetic drug targeting and implant-assisted IT-MDT are promising techniques for concentrating and localizing drug-functionalized nanoparticles at required target sites within the spinal canal for potential treatment of diseases affecting the central nervous system.

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