Green synthesis, formulation and biological evaluation of a novel ZnO nanocarrier loaded with paclitaxel as drug delivery system on MCF-7 cell line

2020 ◽  
Vol 186 ◽  
pp. 110686 ◽  
Author(s):  
Maedeh Akbarian ◽  
Soleiman Mahjoub ◽  
Seyed Mohammad Elahi ◽  
Ebrahim Zabihi ◽  
Hamed Tashakkorian
Keyword(s):  
Drug Delivery ◽  
Green Synthesis ◽  
Cell Line ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Evaluation ◽  
Mcf 7

Lignin-graft-PLGA drug-delivery system improves efficacy of MEK1/2 inhibitors in triple-negative breast cancer cell line

Nanomedicine ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. 981-1000
Author(s):  
C Ethan Byrne ◽  
Carlos E Astete ◽  
Manibarathi Vaithiyanathan ◽  
Adam T Melvin ◽  
Mahsa Moradipour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cell Line ◽  
Drug Delivery System ◽  
Delivery System ◽  
Triple Negative Breast Cancer ◽  
Targeted Therapies ◽  
Triple Negative ◽  
Mesenchymal Transition

Aim: Few targeted therapies are available for triple-negative breast cancer (TNBC) patients. Here, we propose a novel alkaline-lignin-conjugated-poly(lactic- co-glycolic acid) (L-PLGA) nanoparticle drug delivery system to improve the efficacy of targeted therapies. Materials & methods: L-PLGA nanoparticles (NPs) loaded with the MEK1/2 inhibitor GDC-0623 were characterized, tested in vitro on MDA-MB-231 TNBC cell line and compared with loaded PLGA NPs. Results: Loaded L-PLGA NPs were less than half the size of PLGA NPs, had slower drug release and improved the efficacy of GDC-0623 when tested in vitro. We demonstrated that GDC-0623 reversed epithelial-to-mesenchymal transition in TNBC. Conclusion: Our findings indicate that L-PLGA NPs are superior to PLGA NPs in delivering GDC-0623 to cancer cells for improved efficacy in vitro.

scholarly journals Novel and green synthesis of a nanopolymer and its use as a drug delivery system of silibinin and silymarin extracts in the olfactory ensheathing cells of rats in normal and high-glucose conditions

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 38912-38927 ◽  
Author(s):  
Sabah Shiri ◽  
Naser Abbasi ◽  
Kamal Alizadeh ◽  
Elahe Karimi
Keyword(s):  
Drug Delivery ◽  
Green Synthesis ◽  
Drug Delivery System ◽  
Delivery System ◽  
High Glucose ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

A schematic of a new synthesized nanopolymer (CGONP) and its use as a drug delivery system of silibinin and silymarin extract in the olfactory ensheathing cells (OECs) of rats in normal and high-glucose conditions.

Cross-Linked Small-Molecule Micelle-Based Drug Delivery System: Concept, Synthesis, and Biological Evaluation

2016 ◽  
Vol 28 (21) ◽  
pp. 7757-7764 ◽  
Author(s):  
Chunyan Liao ◽  
Yun Chen ◽  
Yongchao Yao ◽  
Shiyong Zhang ◽  
Zhongwei Gu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Molecule ◽  
Biological Evaluation ◽  
System Concept ◽  
Synthesis And Biological Evaluation
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