Effect of Hydroalcoholic Extract of Teucrium polium on the Process of Wound Healing in Diabetic Rats

passer ◽  
2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Mohsin Salih
Keyword(s):  
Wound Healing ◽  
Diabetic Rats ◽  
Hydroalcoholic Extract ◽  
Teucrium Polium

Topical Application of Teucrium polium Can Improve Wound Healing in Diabetic Rats

2019 ◽  
Vol 19 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Hasan Fallah Huseini ◽  
Amir Hossein Abdolghaffari ◽  
Maryam Ahwazi ◽  
Eghbal Jasemi ◽  
Maryam Yaghoobi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Rats ◽  
Control Group ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Teucrium Polium

Diabetic foot ulcer is one of the major complications among diabetic patients. Several studies have shown that the extract of Teucrium polium (T. polium) is effective in the treatment of diabetic and non-diabetic wounds, as well as burn wounds. The aim of current study was to assess the wound healing activity of T. polium extract ointment in diabetic rats. Sixty-four male Wistar rats were induced diabetes with alloxan injection (125 mg/kg) and surgical wound induced. The rats were divided into 8 groups of eight rats each: control group, eucerin group, phenytoin group, 2%, 3%, 4%, 5% and 10% T. polium groups. The ointment was dressed on the wound twice a day. The process of wound healing was screened by macroscopy and digitalization on days 14 and 21 and until complete wound healing. There was no infection in the wounds of rats in any groups. The process of wounds healing of the 2%, 3%, 4%, 5%, and 10% T. polium ointments, with phenytoin ointment and base ointment (eucerin) on day 14 and 21, showed that the significant difference between the treatment groups with 4% (P = 0.003), 5% (P = 0.001), 10% (P = 0.001) T. polium ointment and phenytoin ointment group (P = 0.001) compared to eucerin group. The results of this study showed that T. polium extract ointment with a 10% ointment accelerates the wound healing process in diabetic rats and is comparable to the phenytoin group.

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals Acidified Nitrite Accelerates Wound Healing in Type 2 Diabetic Male Rats: A Histological and Stereological Evaluation

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1872
Author(s):  
Hamideh Afzali ◽  
Mohammad Khaksari ◽  
Sajad Jeddi ◽  
Khosrow Kashfi ◽  
Mohammad-Amin Abdollahifar ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fibrous Tissue ◽  
Diabetic Rats ◽  
Male Rats ◽  
Numerical Density ◽  
Basal Cells ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds ◽  
Endothelial Growth Factor

Impaired skin nitric oxide production contributes to delayed wound healing in type 2 diabetes (T2D). This study aims to determine improved wound healing mechanisms by acidified nitrite (AN) in rats with T2D. Wistar rats were assigned to four subgroups: Untreated control, AN-treated control, untreated diabetes, and AN-treated diabetes. AN was applied daily from day 3 to day 28 after wounding. On days 3, 7, 14, 21, and 28, the wound levels of vascular endothelial growth factor (VEGF) were measured, and histological and stereological evaluations were performed. AN in diabetic rats increased the numerical density of basal cells (1070 ± 15.2 vs. 936.6 ± 37.5/mm3) and epidermal thickness (58.5 ± 3.5 vs. 44.3 ± 3.4 μm) (all p < 0.05); The dermis total volume and numerical density of fibroblasts at days 14, 21, and 28 were also higher (all p < 0.05). The VEGF levels were increased in the treated diabetic wounds at days 7 and 14, as was the total volume of fibrous tissue and hydroxyproline content at days 14 and 21 (all p < 0.05). AN improved diabetic wound healing by accelerating the dermis reconstruction, neovascularization, and collagen deposition.

Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway

2020 ◽  
Vol 187 ◽  
pp. 110647 ◽  
Author(s):  
Peng Zhang ◽  
Libang He ◽  
Jie Zhang ◽  
Xifan Mei ◽  
Yiyao Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Rats
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