Bone Marrow/Bone Pre-Metastatic Niche For Breast Cancer Cells Colonization: The Role Of Mesenchymal Stromal Cells

2021 ◽  
pp. 103416
Author(s):  
M.C. Sanmartin ◽  
F.R. Borzone ◽  
M.B. Giorello ◽  
N. Pacienza ◽  
G. Yannarelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Metastatic Niche

Breast cancer cells and bone marrow mesenchymal stromal cells: a regulated modulation of the breast tumor in the context of immune response

2016 ◽  
Vol 66 (2) ◽  
pp. 129-139 ◽  
Author(s):  
Mehdi Najar ◽  
Hussein Fayyad-Kazan ◽  
Wissam H. Faour ◽  
Bassam Badran ◽  
Fabrice Journe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Immune Response ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Tumor ◽  
Breast Cancer Cells

Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells

Neoplasma ◽  
2011 ◽  
Vol 58 (5) ◽  
pp. 361-370 ◽  
Author(s):  
L. KUCEROVA ◽  
M. KOVACOVICOVA ◽  
S. POLAK ◽  
M. BOHAC ◽  
J. FEDELES ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Human Adipose Tissue

Mortalin antibody-conjugated quantum dot transfer from human mesenchymal stromal cells to breast cancer cells requires cell–cell interaction

2013 ◽  
Vol 319 (18) ◽  
pp. 2770-2780 ◽  
Author(s):  
Mika Pietilä ◽  
Petri Lehenkari ◽  
Paula Kuvaja ◽  
Mika Kaakinen ◽  
Sunil C. Kaul ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantum Dot ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Cell Interaction ◽  
Human Mesenchymal Stromal Cells ◽  
Cell Cell

scholarly journals Gap Junction–Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells

2011 ◽  
Vol 71 (5) ◽  
pp. 1550-1560 ◽  
Author(s):  
Philip K. Lim ◽  
Sarah A. Bliss ◽  
Shyam A. Patel ◽  
Marcelo Taborga ◽  
Meneka A. Dave ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Bone Marrow ◽  
Gap Junction ◽  
Cancer Cells ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Breast Cancer Cells ◽  
Marrow Stromal Cells

scholarly journals Erratum to: Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Svetlana Skolekova ◽  
Miroslava Matuskova ◽  
Martin Bohac ◽  
Lenka Toro ◽  
Erika Durinikova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Antitumor Effect

Interactions of breast cancer cells with the microenvironment of the human bone marrow

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22097-e22097
Author(s):  
T. Kaiser ◽  
G. Klein ◽  
E. Solomayer ◽  
D. Wallwiener ◽  
T. Fehm
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cell Migration ◽  
Cell Adhesion ◽  
Tumor Cell ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Migration Assays

e22097 Background: Bone is one of the most favored sites for metastasis of breast cancer cells (BrCa) resulting in the formation of osteolytic and/or osteoblastic lesions. There is increasing evidence that the bone marrow (BM) microenvironment plays a pivotal role in modulating tumor cell homing to the bone, metastasis and progression. However, the molecular crosstalk between BrCa cells and the cellular and extracellular components of the bone marrow leading to osteotropism still remains a poorly characterized step in the metastatic process. Methods: Cell adhesion and migration assays using the invasive MDA-MB-231 and the noninvasive MCF7 BrCa cell lines were performed to investigate the impact of BM components on cellular functions of tumor cells. Results: Cell-matrix adhesion assays showed a strong and concentration-dependent attachment of BrCa cells to several extracellular matrix components present in the human bone marrow such as fibronectin, different laminin isoforms, collagens type I and IV or tenascin-C. Moreover, the BrCa cells attached avidly to the BM-derived primary osteoblasts, whereas the binding to stromal cells was significantly weaker. Notably, cell-cell adhesion experiments with primary osteoclasts revealed an anti-adhesive effect on tumor cell binding leading to no attachment activity of BrCa cells with the cell surface of primary osteoclasts. The influence of cellular components of the BM on tumor cell migration was analyzed by cell migration assays using conditioned media of osteoblasts, osteoclasts and stromal cells or a modified Transwell chamber technique. The migration assays with invasive MDA-MB-231 cells clearly showed that osteoblasts, but not osteoclasts or stromal cells released factors which led to a faster wound closure, suggesting an enhanced migratory ability of the metastatic tumor cells, whereas the migration of nonmetastatic MCF7 cells was unaffected. Conclusions: These data indicate that the crosstalk with osteoblasts affects both the adhesive and the migratory ability of BrCa cells favoring the bone colonization process. Furthermore, the presented experimental conditions may provide useful tools to study effects of antiresorptive drugs like bisphosphonates to improve therapeutic strategies for treatment metastatic bone disease. No significant financial relationships to disclose.

Osteoprotegerin (OPG) Produced by Bone Marrow Stromal Cells Protects Breast Cancer Cells from TRAIL-Induced Apoptosis

2004 ◽  
Vol 86 (3) ◽  
pp. 271-282 ◽  
Author(s):  
H.L. Neville-Webbe ◽  
N.A. Cross ◽  
C.L. Eaton ◽  
R. Nyambo ◽  
C.A. Evans ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Cells ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Breast Cancer Cells ◽  
Marrow Stromal Cells ◽  
Induced Apoptosis
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