Targeted Tumor Therapy with “Magnetic Drug Targeting”: Therapeutic Efficacy of Ferrofluid Bound Mitoxantrone

2002 ◽  
pp. 233-251 ◽  
Author(s):  
Ch. Alexiou ◽  
R. Schmid ◽  
R. Jurgons ◽  
Ch. Bergemann ◽  
W. Arnold ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Drug Targeting ◽  
Tumor Therapy ◽  
Magnetic Drug Targeting

Magnetic drug targeting: biokinetic study and therapeutic efficacy

2001 ◽  
Vol 37 ◽  
pp. S11
Author(s):  
Ch. Alexiou ◽  
P. Hulin ◽  
R. Klein ◽  
A. Schmidt ◽  
Ch. Bergemann ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Drug Targeting ◽  
Magnetic Drug Targeting

scholarly journals Mitoxantrone Loaded Superparamagnetic Nanoparticles for Drug Targeting: A Versatile and Sensitive Method for Quantification of Drug Enrichment in Rabbit Tissues Using HPLC-UV

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Rainer Tietze ◽  
Eveline Schreiber ◽  
Stefan Lyer ◽  
Christoph Alexiou
Keyword(s):  
Drug Targeting ◽  
Tumor Therapy ◽  
Region Of Interest ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Drug Targeting ◽  
Complex Matrix ◽  
Limit Of Quantification ◽  
Biodistribution Studies ◽  
Validation Criteria ◽  
High Yields

In medicine, superparamagnetic nanoparticles bound to chemotherapeutics are currently investigated for their feasibility in local tumor therapy. After intraarterial application, these particles can be accumulated in the targeted area by an external magnetic field to increase the drug concentration in the region of interest (Magnetic-Drug-Targeting). We here present an analytical method (HPLC-UV), to detect pure or ferrofluid-bound mitoxantrone in a complex matrix even in trace amounts in order to perform biodistribution studies. Mitoxantrone could be extracted in high yields from different tissues. Recovery of mitoxantrone in liver tissue (5000 ng/g) was76±2%. The limit of quantification of mitoxantrone standard was 10 ng/mL±12%. Validation criteria such as linearity, precision, and stability were evaluated in ranges achieving the FDA requirements. As shown for pilot samples, biodistribution studies can easily be performed after application of pure or ferrofluid-bound mitoxantrone.

scholarly journals In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

2020 ◽  
Vol 6 (3) ◽  
pp. 543-546
Author(s):  
Michael Fink ◽  
Stefan J. Rupitsch ◽  
Helmut Ermert ◽  
Stefan Lyer
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Imaging Technique ◽  
Small Animal ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Medical Procedures ◽  
First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

scholarly journals C5.3 - Sonographic Detection of Nanoparticles used for Magnetic Drug Targeting

2015 ◽  
Author(s):  
M. Fink ◽  
H. Ermert ◽  
M Löffler ◽  
A. Sutor ◽  
B. Tewes ◽  
...  
Keyword(s):  
Drug Targeting ◽  
Magnetic Drug Targeting

Intrathecal Magnetic Drug Targeting: A New Approach to Treating Diseases of the Central Nervous System

2013 ◽  
Author(s):  
Eric Lueshen ◽  
Indu Venugopal ◽  
Andreas Linninger
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Spinal Canal ◽  
Drug Targeting ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Drug Targeting ◽  
The Central Nervous System ◽  
Drug Doses

Intrathecal (IT) drug delivery is a standard technique which involves direct injection of drugs into the cerebrospinal fluid (CSF)-filled space within the spinal canal to treat many diseases of the central nervous system. Currently, in order to reach the therapeutic drug concentration at certain locations within the spinal canal, high drug doses are used. With no method to deliver the large drug doses locally, current IT drug delivery treatments are hindered with wide drug distributions throughout the central nervous system (CNS) which cause harmful side effects. In order to overcome the current limitations of IT drug delivery, we have developed the novel method of intrathecal magnetic drug targeting (IT-MDT). Gold-coated magnetite nanoparticles are infused into a physiologically and anatomically relevant in vitro human spine model and then targeted to a specific site using external magnetic fields, resulting in a substantial increase in therapeutic nanoparticle localization at the site of interest. Experiments aiming to determine the effect of key parameters such as magnet strength, duration of magnetic field exposure, location of magnetic field, and ferrous implants on the collection efficiency of our superparamagnetic nanoparticles in the targeting region were performed. Our experiments indicate that intrathecal magnetic drug targeting and implant-assisted IT-MDT are promising techniques for concentrating and localizing drug-functionalized nanoparticles at required target sites within the spinal canal for potential treatment of diseases affecting the central nervous system.

Magnetic drug targeting

2021 ◽  
pp. 171-216
Author(s):  
Alexandru Morega ◽  
Mihaela Morega ◽  
Alin Dobre
Keyword(s):  
Drug Targeting ◽  
Magnetic Drug Targeting

scholarly journals Advances in nanomaterials for treatment of hypoxic tumor

2020 ◽  
Author(s):  
Mei-Zhen Zou ◽  
Wen-Long Liu ◽  
Han-Shi Chen ◽  
Xue-Feng Bai ◽  
Fan Gao ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
High Mortality ◽  
Therapeutic Efficacy ◽  
Tumor Invasion ◽  
Tumor Recurrence ◽  
Tumor Therapy ◽  
Functional Nanomaterials ◽  
Oxygen Levels ◽  
Hypoxic Conditions ◽  
Hypoxic Tumor

Abstract The hypoxic tumor microenvironment is characterized by disordered vasculature and rapid proliferation of tumors, resulting from tumor invasion, progression and metastasis. The hypoxic conditions restrict efficiency of tumor therapies, such as chemotherapy, radiotherapy, phototherapy and immunotherapy, leading to serious results of tumor recurrence and high mortality. Recently, research has concentrated on developing functional nanomaterials to treat hypoxic tumors. In this review, we categorize such nanomaterials into (i) nanomaterials that elevate oxygen levels in tumors for enhanced oxygen-dependent tumor therapy and (ii) nanomaterials with diminished oxygen dependence for hypoxic tumor therapy. To elevate oxygen levels in tumors, oxygen-carrying nanomaterials, oxygen-generating nanomaterials and oxygen-economizing nanomaterials can be used. To diminish oxygen dependence of nanomaterials for hypoxic tumor therapy, therapeutic gas-generating nanomaterials and radical-generating nanomaterials can be used. The biocompatibility and therapeutic efficacy of these nanomaterials are discussed.

scholarly journals Quantitative Imaging of the Iron-Oxide Nanoparticle- Concentration for Magnetic Drug Targeting Employing Inverse Magnetomotive Ultrasound

2019 ◽  
Vol 5 (1) ◽  
pp. 417-419 ◽  
Author(s):  
Michael Fink ◽  
Stefan Lyer ◽  
Christoph Alexiou ◽  
Stefan J. Rupitsch ◽  
Helmut Ermert
Keyword(s):  
Drug Targeting ◽  
Magnetic Nanoparticle ◽  
Particle Concentration ◽  
Quantitative Imaging ◽  
Simulated Data ◽  
Magnetic Drug Targeting ◽  
Iron Oxide Nanoparticle ◽  
Order Of Magnitude ◽  
Oxide Nanoparticle

AbstractMagnetomotive Ultrasound is an imaging technique that is capable to detect tissue, which is perfused by magnetic nanoparticles. However, this modality is restricted to qualitative imaging only. Therefore, we present an extended Magnetomotive Ultrasound algorithm, which allows the quantitative determination of the spatial distribution of magnetic nanoparticle density in tissue. The algorithm is based on an iterative adjustment of simulated data to measurements. Experiments with tissue-mimicking phantoms reveal that the presented method leads to the spatial particle concentration in the correct order of magnitude.

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