scholarly journals Neighbourhood structural characteristics and crack cocaine use: Exploring the impact of perceived neighbourhood disorder on use among African Americans

2014 ◽  
Vol 25 (3) ◽  
pp. 616-623 ◽  
Author(s):  
Claire E. Sterk ◽  
Kirk W. Elifson ◽  
Lara DePadilla
Keyword(s):  
African Americans ◽  
Crack Cocaine ◽  
Structural Characteristics ◽  
Cocaine Use ◽  
The Impact ◽  
Neighbourhood Disorder

scholarly journals A mathematical model of the impact of crack-cocaine use on the prevalence of HIV/AIDS among drug users

1998 ◽  
Vol 28 (3) ◽  
pp. 21-29 ◽  
Author(s):  
M.N. Burattini ◽  
E. Massad ◽  
F.A.B. Coutinho ◽  
R.S. Azevedo-Neto ◽  
R.X. Menezes ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Drug Users ◽  
Crack Cocaine ◽  
Cocaine Use ◽  
The Impact ◽  
Hiv Aids

The Impact of Crack Enforcement on Police Budgets

1998 ◽  
Vol 28 (3) ◽  
pp. 701-724 ◽  
Author(s):  
Mary Bumgarner ◽  
David L. Sjoquist
Keyword(s):  
Urban Areas ◽  
Crack Cocaine ◽  
Time Series Data ◽  
The United States ◽  
Behavioral Changes ◽  
Series Data ◽  
Data Set ◽  
Cocaine Use ◽  
Crack Use ◽  
The Impact

During the 1980s, many urban areas in the United States experienced a widespread expansion in the use of drugs in general and crack cocaine in particular. This expansion of crack use is thought to have resulted in various behavioral changes, e.g., an increase in crime and an increase in expenditures to reduce drug use. This paper examines how local police spending responded to the spread of crack cocaine. We use a pooled cross-section, time series data set consisting of 18 cities over the period 1982 through 1989 to estimate the impact of crack cocaine use on police spending, and find that police expenditures increased significantly as crack cocaine use rose.

USSC Staff Analysis of the Impact of the Crack Cocaine Amendment if Made Retroactive

2007 ◽  
Vol 20 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Glenn Schmitt ◽  
Lou Reedt ◽  
Kenneth Cohen
Keyword(s):  
Crack Cocaine ◽  
The Impact

Crack and Criminal Justice in Canton, Ohio, 1987–1999: “The Drug Problem has Created a Monster”

2021 ◽  
Vol 33 (2) ◽  
pp. 143-182
Author(s):  
WILL COOLEY
Keyword(s):  
Criminal Justice ◽  
Law Enforcement ◽  
African Americans ◽  
Justice System ◽  
Crack Cocaine ◽  
Mass Incarceration ◽  
War On Drugs ◽  
Drug Problem ◽  
Industrial City ◽  
The City

AbstractThe rise of crack cocaine in the late 1980s propelled the war on drugs. The experience of Canton, Ohio, shows how the response to crack solidified mass incarceration. A declining industrial city of 84,000 people in northeast Ohio with deep-seated racial divides, it was overwhelmed by aggressive, enterprising crack dealers from outside the city. In response, politicians and residents united behind the strategy of incessant arrests and drastic prison sentences. The law-enforcement offensive worsened conditions while pursuing African Americans at blatantly disproportionate rates, but few people engaged in reframing the drug problem. Instead, a punitive citizenry positioned punishment as the principal remedy. The emergency foreclosed on more comprehensive assessments of the city’s tribulations, while the criminal justice system emerged as the paramount institution.

scholarly journals Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Zhihui Dou ◽  
Dapeng Zhao ◽  
Xiaohua Chen ◽  
Caipeng Xu ◽  
Xiaodong Jin ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Structural Characteristics ◽  
Therapy Resistance ◽  
Regulatory Elements ◽  
Aberrant Splicing ◽  
Clinical Role ◽  
Splicing Isoforms ◽  
The Impact ◽  
Splicing Patterns

AbstractBcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splicing is implicated in genesis and development of multiple human diseases, especially cancers. Exploring the mechanism of Bcl-x splicing and regulation has provided insight into the development of drugs that could contribute to sensitivity of cancer cells to death. On this basis, we review the multiple splicing patterns and structural characteristics of Bcl-x. Additionally, we outline the cis-regulatory elements, trans-acting factors as well as epigenetic modifications involved in the splicing regulation of Bcl-x. Furthermore, this review highlights aberrant splicing of Bcl-x involved in apoptosis evade, autophagy, metastasis, and therapy resistance of various cancer cells. Last, emphasis is given to the clinical role of targeting Bcl-x splicing correction in human cancer based on the splice-switching oligonucleotides, small molecular modulators and BH3 mimetics. Thus, it is highlighting significance of aberrant splicing isoforms of Bcl-x as targets for cancer therapy.

scholarly journals 545. The Impact of COVID-19 on African Americans’ Health Attitudes and Information Seeking Behavior

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S338-S339
Author(s):  
Katherine Kricorian ◽  
Ozlem Equils ◽  
Karin Kricorian ◽  
Brianna Rochebrun
Keyword(s):  
African Americans ◽  
Information Seeking ◽  
Disease Incidence ◽  
Family Members ◽  
National Sample ◽  
Health Attitudes ◽  
Health News ◽  
Before And After ◽  
Science And Government ◽  
The Impact

Abstract Background African-Americans suffer a disproportionate impact from COVID-19, comprising about 24% of deaths while representing 13% of the US population. We conducted a study to understand COVID-19’s impact on African-Americans’ health attitudes. Methods In April 2020, we surveyed online a national sample of US adults on their health attitudes and behaviors before and after the COVID-19 outbreak. Comparisons were analyzed using chi-squared tests. Results A total of 2,544 individuals completed the survey: 473 African-Americans, 282 Hispanics and 1,799 Caucasians responded. The mean ages of each group were 41.4 ± 11 years, 38.0 ± 11 years and 45.7 ± 13 years, respectively. Before COVID-19, African-Americans were least likely to report they had trust in science (53% vs. 68% for Hispanics and 77% for Caucasians; p< .01) and government (16% vs. 27% and 28%; p< .01). After COVID-19, the percentage of African-Americans who had trust in science and government fell further to 44% (p< .01) and 9% (p< .01), respectively, and remained significantly lower than the other two groups. Twice as many African-Americans vs. Caucasians stopped following science and health news after COVID-19 (9% vs. 4%, p< .01). The percentage of African-Americans who reported anxiety about their health rose from 30% pre-COVID to 53% after the outbreak (p< .01), and the percentage who reported anxiety about their family members’ health rose from 35% to 61% (p< .01). Only 25% of African-Americans surveyed agreed that if they contracted COVID-19, they were confident they would get the healthcare needed. Conclusion After COVID-19, African-Americans’ trust in science and government fell and a meaningful percentage stopped following science and health news, possibly reducing access to important health information. The percentage of African-Americans reporting anxiety about the future, about their health and about their family members’ health all increased significantly after COVID-19. Only a minority of African-Americans agreed they would get the needed healthcare if they contracted COVID-19. These findings have implications for the mental health and behavioral impacts of COVID-19 on African-Americans and for the development of health communications to high-disease-incidence populations. Disclosures All Authors: No reported disclosures

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