P5 - Use of the HμREL® human hepatocyte co-culture model to determine intrinsic clearance and elucidate metabolic pathways of stable compounds

2020 ◽  
Vol 35 (1) ◽  
pp. S24
Author(s):  
Philip Butler ◽  
Jo Wilcock ◽  
Lara Ward ◽  
Katie Paine ◽  
Marks Vahmjanins ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Intrinsic Clearance ◽  
Human Hepatocyte ◽  
Culture Model

scholarly journals Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery

2018 ◽  
Vol 46 (8) ◽  
pp. 1169-1178 ◽  
Author(s):  
Paul Lancett ◽  
Beth Williamson ◽  
Patrick Barton ◽  
Robert J. Riley
Keyword(s):  
Drug Discovery ◽  
Intrinsic Clearance ◽  
Human Hepatocyte

Development of a primary human hepatocyte spheroid culture model for drug metabolism and disposition studies

2018 ◽  
Vol 33 (1) ◽  
pp. S69
Author(s):  
Kajsa P. Kanebratt ◽  
Annika Janefeldt ◽  
Alexandra Peric ◽  
Julia Jonsson ◽  
Linnea Johansson ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Human Hepatocyte ◽  
Spheroid Culture ◽  
Hepatocyte Spheroid ◽  
Primary Human Hepatocyte ◽  
Culture Model

scholarly journals A 3D Cell Culture Model Identifies Wnt/ β ‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration

2020 ◽  
Vol 7 (15) ◽  
pp. 2000248 ◽  
Author(s):  
Nuria Oliva‐Vilarnau ◽  
Sabine U. Vorrink ◽  
Magnus Ingelman‐Sundberg ◽  
Volker M. Lauschke
Keyword(s):  
Cell Culture ◽  
3D Cell Culture ◽  
Human Hepatocyte ◽  
Cell Culture Model ◽  
Critical Step ◽  
Hepatocyte Regeneration ◽  
Culture Model

Identification of metabolic pathways of pindolol and fluperlapine in adult human hepatocyte cultures

Xenobiotica ◽  
1988 ◽  
Vol 18 (2) ◽  
pp. 131-139 ◽  
Author(s):  
André Guillouzo ◽  
Jean-Marc Bégué ◽  
Gérard Maurer ◽  
Patrick Koch
Keyword(s):  
Metabolic Pathways ◽  
Human Hepatocyte ◽  
Adult Human ◽  
Hepatocyte Cultures
Sign in / Sign up

Export Citation Format

Share Document