Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

2011 ◽  
Vol 47 (3) ◽  
pp. 420-427 ◽  
Author(s):  
Daniele Campa ◽  
Anika Hüsing ◽  
Jenny Chang-Claude ◽  
Lucie Dostal ◽  
Heiner Boeing ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Genetic Variability ◽  
Cancer Risk ◽  
Fatty Acid Synthase ◽  
Prostate Cancer Risk ◽  
Prospective Investigation

scholarly journals Genetic Variability of the mTOR Pathway and Prostate Cancer Risk in the European Prospective Investigation on Cancer (EPIC)

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e16914 ◽  
Author(s):  
Daniele Campa ◽  
Anika Hüsing ◽  
Angelika Stein ◽  
Lucie Dostal ◽  
Heiner Boeing ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Genetic Variability ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Mtor Pathway ◽  
Prospective Investigation

scholarly journals Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival

2010 ◽  
Vol 28 (25) ◽  
pp. 3958-3964 ◽  
Author(s):  
Paul L. Nguyen ◽  
Jing Ma ◽  
Jorge E. Chavarro ◽  
Matthew L. Freedman ◽  
Rosina Lis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Fatty Acid ◽  
Body Mass ◽  
Fatty Acid Synthase ◽  
Prostate Cancer Risk ◽  
De Novo Lipogenesis ◽  
Variant Allele ◽  
Specific Mortality ◽  
Tumor Expression

Purpose Fatty acid synthase (FASN) regulates de novo lipogenesis, body weight, and tumor growth. We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI). Methods In a prospective nested case-control study of 1,331 white patients with PCa and 1,267 age-matched controls, we examined associations of five common SNPs within FASN (and 5 kb upstream/downstream, R2 > 0.8) with PCa incidence and, among patients, PCa-specific death and tested for an interaction with BMI. Survival analyses were repeated for tumor FASN expression (n = 909). Results Four of the five SNPs were associated with lethal PCa. SNP rs1127678 was significantly related to higher BMI and interacted with BMI for both PCa risk (Pinteraction = .004) and PCa mortality (Pinteraction = .056). Among overweight men (BMI ≥ 25 kg/m2), but not leaner men, the homozygous variant allele carried a relative risk of advanced PCa of 2.49 (95% CI, 1.00 to 6.23) compared with lean men with the wild type. Overweight patients carrying the variant allele had a 2.04 (95% CI, 1.31 to 3.17) times higher risk of PCa mortality. Similarly, overweight patients with elevated tumor FASN expression had a 2.73 (95% CI, 1.05 to 7.08) times higher risk of lethal PCa (Pinteraction = .02). Conclusion FASN germline polymorphisms were significantly associated with risk of lethal PCa. Significant interactions of BMI with FASN polymorphisms and FASN tumor expression suggest FASN as a potential link between obesity and poor PCa outcome and raise the possibility that FASN inhibition could reduce PCa-specific mortality, particularly in overweight men.

scholarly journals Blood fatty acid patterns are associated with prostate cancer risk in a prospective nested case–control study

2016 ◽  
Vol 27 (9) ◽  
pp. 1153-1161 ◽  
Author(s):  
Meng Yang ◽  
Azalea Ayuningtyas ◽  
Stacey A. Kenfield ◽  
Howard D. Sesso ◽  
Hannia Campos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Cancer Risk ◽  
Case Control Study ◽  
Prostate Cancer Risk ◽  
Case Control ◽  
Fatty Acid Patterns ◽  
Nested Case Control ◽  
Control Study

scholarly journals Circulating Concentrations of Folate and Vitamin B12 in Relation to Prostate Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition Study

2008 ◽  
Vol 17 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Mattias Johansson ◽  
Paul N. Appleby ◽  
Naomi E. Allen ◽  
Ruth C. Travis ◽  
Andrew W. Roddam ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Vitamin B12 ◽  
Prostate Cancer Risk ◽  
Nutrition Study ◽  
Folate And Vitamin B12 ◽  
Prospective Investigation

scholarly journals A Prospective Study of Polyunsaturated Fatty Acid Levels in Blood and Prostate Cancer Risk

2007 ◽  
Vol 16 (7) ◽  
pp. 1364-1370 ◽  
Author(s):  
J. E. Chavarro ◽  
M. J. Stampfer ◽  
H. Li ◽  
H. Campos ◽  
T. Kurth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Cancer Risk ◽  
Prospective Study ◽  
Polyunsaturated Fatty Acid ◽  
Prostate Cancer Risk ◽  
A Prospective Study

scholarly journals One-Carbon Metabolism and Prostate Cancer Risk: Prospective Investigation of Seven Circulating B Vitamins and Metabolites

2009 ◽  
Vol 18 (5) ◽  
pp. 1538-1543 ◽  
Author(s):  
Mattias Johansson ◽  
Bethany Van Guelpen ◽  
Stein Emil Vollset ◽  
Johan Hultdin ◽  
Anders Bergh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Prostate Cancer Risk ◽  
B Vitamins ◽  
One Carbon Metabolism ◽  
Prospective Investigation

scholarly journals Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)

2008 ◽  
Vol 88 (6) ◽  
pp. 1567-1575 ◽  
Author(s):  
Naomi E Allen ◽  
Paul N Appleby ◽  
Andrew W Roddam ◽  
Anne Tjønneland ◽  
Nina Føns Johnsen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Selenium Concentration ◽  
Plasma Selenium ◽  
Prospective Investigation ◽  
Plasma Selenium Concentration
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