Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells

2007 ◽  
Vol 77 (3) ◽  
pp. S30-S40 ◽  
Author(s):  
Yasuhiko Yamamoto ◽  
Hideto Yonekura ◽  
Takuo Watanabe ◽  
Shigeru Sakurai ◽  
Hui Li ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Short Chain ◽  
Chain Aldehyde

scholarly journals Characterization of Mouse Short-chain Aldehyde Reductase (SCALD), an Enzyme Regulated by Sterol Regulatory Element-binding Proteins

2003 ◽  
Vol 278 (34) ◽  
pp. 32380-32389 ◽  
Author(s):  
Anne Kasus-Jacobi ◽  
Jiafu Ou ◽  
Yuriy K. Bashmakov ◽  
John M. Shelton ◽  
James A. Richardson ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Regulatory Element ◽  
Short Chain ◽  
Aldehyde Reductase ◽  
Sterol Regulatory Element ◽  
Chain Aldehyde

A lipid-hydrolysing activity involved in hexenal formation

2000 ◽  
Vol 28 (6) ◽  
pp. 857-860 ◽  
Author(s):  
K. Matsui ◽  
S. Kurishita ◽  
A. Hisamitsu ◽  
T. Kajiwara
Keyword(s):  
Short Chain ◽  
Hydroperoxide Lyase ◽  
Plant Tissues ◽  
Lipolytic Enzyme ◽  
Insect Herbivores ◽  
Time Period ◽  
Genes Encoding ◽  
Acid Hydroperoxide ◽  
Nitrogen Stream ◽  
Chain Aldehyde

Short-chain aldehydes such as (3Z)-hexenal and n-hexanal are formed from lipids through sequential actions of lipid-hydrolysing, lipoxygenase and fatty acid hydroperoxide lyase activities. The aldehydes are formed upon wounding of plant tissues, and are reported to have bactericidal and fungicidal activities. Furthermore, it has been reported that the aldehydes can induce expression of a subset of genes involved in disease resistance and that they are involved in a defence response against insect herbivores. Although several genes encoding lipoxygenases and the lyases have been isolated, and characterized to some extent, only little is known about the enzyme accountable for the lipid-hydrolysing step. In this study, we tried to characterize the lipid-hydrolysing activity involved in the short-chain aldehyde formation in Arabidopsis. When Arabidopsis leaves were homogenized, (3Z)-hexenal was formed rapidly within a few minutes. During this time period, the amount of α-linolenic acid and C16:3 rapidly decreased. Such a rapid increase of the aldehyde was repressed almost completely when the leaves were homogenized under a nitrogen stream, and instead free trienoic acids accumulated. A lipase inhibitor, quinacrine, successfully repressed the hydrolysis. It was revealed that trienoic acids in monogalactosyldiacylglycerol were predominantly hydrolysed during the formation of short-chain aldehydes. Collectively, it is suggested that the lipolytic enzyme involved in the short-chain aldehyde formation is a galactolipid-specific lipase.

scholarly journals Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells

2018 ◽  
Vol 831 ◽  
pp. 52-59 ◽  
Author(s):  
Meng Li ◽  
Betty C.A.M. van Esch ◽  
Gerry T.M. Wagenaar ◽  
Johan Garssen ◽  
Gert Folkerts ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Anti Inflammatory ◽  
Chain Fatty Acids

scholarly journals Acute effects of short-chain alkylglycerols on blood-brain barrier properties of cultured brain endothelial cells

2013 ◽  
Vol 169 (7) ◽  
pp. 1561-1573 ◽  
Author(s):  
P Hülper ◽  
S Veszelka ◽  
F R Walter ◽  
H Wolburg ◽  
P Fallier-Becker ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Brain Barrier ◽  
Barrier Properties ◽  
Short Chain ◽  
Brain Barrier ◽  
Brain Endothelial Cells ◽  
Acute Effects ◽  
Blood Brain

Endotoxin Alteration of the Mucopolysaccharide Blood Vessel Coating in Rats

1974 ◽  
Vol 32 ◽  
pp. 148-149
Author(s):  
D. E. Philpott ◽  
A. Takahashi
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Salivary Gland ◽  
Carotid Artery ◽  
Basement Membrane ◽  
Coronary Vessels ◽  
Ruthenium Red ◽  
E Coli ◽  
Old Rats ◽  
The Brain

Two month, eight month and two year old rats were treated with 10 or 20 mg/kg of E. Coli endotoxin I. P. The eight month old rats proved most resistant to the endotoxin. During fixation the aorta, carotid artery, basil arartery of the brain, coronary vessels of the heart, inner surfaces of the heart chambers, heart and skeletal muscle, lung, liver, kidney, spleen, brain, retina, trachae, intestine, salivary gland, adrenal gland and gingiva were treated with ruthenium red or alcian blue to preserve the mucopolysaccharide (MPS) coating. Five, 8 and 24 hrs of endotoxin treatment produced increasingly marked capillary damage, disappearance of the MPS coating, edema, destruction of endothelial cells and damage to the basement membrane in the liver, kidney and lung.

Sign in / Sign up

Export Citation Format

Share Document