Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway

2020 ◽  
Vol 187 ◽  
pp. 110647 ◽  
Author(s):  
Peng Zhang ◽  
Libang He ◽  
Jie Zhang ◽  
Xifan Mei ◽  
Yiyao Zhang ◽  
...  
Keyword(s):  
Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1872
Author(s):  
Hamideh Afzali ◽  
Mohammad Khaksari ◽  
Sajad Jeddi ◽  
Khosrow Kashfi ◽  
Mohammad-Amin Abdollahifar ◽  
...  

Impaired skin nitric oxide production contributes to delayed wound healing in type 2 diabetes (T2D). This study aims to determine improved wound healing mechanisms by acidified nitrite (AN) in rats with T2D. Wistar rats were assigned to four subgroups: Untreated control, AN-treated control, untreated diabetes, and AN-treated diabetes. AN was applied daily from day 3 to day 28 after wounding. On days 3, 7, 14, 21, and 28, the wound levels of vascular endothelial growth factor (VEGF) were measured, and histological and stereological evaluations were performed. AN in diabetic rats increased the numerical density of basal cells (1070 ± 15.2 vs. 936.6 ± 37.5/mm3) and epidermal thickness (58.5 ± 3.5 vs. 44.3 ± 3.4 μm) (all p < 0.05); The dermis total volume and numerical density of fibroblasts at days 14, 21, and 28 were also higher (all p < 0.05). The VEGF levels were increased in the treated diabetic wounds at days 7 and 14, as was the total volume of fibrous tissue and hydroxyproline content at days 14 and 21 (all p < 0.05). AN improved diabetic wound healing by accelerating the dermis reconstruction, neovascularization, and collagen deposition.


2013 ◽  
Vol 15 (4) ◽  
pp. 210-216 ◽  
Author(s):  
Andreia Aparecida Da Silva ◽  
Ernesto Cesar Pinto Leal-Junior ◽  
Ana Carolina Araruna Alves ◽  
Caroline Sobral Rambo ◽  
Solange Almeida Dos Santos ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Teoh Seong Lin ◽  
Azian Abd Latiff ◽  
Noor Aini Abd Hamid ◽  
Wan Zurinah bt Wan Ngah ◽  
Musalmah Mazlan

2009 ◽  
Vol 27 (4) ◽  
pp. 607-610 ◽  
Author(s):  
Metin Güngörmüş ◽  
Utkan Kamil Akyol
Keyword(s):  

2014 ◽  
Vol 35 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Gladys Lai-Ying Cheing ◽  
Xiaohui Li ◽  
Lin Huang ◽  
Rachel Lai-Chu Kwan ◽  
Kwok-Kuen Cheung

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