Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancer

2008 ◽  
Vol 68 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Manuela Gago-Dominguez ◽  
Jose Esteban Castelao
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Thyroid Diseases ◽  
And Oxidative Stress

Proteasome activity in experimental diabetes

2006 ◽  
Vol 1 (2) ◽  
pp. 289-298 ◽  
Author(s):  
Albena Alexandrova ◽  
Lubomir Petrov ◽  
Margarita Kirkova
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Protein Oxidation ◽  
Experimental Diabetes ◽  
Diabetic Rats ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
And Oxidative Stress

AbstractNumerous studies have indicated that oxidative stress contributes to the development and progression of diabetes and other related complications. Since the ubiquitin-proteasome pathway is involved in degradation of oxidized proteins, it is to be expected that alterations in proteasome-dependent proteolysis accompany diabetes. This paper focuses on the role of the proteasome in alloxan-induced experimental diabetes. The changes in proteasomal activity and oxidative stress indices (protein oxidation and lipid peroxidation) were evaluated. The obtained results revealed increased protein oxidation and lipid peroxidation, as well as alterations in proteasomal activities in diabetic rats. Our data indicates a significant decrease in chymotryptic-like activity; increased tryptic-like activity; and unchanged post-glutamyl peptide hydrolytic-like activity. These findings suggest the presence of oxidative stress in diabetes that appears to result in changes to the ubiquitin-proteasome pathway.

The Role of Oxidative Stress Modulators in Breast Cancer

2018 ◽  
Vol 25 (33) ◽  
pp. 4084-4101 ◽  
Author(s):  
Hande Gurer-Orhan ◽  
Elif Ince ◽  
Dilan Konyar ◽  
Luciano Saso ◽  
Sibel Suzen
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Cells ◽  
Oxidative Status ◽  
Cancer Site ◽  
International Agency ◽  
Antioxidant Defence ◽  
Impaired Balance ◽  
And Oxidative Stress

Background: Latest data from International Agency for Cancer Research shows that breast cancer is the leading cancer site in women and is the leading cause of death among female cancers. Induction of reactive oxygen species (ROS) and oxidative stress as a consequence of impaired balance between prooxidants and antioxidants are suggested to be involved in induction and progression of breast cancer. Cancer cells are found to exhibit higher levels of ROS compared to normal cells. However increased antioxidant defence which balances the oxidative status within the cancer cells suggests that high ROS levels may prevent tumorigenesis via various mechanisms. These contradictory roles of ROS and oxidative stress in breast cancer let scientists investigate potential oxidative stress modulators as anticancer strategies. Conclusions: In the present review we address the mechanisms of ROS production in breast cancer cells, the role of impaired oxidative status as well as the benefits of introducing oxidative stress modulators in therapeutic strategies in breast cancer. This review is focusing more on melatonin which we have been working on during the last decade. Our data, in accordance with the literature, suggest an important role for melatonin in breast cancer prevention and adjuvant therapy.

scholarly journals The 8-epimer of prostaglandin F2α, a marker of lipid peroxidation and oxidative stress, is decreased in the nipple aspirate fluid of women with breast cancer

2007 ◽  
Vol 120 (9) ◽  
pp. 1971-1976 ◽  
Author(s):  
Ferdinando Mannello ◽  
Gaetana A.M. Tonti ◽  
Silvia Pagliarani ◽  
Serena Benedetti ◽  
Franco Canestrari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Prostaglandin F2α ◽  
Nipple Aspirate Fluid ◽  
And Oxidative Stress

scholarly journals Role of inflammation and oxidative stress in post-menopausal oestrogen-dependent breast cancer

2014 ◽  
Vol 18 (12) ◽  
pp. 2519-2529 ◽  
Author(s):  
Clelia Madeddu ◽  
Giulia Gramignano ◽  
Carlo Floris ◽  
Giuseppe Murenu ◽  
Giuseppe Sollai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Post Menopausal ◽  
And Oxidative Stress

scholarly journals Prospects for the Role of Ferroptosis in Fluorosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yi Zhang ◽  
Jialong Wu ◽  
Lai Jiang ◽  
Chenkang Lu ◽  
Zhengwei Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Cellular Damage ◽  
Oxygen Species ◽  
Membrane Rupture ◽  
High Fluoride ◽  
And Oxidative Stress ◽  
Dependent Type

As a strong oxidant, fluorine can induce oxidative stress resulting in cellular damage. Ferroptosis is an iron-dependent type of cell death caused by unrestricted lipid peroxidation (LPO) and subsequent plasma membrane rupture. This article indicated a relationship between fluorosis and ferroptosis. Evidence of the depletion of glutathione (GSH) and increased oxidized GSH can be found in a variety of organisms in high fluorine environments. Studies have shown that high fluoride levels can reduce the antioxidant capacity of antioxidant enzymes, while increasing the contents of reactive oxygen species (ROS) and malondialdehyde (MDA), resulting in oxidative stress and fluoride-induced oxidative stress, which are related to iron metabolism disorders. Excessive fluorine causes insufficient GSH, glutathione peroxidase (GSH-Px) inhibition, and oxidative stress, resulting in ferroptosis, which may play an important role in the occurrence and development of fluorosis.

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