Transthyretin levels are not related to Apgar score in low birth weight and very low birth weight infants

Objective The study aimed to determine the outcome of babies born to women ≥40 years in a Jamaican birth cohort. Patients and Methods Maternal demographic data and neonatal data for women ≥40 years who delivered live singleton babies and their younger counterparts aged 20 30 years were extracted from the JA KIDS birth cohort dataset. Outcome measures were preterm birth, low birth weight, very low birth weight, extremely low birth weight, macrosomia, a low 5-minute Apgar score <7, admission to the neonatal unit, and neonatal death. Descriptive analyses were performed; statistical significance was taken at the level p <0.05. Results A total of 5,424 women and their babies were entered into the study, 5,099 (94%) women were aged 20 to 30 years (mean age ± standard deviation [SD]: 24.5 ± 3.2 years) and 325 (6%) were aged ≥40 years (mean age ± SD: 41.5 ± 1.6 years). A greater percentage of preterm babies (18%) were born to women ≥40 years than to their younger counterparts (14%; p = 0.04). There was no difference in the proportion of low birth weight infants, very low birth weight infants, or extremely low birth weight infants born between the two groups (p > 0.05). There was also no significant difference in the proportion of babies who were macrosomic and in those who had a low 5-minute Apgar score <7. There were 866 (16%) neonatal admissions, 67/325 (21%) of these babies were born to women aged ≥40 years and 799/5,099 (16%) were born to their younger counterparts (p = 0.01). The commonest reason for admission was prematurity. While 60 babies died, there was no significant difference between both groups with 56 (1%) born to women 20 to 30 years and 4 (1%) born to women ≥40 years (p = 0.48). Conclusion Adverse outcomes noted for babies born to women ≥40 years were prematurity and the need for neonatal admission. However, no excess mortality was recorded. Key Points

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Variations of Apgar score of very low birth weight infants in different neonatal intensive care units

Acta Paediatrica ◽

10.1111/j.1651-2227.2009.01347.x ◽

2009 ◽

Vol 98 (9) ◽

pp. 1433-1436 ◽

Cited By ~ 17

Author(s):

Mario Rüdiger ◽

Helmut Küster ◽

Egbert Herting ◽

Angelika Berger ◽

Christoph Müller ◽

...

Keyword(s):

Intensive Care ◽

Birth Weight ◽

Low Birth Weight ◽

Intensive Care Units ◽

Apgar Score ◽

Neonatal Intensive Care ◽

Very Low Birth Weight ◽

Neonatal Intensive Care Units ◽

Low Birth Weight Infants

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PREDICTOR VARIABLES OF NEONATAL MORTALITY IN VERY-LOW-BIRTH-WEIGHT INFANTS

International Journal of Advanced Research ◽

10.21474/ijar01/12997 ◽

2021 ◽

Vol 9 (06) ◽

pp. 163-171

Author(s):

Cristina Amaral Calixto ◽

◽

Nathalia Macedo Marteletto ◽

Priscila da Silva Azevedo Leite ◽

Paulo Sergio Leite ◽

...

Keyword(s):

Logistic Regression ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Apgar Score ◽

Maternal Age ◽

Very Low Birth Weight ◽

Low Birth Weight Infants ◽

Kaplan Meier ◽

Type Of Delivery

The aim of this study is to investigate the mortality profile in very-low-birth-weight infants, as well as model the association of some variables with neonatal mortality, in order to detect possible preventable causes of death. This retrospective cross-sectional study included a total of 109 Very-Low-Weight-Infants admitted to a Neonatal Intensive Care Unit in a municipality in Minas Gerais, Brazil, between January 2012 and December 2016. The neonates were divided into two groups: death and non-death. Frequency distributions were constructed for the variables maternal age, sex, birth weight, gestational age, type of delivery, asphyxia (Apgar at five minutes), administration of antenatal corticosteroids, hypothermia, twinning, and amniotic membrane rupture. The survival curve was plotted using the Kaplan-Meier non-parametric estimator, and theassociation between death and the observed explanatory variables was modeled via Logistic Regression. In the survivor group, most infants exhibited normothermia and weight â‰¥1,000g. As for the death group, weight below 1,000g and hypothermic infants were predominant. In both groups, maternal age between 18 and 35 years prevailed, as well as the male sex, gestational age of 224 days, cesarean delivery, and fifth minute Apgar scores â‰¥7. The survival rate, estimated using the Kaplan-Meier method, showed a decrease from 1.0 to 0.55 at the beginning of the observation period. The adjusted logistic regression model included fetal weight and the fifth minute Apgar score. No significant relationship was found between death and the variables type of delivery, hypothermia, and antenatal corticosteroid use.Logistic regression indicated a high probability of death associated with birth weight and the Apgar score at five minutes. The low association with the other variables may be related to the good quality of prenatal, intrapartum, and postpartum care provided in the region and the analyzed hospital.

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