scholarly journals Phenolic composition of peels from different Jaboticaba species determined by HPLC-DAD-ESI/MSn and antiproliferative activity in tumor cell lines

2021 ◽  
pp. 100233
Author(s):  
Michelly Cristiane Paludo ◽  
Silvia Borges Pimentel de Oliveira ◽  
Luciana Fontes de Oliveira ◽  
Ronan Carlos Colombo ◽  
Sergio Gómez-Alonso ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Phenolic Composition

scholarly journals Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines

2008 ◽  
Vol 56 (3) ◽  
pp. 179-185 ◽  
Author(s):  
Hamideh Ghodrati Azadi ◽  
Seyed Mahmood Ghaffari ◽  
Gholam Hossein Riazi ◽  
Shahin Ahmadian ◽  
Fatemeh Vahedi
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Allium Hirtifolium

Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines

2010 ◽  
Vol 20 (5) ◽  
pp. 1504-1506 ◽  
Author(s):  
Simonas Rudys ◽  
Carla Ríos-Luci ◽  
Eduardo Pérez-Roth ◽  
Inga Cikotiene ◽  
José M. Padrón
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Human Solid Tumor

scholarly journals Lipophilic Salirasib analogs with enhanced antiproliferative activity against human solid tumor cell lines

2021 ◽  
Author(s):  
Exequiel O. J. Porta ◽  
María Sol Ballari ◽  
José M. Padrón ◽  
Guillermo R. Labadie
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Cancer Cell ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
In Silico ◽  
Tumor Cell Lines ◽  
Human Solid Tumor ◽  
Physicochemical Features ◽  
Sar Analysis

Aim: We proposed to determine the antiproliferative activity of a series of synthetic salirasib analogs, presenting or not a 1,2,3-triazole linker, against five different cancer cell lines. Results: Bioassay, cheminformatic, and in silico ADME-Tox allowed the identification of new potent analogs. SAR analysis allowed the identification of structural and physicochemical features that benefit the antiproliferative activity. Conclusion: Isoprenyl R chains with three or more isoprene units, or long aliphatic R chains are the preferred ones within the active compounds. Likewise, we have identified three compounds with better activity profiles than salirasib against all the cell lines tested.

Synthesis, structural characterization and antiproliferative activity on MCF-7 and A549 tumor cell lines of [Cu(N-N)(β3-aminoacidate)]NO3 complexes (Casiopeínas®)

2020 ◽  
Vol 506 ◽  
pp. 119542 ◽  
Author(s):  
Jonathan Román Valdez-Camacho ◽  
Yaquelinne Pérez-Salgado ◽  
Adrián Espinoza-Guillén ◽  
Virginia Gómez-Vidales ◽  
Carlos Alberto Tavira-Montalvan ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Structural Characterization ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Mcf 7

scholarly journals Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 4005
Author(s):  
Simayijiang Aimaiti ◽  
Yohei Saito ◽  
Shuichi Fukuyoshi ◽  
Masuo Goto ◽  
Katsunori Miyake ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Optical Rotation ◽  
Human Tumor ◽  
Tumor Cell Line ◽  
2D Nmr ◽  
Significant Activity ◽  
Tumor Cell Lines

Seven new butanolides, peltanolides A–G (1–7), and two lignan glucosides, peltasides A (8) and B (9), along with eleven known compounds, 10–20, were isolated from a crude CH3OH/CH2Cl2 (1:1) extract of the fruit of Hernandia nymphaeifolia (Hernandiaceae). The structures of 1–9 were characterized by extensive 1D and 2D NMR spectroscopic and HRMS analysis. The absolute configurations of newly isolated compounds 1–9 were determined from data obtained by optical rotation and electronic circular dichroism (ECD) exciton chirality methods. Butanolides and lignan glucosides have not been isolated previously from this genus. Several isolated compounds were evaluated for antiproliferative activity against human tumor cell lines. Lignans 15 and 16 were slightly active against chemosensitive tumor cell lines A549 and MCF-7, respectively. Furthermore, both compounds displayed significant activity (IC50 = 5 µM) against a P-glycoprotein overexpressing multidrug-resistant tumor cell line (KB-VIN) but were less active against its parent chemosensitive cell line (KB).

scholarly journals Antiproliferative activity in tumor cell lines, antioxidant capacity and total phenolic, flavonoid and tannin contents of Myrciaria floribunda

2017 ◽  
Vol 89 (2) ◽  
pp. 1111-1120 ◽  
Author(s):  
LUIS A.C. TIETBOHL ◽  
ADRIANA P. OLIVEIRA ◽  
RICARDO S. ESTEVES ◽  
RICARDO D.D.G. ALBUQUERQUE ◽  
DIOGO FOLLY ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Antioxidant Capacity ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Total Phenolic ◽  
Tumor Cell Lines

scholarly journals Antiproliferative Activity of Cucurbitaceae Species Extracts from Southeast of Mexico

2019 ◽  
Author(s):  
Karen Morales-Vela ◽  
Flor Celeste Pérez-Sánchez ◽  
Jose M. Padron ◽  
Olivia Márquez-Fernández
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell Lines ◽  
Organic Extracts ◽  
Different Types ◽  
A549 Lung

There are many species of endemic plants from Mexico, without food or commercial use, but with different applications in traditional medicine and valuable for their content of secondary metabolites. In this sense, we found two species of Cucurbitacea family plants natives of southeast and gulf of México, with traditionally use how soap and laundry agent, control of some pests, and it has also been used how infusion for the treatment of different types of dermatitis and stomachache. In the present work, we evaluate the antiproliferative activity in vitro, of six crude organic extracts, tested against six human tumor cell lines, A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast) and WiDr (colon), the results indicated that at least three extracts from both species presents an interesting antiproliferative activity on five tumor cell lines.

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