scholarly journals Design of sporopollenin-based functional ingredients for gastrointestinal tract targeted delivery

2022 ◽  
pp. 100809
Author(s):  
Pien JC Schouten ◽  
Diana Soto-Aguilar ◽  
Ali Aldalbahi ◽  
Tansir Ahamad ◽  
Shaykha Alzahly ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Targeted Delivery ◽  
Functional Ingredients

scholarly journals Influence of functional ingredients of baby food on immunity

2019 ◽  
pp. 37-44
Author(s):  
О. N. Komarova ◽  
A. I. Khavkin
Keyword(s):  
Fatty Acids ◽  
Gastrointestinal Tract ◽  
Intestinal Microbiota ◽  
Antibacterial Therapy ◽  
Immunoglobulin A ◽  
Short Chain Fatty Acids ◽  
Overweight And Obesity ◽  
Functional Ingredients ◽  
Balanced Diet ◽  
Colonization Potential

In order to prevent the development of chronic diseases, including cardiovascular diseases, overweight and obesity, diabetes mellitus, cancer and allergic pathology, it is necessary to adhere to a balanced diet from an early age, with the inclusion of functional ingredients, including dietary fiber, vitamins and vitamin-like compounds, minerals, polyunsaturated fatty acids, prebiotics and probiotics. Combined enrichment of dairy products with prebiotics and probiotics helps to combine their positive and effective impacts. There has been an improvement in the survival of probiotic microorganisms in the gastrointestinal tract (GIT). It has been shown that the addition of prebiotics and probiotics to the diet helps to change the composition of the intestinal microbiota towards a more balanced structure, thereby increasing the barrier function of the intestine and the formation of optimal immune interactions. The general effects of prebiotics and probiotics include maintaining homeostasis and integrity of the intestinal mucosa, providing colonization potential for pathogens, production of short-chain fatty acids and vitamins, metabolism of bile acids, regulation of transit through the gastrointestinal tract, and increased regeneration of enterocytes. The combination of bifidobacteria or lactobacteria with fructo-oligosaccharides in symbiotic products is most commonly used in human nutrition. In our study, patients aged 8 to 18 months, reconvalescents of acute respiratory disease for which antibacterial therapy was prescribed, included in their diet for 3 months drinking yoghurts enriched with Bifidobacterium Lactis BB12 and inulin. Inclusion of yoghurt in the diet of children contributed to the normalization of intestinal microbiota composition after antibacterial therapy, as well as strengthening immunity by stimulating the synthesis of protective factors secretory immunoglobulin A and lysozyme.

Microencapsulated bile salt hydrolase producing Lactobacillus reuteri for oral targeted delivery in the gastrointestinal tract

2008 ◽  
Vol 81 (2) ◽  
pp. 225-233 ◽  
Author(s):  
Christopher Martoni ◽  
Jasmine Bhathena ◽  
Aleksandra Malgorzata Urbanska ◽  
Satya Prakash
Keyword(s):  
Gastrointestinal Tract ◽  
Bile Salt ◽  
Targeted Delivery ◽  
Lactobacillus Reuteri ◽  
Bile Salt Hydrolase

scholarly journals Preparation andIn VitroRelease of Drug-Loaded Microparticles for Oral Delivery Using Wholegrain Sorghum Kafirin Protein

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Esther T. L. Lau ◽  
Stuart K. Johnson ◽  
Roger A. Stanley ◽  
Deirdre Mikkelsen ◽  
Zhongxiang Fang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gastrointestinal Tract ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Oral Delivery ◽  
Protein Digestibility ◽  
Target Area ◽  
Sorghum Grains

Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an oral delivery system. Targeted delivery to the colon would be beneficial for medication such as prednisolone, which is used in the management of inflammatory bowel disease. Therefore, prednisolone was loaded into microparticles of kafirin from the different sources using phase separation. Differences were observed in the protein content,in vitroprotein digestibility, and protein electrophoretic profile of the various sources of sorghum grains, kafirin extracts, and kafirin microparticles. For all of the formulations, the majority of the loaded prednisolone was not released inin vitroconditions simulating the upper gastrointestinal tract, indicating that most of the encapsulated drug could reach the target area of the lower gastrointestinal tract. This suggests that these kafirin microparticles may have potential as a colon-targeted nutraceutical and drug delivery system.

scholarly journals Study of the Potential of the Capsule Shell Based on Natural Polysaccharides in Targeted Delivery of the L-Phenylalanine Ammonia-Lyase Enzyme Preparation

2020 ◽  
Vol 13 (4) ◽  
pp. 63
Author(s):  
Olga Babich ◽  
Lyubov Dyshlyuk ◽  
Alexander Prosekov ◽  
Svetlana Noskova ◽  
Oksana Ivina ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Targeted Delivery ◽  
Enzyme Preparation ◽  
Phenylalanine Ammonia Lyase ◽  
Simulated Intestinal Fluid ◽  
Temperature Oxidation ◽  
Enzyme Preparations ◽  
Capsule Shell ◽  
Wide Range

The treatment of classical phenylketonuria is currently represented by many new methods of disease management. A promising method is the use of the enzyme L-phenylalanine ammonia-lyase (PAL) in various forms. The widespread use of enzyme preparations in therapy is limited by a lack of understanding of the mechanisms and systems of the targeted transport of PAL into certain organs and tissues as a result of the incorporation of a drug into the carrier. To ensure the stability of enzymes during the delivery process, encapsulation is preferable, which, as a rule, ensures the preservation of the qualitative characteristics of the enzymes orally applied to the environmental effects of the gastrointestinal tract (acidity, temperature, oxidation, etc.). Capsule preparations showed sufficient stability in the model gastric fluids and sustained release of the drug in the simulated intestinal fluid. Currently, there is a wide range of polymers used for encapsulation. The use of natural sources in the production technology of capsule systems improves bioavailability, controls the release, and prolongs the half-life of active substances. The advantage of this method is that the used enzyme is completely protected by the cell membranes of the capsules, which preserve its stability in the aggressive environment of the gastrointestinal tract. Capsules were obtained on the basis of compositions of hydrocolloids of plant origin. The potential of the developed capsules for targeted delivery of the enzyme preparation was studied. The degradation of the encapsulated form of the PAL enzyme preparation was studied in vitro in model bio-relevant media simulating the gastric and intestinal environment. The dynamics of the breakdown of the capsule shell allow us to expect that the release of L-phenylalanine ammonia-lyase from capsules based on plant hydrocolloids will occur no earlier than reaching the upper intestines, where the interaction with the protein components of the consumed food products to neutralize phenylalanine should occur.

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