Corrigendum to “The impact of periodontal treatment on healthcare costs in newly diagnosed diabetes patients: Evidence from a German claims database” [Diabetes Res. Clin. Pract. 172 (2021) 108641]

Background: Long-term clinical outcome is less well known in up to presentation persons unknown with diabetes mellitus who present with acute myocardial infarction and elevated glycosylated haemoglobin (HbA1c) levels on admission. We aimed to study the prognostic impact of deranged HbA1c at presentation on long-term mortality in patients not known with diabetes, presenting with acute myocardial infarction. Methods: A single-centre, large, prospective observational study in patients with and without known diabetes admitted to our hospital for ST-segment elevation myocardial infarction (STEMI) and non-STEMI. Newly diagnosed diabetes mellitus was defined as HbA1c of 48 mmol/l or greater and pre-diabetes mellitus was defined as HbA1c between 39 and 47 mmol/l. The primary endpoint was all-cause mortality at short (30 days) and long-term (median 52 months) follow-up. Results: Out of 7900 acute myocardial infarction patients studied, 1314 patients (17%) were known diabetes patients. Of the 6586 patients without known diabetes, 3977 (60%) had no diabetes, 2259 (34%) had pre-diabetes and 350 (5%) had newly diagnosed diabetes based on HbA1c on admission. Both short-term (3.9% vs. 7.4% vs. 6.0%, p<0.001) and long-term mortality (19% vs. 26% vs. 35%, p<0.001) for both pre-diabetes patients as well as newly diagnosed diabetes patients was poor and comparable to known diabetes patients. After multivariate analysis, newly diagnosed diabetes was independently associated with long-term mortality (hazard ratio 1.72, 95% confidence interval 1.27–2.34, P=0.001). Conclusions: In the largest study to date, newly diagnosed or pre-diabetes was present in 33% of acute myocardial infarction patients and was associated with poor long-term clinical outcome. Newly diagnosed diabetes (HbA1c ⩾48 mmol/mol) is an independent predictor of long-term mortality. More attention to early detection of diabetic status and initiation of blood glucose-lowering treatment is necessary.

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A non-clinical randomised controlled trial to assess the impact of pharmaceutical care intervention on satisfaction level of newly diagnosed diabetes mellitus patients in a tertiary care teaching hospital in Nepal

BMC Health Services Research ◽

10.1186/s12913-015-0715-5 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 8

Author(s):

Dinesh Kumar Upadhyay ◽

Mohamed Izham Mohamed Ibrahim ◽

Pranaya Mishra ◽

Vijay M Alurkar

Keyword(s):

Diabetes Mellitus ◽

Controlled Trial ◽

Tertiary Care ◽

Satisfaction Level ◽

Newly Diagnosed ◽

Care Intervention ◽

Randomised Controlled ◽

Diagnosed Diabetes ◽

Newly Diagnosed Diabetes ◽

The Impact

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The impact of newly diagnosed diabetes mellitus on cancer-free survival in patients without colorectal polyps: A secondary analysis of Korean multicenter cancer cohort

Annals of Oncology ◽

10.1093/annonc/mdz421.008 ◽

2019 ◽

Vol 30 ◽

pp. ix32

Author(s):

C. Xiong

Keyword(s):

Diabetes Mellitus ◽

Secondary Analysis ◽

Colorectal Polyps ◽

Newly Diagnosed ◽

Free Survival ◽

Diagnosed Diabetes ◽

Newly Diagnosed Diabetes ◽

The Impact

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The Impact of Glyco-Metabolic Status in Patients Treated for Acute Coronary Syndrome

PRILOZI ◽

10.2478/prilozi-2018-0022 ◽

2018 ◽

Vol 39 (1) ◽

pp. 37-50

Author(s):

Marija Vavlukis ◽

Biljana Zafirovska ◽

Emilija Antova ◽

Bekim Pocesta ◽

Enes Shehu ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Glycemic Control ◽

Morbidity And Mortality ◽

Newly Diagnosed ◽

Stress Hyperglycemia ◽

Coronary Syndrome ◽

Hospital Morbidity ◽

Diagnosed Diabetes ◽

Newly Diagnosed Diabetes ◽

The Impact

Abstract Objective: The aim of the study was to assess the prevalence of newly diagnosed diabetes in patients with acute coronary syndrome and estimate the relationship between stress hyperglycemia, glyco-regulation and newly diagnosed diabetes with hospital morbidity and mortality. Methods: This was an observational study which included all patients hospitalized due to acute coronary syndrome (January 2015 until April 2017) at the University Clinic of Cardiology in Skopje, Macedonia. We analyzed demographic, clinical, biochemical variables and hospital morbidity and mortality. Five investigated groups were compared using a single biochemical parameter glycated hemoglobin (HgbA1c) depending on the presence of known diabetes before the acute event: 0-without DM (HgbA1c <5.6%), 1-newly diagnosed pre-diabetes (HgbA1c 5.6-6.5%), 2-newly diagnosed diabetes (HgbA1c ≥ 6.5%), 3-known well controlled diabetes (HgbA1c <7%) and 4-known un-controlled diabetes (HgbA1c ≥7%). Results: 860 patients were analyzed. Impaired glucose metabolism was confirmed in 35% of patients, 9% of which were with newly diagnosed diabetes. Stress hyperglycemia was reported in 27.3% (3.6% were without diabetes). The highest values of stress hyperglycemia were reported in newly diagnosed and known un-controlled diabetes. In-hospital morbidity and mortality were 15% and 5% accordingly and the rate was highest in patients with newly diagnosed and known, but un-controlled diabetes. HgbA1c, stress hyperglycemia, and poor glycemic control have emerged as significant independent predictors of hospital morbidity and mortality in patients with acute coronary syndrome. Conclusion: High prevalence of newly diagnosed diabetes was observed in patients with acute coronary syndrome. Stress hyperglycemia and failure to achieve glycemic control are independent predictors of hospital morbidity and mortality.

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