Ageing and blood pressure modulate the relationship between metabolic syndrome and aortic stiffness in never-treated essential hypertensive patients. A comparative study

Abstract Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota. Results In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes. Conclusions Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture. Trial registration: Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726

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Relationship between Plasma Trimethylamine N-Oxide Levels and Renal Dysfunction in Patients with Hypertension

Kidney & Blood Pressure Research ◽

10.1159/000513033 ◽

2021 ◽

pp. 1-12

Author(s):

Jia Zhou ◽

Dingkun Wang ◽

Bingong Li ◽

Xuelian Li ◽

Xingjun Lai ◽

...

Keyword(s):

Blood Pressure ◽

Kidney Disease ◽

Renal Dysfunction ◽

High Performance ◽

Characteristic Curve ◽

Area Under The Curve ◽

Hypertensive Patients ◽

Ckd Stage ◽

Liquid Chromatography Tandem Mass ◽

The Relationship

Introduction: Trimethylamine N-oxide (TMAO) is a metabolite produced by gut bacteria. Although increased TMAO levels have been linked to hypertension (HTN) and chronic kidney disease (CKD) with poor prognosis, no clinical studies have directly addressed the relationship between them. In this study, we investigated the relationship between TMAO and renal dysfunction in hypertensive patients. Methods: We included healthy controls (n = 50), hypertensive patients (n = 46), and hypertensive patients with renal dysfunction (n = 143). Their blood pressure values were taken as the highest measured blood pressure. Renal function was evaluated using the estimated glomerular filtration rate. Plasma TMAO levels were measured using high-performance liquid chromatography tandem mass spectrometry. Results: We found significant differences in plasma TMAO levels among the 3 groups (p < 0.01). The plasma TMAO of patients with HTN was significantly higher than that of healthy people, and the plasma TMAO of patients with HTN complicated by renal dysfunction was significantly higher than either of the other groups. Patients in the highest TMAO quartile were at a higher risk of developing CKD stage 5 than those in the lowest quartile. In the receiver operating characteristic curve, the area under the curve of TMAO combined with β 2-macroglobulin for predicting renal dysfunction in patients with HTN was 0.85 (95% confidence interval 0.80–0.90). Conclusion: An elevated TMAO level reflects higher levels of HTN and more severe renal dysfunction. TMAO, combined with β 2-macroglobulin levels, may assist in diagnosing CKD in hypertensive patients. Plasma TMAO has predictive value for early kidney disease in hypertensive patients.

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Non-fixed combination perindopril+moxonidine for blood pressure control in hypertensive patients with metabolic syndrome

Kardiologiya i serdechno-sosudistaya khirurgiya ◽

10.17116/kardio202114021208 ◽

2021 ◽

Vol 14 (2) ◽

pp. 208

Author(s):

S.V. Nedogoda ◽

E.V. Chumachek ◽

A.A. Ledyaeva ◽

V.V. Tsoma ◽

D.S. Vlasov ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Blood Pressure Control ◽

Fixed Combination ◽

Pressure Control ◽

Hypertensive Patients

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The Relationship Between Objectively Measured Physical Activity, Salivary Cortisol, and the Metabolic Syndrome Score in Girls

Pediatric Exercise Science ◽

10.1123/pes.2013-0109 ◽

2014 ◽

Vol 26 (3) ◽

pp. 221-230 ◽

Cited By ~ 8

Author(s):

Katrina D. DuBose ◽

Andrew J. McKune

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Body Fat ◽

Salivary Cortisol ◽

Sexual Maturity ◽

Vigorous Physical Activity ◽

The Metabolic Syndrome ◽

The Relationship

The relationship between physical activity levels, salivary cortisol, and the metabolic syndrome (MetSyn) score was examined. Twenty-three girls (8.4 ± 0.9 years) had a fasting blood draw, waist circumference and blood pressure measured, and wore an ActiGraph accelerometer for 5 days. Saliva samples were collected to measure cortisol levels. Previously established cut points estimated the minutes spent in moderate, vigorous, and moderate-to-vigorous physical activity. A continuous MetSyn score was created from blood pressure, waist circumference, high-density-lipoprotein (HDL), triglyceride, and glucose values. Correlation analyses examined associations between physical activity, cortisol, the MetSyn score, and its related components. Regression analysis examined the relationship between cortisol, the MetSyn score, and its related components adjusting for physical activity, percent body fat, and sexual maturity. Vigorous physical activity was positively related with 30 min post waking cortisol values. The MetSyn score was not related with cortisol values after controlling for confounders. In contrast, HDL was negatively related with 30 min post waking cortisol. Triglyceride was positively related with 30 min post waking cortisol and area under the curve. The MetSyn score and many of its components were not related to cortisol salivary levels even after adjusting for physical activity, body fat percentage, and sexual maturity.

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The relationship between nocturnal blood pressure drop and body composition indices among hypertensive patients

Journal of Clinical Hypertension ◽

10.1111/jch.13832 ◽

2020 ◽

Vol 22 (4) ◽

pp. 616-622

Author(s):

Selcuk Candan ◽

Ozlem Ozdemir Candan ◽

Turgut Karabag

Keyword(s):

Blood Pressure ◽

Body Composition ◽

Pressure Drop ◽

Hypertensive Patients ◽

Nocturnal Blood Pressure ◽

The Relationship

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Contribution of BKCa channels to local metabolic coronary vasodilation: effects of metabolic syndrome

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00876.2009 ◽

2010 ◽

Vol 298 (3) ◽

pp. H966-H973 ◽

Cited By ~ 33

Author(s):

Léna Borbouse ◽

Gregory M. Dick ◽

Gregory A. Payne ◽

Brittany D. Payne ◽

Mark C. Svendsen ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Heart Rate ◽

Atherogenic Diet ◽

Bkca Channels ◽

Selective Blockade ◽

Before And After ◽

Lactate Uptake ◽

Exercise Induced ◽

The Relationship

This investigation was designed to examine the hypothesis that impaired function of coronary microvascular large-conductance Ca2+-activated K+ (BKCa) channels in metabolic syndrome (MetS) significantly attenuates the balance between myocardial oxygen delivery and metabolism at rest and during exercise-induced increases in myocardial oxygen consumption (MV̇o2). Studies were conducted in conscious, chronically instrumented Ossabaw swine fed a normal maintenance diet (11% kcal from fat) or an excess calorie atherogenic diet (43% kcal from fat, 2% cholesterol, 20% kcal from fructose) that induces many common features of MetS. Data were collected under baseline/resting conditions and during graded treadmill exercise before and after selective blockade of BKCa channels with penitrem A (10 μg/kg iv). We found that the exercise-induced increases in blood pressure were significantly elevated in MetS swine. No differences in baseline cardiac function or heart rate were noted. Induction of MetS produced a parallel downward shift in the relationship between coronary venous Po2 and MV̇o2 ( P < 0.001) that was accompanied by a marked release of lactate (negative lactate uptake) as MV̇o2 was increased with exercise ( P < 0.005). Inhibition of BKCa channels with penitrem A did not significantly affect blood pressure, heart rate, or the relationship between coronary venous Po2 and MV̇o2 in lean or MetS swine. These data indicate that BKCa channels are not required for local metabolic control of coronary blood flow under physiological (lean) or pathophysiological (MetS) conditions. Therefore, diminished function of BKCa channels does not contribute to the impairment of myocardial oxygen-supply demand balance in MetS.

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