Omental fat in ovarian cancer induces lymphangiogenesis – The role of an adipose-rich microenvironment in tumor progression and metastatic dissemination

2019 ◽  
Vol 110 ◽  
pp. S6
Author(s):  
V.F. Starrach ◽  
B. Lenoir ◽  
D. Ferber ◽  
M. Suarez-Carmona ◽  
S. Schott ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Progression ◽  
Metastatic Dissemination ◽  
Omental Fat

scholarly journals New Actors Driving the Epithelial–Mesenchymal Transition in Cancer: The Role of Leptin

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1676
Author(s):  
Monserrat Olea-Flores ◽  
Juan C. Juárez-Cruz ◽  
Miriam D. Zuñiga-Eulogio ◽  
Erika Acosta ◽  
Eduardo García-Rodríguez ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Progression ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Epithelial Cancers ◽  
Patients With Cancer

Leptin is a hormone secreted mainly by adipocytes; physiologically, it participates in the control of appetite and energy expenditure. However, it has also been linked to tumor progression in different epithelial cancers. In this review, we describe the effect of leptin on epithelial–mesenchymal transition (EMT) markers in different study models, including in vitro, in vivo, and patient studies and in various types of cancer, including breast, prostate, lung, and ovarian cancer. The different studies report that leptin promotes the expression of mesenchymal markers and a decrease in epithelial markers, in addition to promoting EMT-related processes such as cell migration and invasion and poor prognosis in patients with cancer. Finally, we report that leptin has the greatest biological relevance in EMT and tumor progression in breast, lung, prostate, esophageal, and ovarian cancer. This relationship could be due to the key role played by the enriched tumor microenvironment in adipose tissue. Together, these findings demonstrate that leptin is a key biomolecule that drives EMT and metastasis in cancer.

scholarly journals Tumor progression and metastatic dissemination in ovarian cancer after dose-dense or conventional paclitaxel and cisplatin plus bevacizumab

2018 ◽  
Vol 143 (9) ◽  
pp. 2187-2199 ◽  
Author(s):  
Francesca Bizzaro ◽  
Francesca Falcetta ◽  
Elisa D’Agostini ◽  
Alessandra Decio ◽  
Lucia Minoli ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Progression ◽  
Metastatic Dissemination ◽  
Dose Dense

The current role of gemcitabine in ovarian cancer

2001 ◽  
Vol 28 (2D) ◽  
pp. 18-24
Author(s):  
Robert F. Ozols
Keyword(s):  
Ovarian Cancer ◽  
Current Role

ROLE OF LIPID PROFILE IN OVARIAN CARCINOMA PATIENTS

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Manisha ◽  
Dr. Ruchi Jindal
Keyword(s):  
Ovarian Cancer ◽  
Lipid Profile ◽  
Cancer Patients ◽  
Ovarian Tumor ◽  
Ovarian Cancer Risk ◽  
Low Level ◽  
Medical College ◽  
Group I ◽  
History Of

Background: The term "ovarian cancer" includes several different types of cancer that  arise from cells of the ovary, most commonly, tumors arise from the epithelium or lining cells of the ovary.  Ovarian cancer risk is positively associated with higher consumption of dietary cholesterol and eggs, and inversely associated with a higher intake of vegetables. High consumption of fats may increase circulating estrogen levels, thus increasing the possibility of cell damage and proliferation that is responsible for cancerous growth. Material & Methods: The present study was conducted at Geetanjali Medical College and Hospital, Udaipur (Rajasthan). Total  100 cases (females) attending the obstetrics and gynecology department for some gynecological and other problem  were selected for this study between the age of 40-60 years, who were attending cancer centre at GEETANJALI MEDICAL COLLEGE AND  HOSPITAL, Udaipur (Rajasthan).                GROUP I: - It consisted of healthy females control subjects (n=50) .By routine examination and tests, we ensured that all the subjects were healthy and there were no signs and symptoms or history of ovarian tumor and diseases GROUP II: - It consisted of ovarian cancer females subjects (n=50) with a history of ovarian tumor. Results:   Higher level of cholesterol, LDL, VLDL and low level of HDL are found in ovarian cancer patients. Conclusion: The present study we highlights the importance and role of serum lipid profile in diagnosis, prognosis and recurrence of the disease. The study shows that serum level of cholesterol, LDL, VLDL was elevated in  patients of ovarian cancer while low level of HDL are found in ovarian cancer patients. Key words: lipid profile, ovarian cancer.

The role of peritoneal carcinomatosis index in the operative treatment of ovarian cancer

2018 ◽  
Vol 16 (2) ◽  
pp. 82-88
Author(s):  
Włodzimierz Sawicki ◽  
◽  
Nabil Abdalla ◽  
Krzysztof Cendrowski ◽  
◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Peritoneal Carcinomatosis ◽  
Operative Treatment ◽  
Peritoneal Carcinomatosis Index

ROLE OF ULTRASOUND IN THE DETECTION OF RECURRENT OVARIAN CANCER

2020 ◽  
Vol 6 (1) ◽  
pp. 23-31
Author(s):  
M. Alisherova ◽  
◽  
M. Ismailova
Keyword(s):  
Ovarian Cancer ◽  
Surgical Treatment ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Recurrent Ovarian Cancer ◽  
Primary Diagnosis ◽  
Female Reproductive System

Currently, there are no standard approaches to monitoring patients with ovarian cancer (OC). While the role of ultrasound (US) has been identified in the primary diagnosis of OS, it is still controversial during the subsequent surgical treatment of OC. In world statistics, ovarian cancer is consistently among the four main localizations of malignant tumors of the female reproductive system, along with tumors of the breast, body and cervix.

THE ROLE OF ALLELES OF IL23R GENE IN THE PATHOGENESIS OF OVARIAN CANCER

2018 ◽  
Vol 4 (3) ◽  
pp. 94-98
Author(s):  
E.T. Mingajeva ◽  
◽  
D.S. Prokofyeva ◽  
A.Kh. Nurgalieva ◽  
D.D. Sakaeva ◽  
...  
Keyword(s):  
Ovarian Cancer
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