Prediction of failure load using micro-finite element analysis models: Toward in vivo strength assessment

2006 ◽  
Vol 3 (2) ◽  
pp. 221-229 ◽  
Author(s):  
G. Harry van Lenthe ◽  
Ralph Müller
1999 ◽  
Author(s):  
Rebecca Cragun ◽  
Larry L. Howell

Abstract Thermomechanical in-plane microactuators (TIMs) have been designed, modeled, fabricated, and tested. TIMs offer an alternative to arrays of smaller thermal actuators to obtain high output forces. The design is easily modified to obtain the desired output force or deflection for specific applications. The operational principle is based on the symmetrical thermal expansion of variable cross sections of the surface micromachined microdevice. Sixteen configurations of TIMs were fabricated of polysilicon. Finite element analysis models were used to predict the deflection and output force for the actuators. Experimental results were also recorded for all sixteen configurations, including deflections and output forces up to 20 micron and 35 dyne.


2017 ◽  
Vol 103 (1) ◽  
pp. 196-205 ◽  
Author(s):  
Natalie E Cusano ◽  
Mishaela R Rubin ◽  
Barbara C Silva ◽  
Yu-Kwang Donovan Tay ◽  
John M Williams ◽  
...  

Abstract Context High-resolution peripheral quantitative computed tomography (HRpQCT) is a noninvasive imaging technology that can provide insight into skeletal microstructure and strength. In asymptomatic primary hyperparathyroidism (PHPT), HRpQCT imaging has demonstrated both decreased cortical and trabecular indices, consistent with evidence for increased fracture risk. There are limited data regarding changes in HRpQCT parameters postparathyroidectomy. Objective To evaluate changes in skeletal microstructure by HRpQCT in subjects with PHPT after parathyroidectomy. Design We studied 29 subjects with PHPT (21 women, 8 men) with HRpQCT at baseline and 6, 12, 18, and 24 months postparathyroidectomy. Main Outcome Measures Volumetric bone mineral density, microarchitectural indices, and finite element analysis at the distal radius and tibia. Results At both the radius and tibia, there were significant improvements in total, cortical, and trabecular volumetric bone density as early as 6 months postparathyroidectomy (24-month values for total volumetric bone density, radius: +2.8 ± 4%, tibia: +4.4 ± 4%; P < 0.0001 for both), cortical thickness (radius: +1.1 ± 2%, tibia: +2.0 ± 3%; P < 0.01 for both), and trabecular bone volume (radius: +3.8 ± 5%, tibia: +3.2 ± 4%; P < 0.0001 for both). At both sites, by finite element analysis, stiffness and failure load were improved starting at 6 months postparathyroidectomy (24-month values for failure load, radius: +6.2 ± 6%, tibia: +4.8 ± 7%; P < 0.0001 for both). Conclusions These results provide information about skeletal microarchitecture in subjects with PHPT followed through 2 years after parathyroidectomy. Estimated bone strength is improved, consistent with data showing decreased fracture risk postparathyroidectomy.


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