Membrane protein resistance of oligo(ethylene oxide) self-assembled monolayers

2014 ◽  
Vol 122 ◽  
pp. 552-558 ◽  
Author(s):  
Amit Vaish ◽  
David J. Vanderah ◽  
Ryan Vierling ◽  
Fay Crawshaw ◽  
D. Travis Gallagher ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Ethylene Oxide ◽  
Self Assembled Monolayers ◽  
Protein Resistance ◽  
Assembled Monolayers ◽  
Self Assembled

Synthesis and Characterization of Self-Assembled Monolayers of Alkylated 1-Thiahexa(ethylene oxide) Compounds on Gold

Langmuir ◽  
1998 ◽  
Vol 14 (24) ◽  
pp. 6916-6923 ◽  
Author(s):  
David J. Vanderah ◽  
Curtis W. Meuse ◽  
Vitalii Silin ◽  
Anne L. Plant
Keyword(s):  
Ethylene Oxide ◽  
Self Assembled Monolayers ◽  
Synthesis And Characterization ◽  
Assembled Monolayers ◽  
Self Assembled

Self-Assembled Monolayers as Models for Studying Protein Adsorption to Polymer Surfaces

1991 ◽  
Vol 237 ◽  
Author(s):  
Kevin L. Prime ◽  
George M. Whttesides
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Organic Materials ◽  
Polymer Surfaces ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Protein Resistant ◽  
Poly Ethylene

ABSTRACTSelf-assembled monolayers (SAMs) of functionalized alkanethiolates on gold are a well-characterized system for studying the interfacial properties of organic materials. We have used SAMs as models for the surfaces of organic polymers and used mem to study the adsorption of proteins onto organic materials. We have formed SAMs from mixtures of alkanethiols in which one alkanethiol is hydrophobic and the other is terminated by a short (2 ≤ n ≤ 17) oligomer of poly(ethylene oxide). These “mixed” SAMs effectively resist the adsorption of fibrinogen from moderately concentrated (1 mg/mL) solutions. Protein adsorption begins when < 5% of the accessible area of the surface consists of hydrophobic groups. These findings suggest that real protein-resistant monolayers must present an almost defect-free surface of oligo(ethylene oxide) groups in order to eliminate adsorption.

Sign in / Sign up

Export Citation Format

Share Document