ROLE OF ULTRASOUND IN THE DETECTION OF RECURRENT OVARIAN CANCER

2020 ◽  
Vol 6 (1) ◽  
pp. 23-31
Author(s):  
M. Alisherova ◽  
◽  
M. Ismailova
Keyword(s):  
Ovarian Cancer ◽  
Surgical Treatment ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Recurrent Ovarian Cancer ◽  
Primary Diagnosis ◽  
Female Reproductive System

Currently, there are no standard approaches to monitoring patients with ovarian cancer (OC). While the role of ultrasound (US) has been identified in the primary diagnosis of OS, it is still controversial during the subsequent surgical treatment of OC. In world statistics, ovarian cancer is consistently among the four main localizations of malignant tumors of the female reproductive system, along with tumors of the breast, body and cervix.

EPIDEMIOLOGICAL ASPECTS OF OVARIAN CANCER IN THE STRUCTURE OF PRIMARY MULTIPLE MALIGNANT TUMORS OF THE FEMALE REPRODUCTIVE SYSTEM (ON THE EXAMPLE OF THE CHELYABINSK REGION)

2018 ◽  
Vol 64 (6) ◽  
pp. 739-744
Author(s):  
Svetlana Bekhtereva ◽  
Yevgeniy Imyanitov ◽  
Andrey Vazhenin ◽  
Alla Domozhirova ◽  
Irina Aksenova ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Female Reproductive System ◽  
Primary And Secondary Prevention ◽  
Cumulative Survival ◽  
Clinical Center ◽  
Number Of Patients ◽  
Prevention Of Cancer ◽  
Chelyabinsk Region

The problem of primary multiplicity of malignant tumors remains relevant in oncology due to the growing number of patients with polyneoplasia, especially for tumors of the female reproductive system. The analysis of the frequency and combinations of polyneoplasias of the reproductive system in women on the example of primary multiple ovarian cancer according to the data of the Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine for 15 years. The calculated indicators of the adjusted cumulative survival of patients with polyneoplasia and solitary ovarian cancer were calculated. The data obtained can be used in clinical practice, as the primary and secondary prevention of cancer in women.

scholarly journals Simultaneous Bariatric Surgeries in Females with Neoplasm of the Reproductive System and Morbid Obesity

2021 ◽  
Vol 14 (1) ◽  
pp. 42-46
Author(s):  
V. Sergeevich Samoilov ◽  
Vadim Viktorovich Popov ◽  
Ivan Petrovich Moshurov ◽  
Alexander Nikolayevich Redkin
Keyword(s):  
Morbid Obesity ◽  
Surgical Treatment ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Pain Syndrome ◽  
Female Reproductive System ◽  
Fundamental Possibility ◽  
Simultaneous Operations ◽  
First Results ◽  
Perioperative Safety

Introduction. The frequency of occurrence of morbid obesity and neoplasms of the female reproductive system is very high and these conditions aggravate each other. Therefore, it is relevant to simultaneously perform laparoscopic bariatric operations and radical interventions for benign and malignant tumors of the female reproductive system in such cases. The experience of such simultaneous interventions is still small and in the available literature is limited to the description of single cases. The primary issues are the fundamental possibility of combining the two stages in one operation, the technical aspects of such interventions, and the assessment of perioperative safety and immediate results.The aim of the study was to create a technique of simultaneous surgical treatment of the pelvic organs neoplasms and morbid obesity in females, to assess the perioperative safety and immediate results of such simultaneous operations.Methods. The authors present their experience and the first results of simultaneous laparoscopic sleeve gastrectomy and hysterectomies in 9 women with malignant and benign neoplasms of female genitals, suffering from morbid obesity. A method of simultaneous combined surgical treatment of neoplasms of female genitals and morbid obesity has been developed and described.Results. The proposed technique allowed performing two interventions during one procedure in a minimum time, technically in the simplest way without additional complications and risks. The duration of simultaneous operations averaged 162.7 21.8 min., the average blood loss was 247.6 31.0 ml, the pain syndrome on the first day was moderately expressed, no serious complications were observed.Conclusions. The results obtained demonstrated that the morbidity and perioperative safety of simultaneous operations are comparable to those with separate performance of such operations with certain benefits.

scholarly journals Species Comparison of the Role of p38 MAP Kinase in the Female Reproductive System

2009 ◽  
Vol 22 (2) ◽  
pp. 109-124 ◽  
Author(s):  
Zaher A. Radi ◽  
Rosemary A. Marusak ◽  
Dale L. Morris
Keyword(s):  
Map Kinase ◽  
Reproductive System ◽  
P38 Map Kinase ◽  
Female Reproductive System ◽  
Species Comparison

scholarly journals Bitter Taste Receptors Expression in Human Granulosa and Cumulus Cells: New Perspectives in Female Fertility

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3127
Author(s):  
Bianca Semplici ◽  
Francesca Paola Luongo ◽  
Sofia Passaponti ◽  
Claudia Landi ◽  
Laura Governini ◽  
...  
Keyword(s):  
Reproductive System ◽  
Bitter Taste ◽  
Receptor Activation ◽  
Female Fertility ◽  
Human Reproduction ◽  
Receptor Subtype ◽  
Taste Receptors ◽  
Female Reproductive System ◽  
Bitter Taste Receptors

Bitter taste receptors (TAS2RS) expression is not restricted to the oral cavity and the presence of these receptors in the male reproductive system and sperm provides insights into their possible role in human reproduction. To elucidate the potential role of TAS2Rs in the female reproductive system, we investigated the expression and localization of bitter taste receptors and the components of signal transduction cascade involved in the pathway of taste receptors in somatic follicular cells obtained from women undergoing assisted reproductive techniques. We found that TAS2R genes are expressed in both cumulus (CCs) and granulosa (GCs) cells, with TAS2R14 being the most highly expressed bitter receptor subtype. Interestingly, a slight increase in the expression of TAS2R14 and TAS2R43 was shown in both GCs and CCs in young women (p < 0.05), while a negative correlation may be established between the number of oocytes collected at the pickup and the expression of TAS2R43. Regarding α-gustducin and α-transducin, two Gα subunits expressed in the taste buds on the tongue, we provide evidence for their expression in CCs and GCs, with α-gustducin showing two additional isoforms in GCs. Finally, we shed light on the possible downstream transduction pathway initiated by taste receptor activation in the female reproductive system. Our study, showing for the first time the expression of taste receptors in the somatic ovarian follicle cells, significantly extends the current knowledge of the biological role of TAS2Rs for human female fertility.

scholarly journals Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

2017 ◽  
Vol 66 (5) ◽  
pp. 46-55 ◽  
Author(s):  
Pavel P. Yakovlev
Keyword(s):  
Reproductive System ◽  
Oocyte Quality ◽  
Aromatase Activity ◽  
Female Reproductive System ◽  
Vitro Fertilization ◽  
P450 Enzyme ◽  
Follicular Response ◽  
P450 Activity

The Aim of the study was to assess modern considerations about the role of aromatase P450 enzyme in female reproductive system and the effect of its activity on the protocols of in vitro fertilization (IVF). Materials: foreign and Russian literature data from 1978 to 2016. Methods:review and synthesis of publications has been performed. Conclusions: Ovarian aromatase is the key steroidogenesis enzyme of the female reproductive system. Its activity depends on many factors, both of intraovarian and extragonadal origin. The ovarian follicular response and oocyte quality in IVF may depend on aromatase activity.

scholarly journals mRNAsi Index-based Integrative Analysis for the Identification of New Prognostic Models for Ovarian Cancer

2020 ◽  
Author(s):  
Xue Pan ◽  
Xiaoxin Ma
Keyword(s):  
Ovarian Cancer ◽  
Clinical Characteristics ◽  
Malignant Tumors ◽  
Lymphatic Invasion ◽  
Prognostic Models ◽  
Overall Survival Rate ◽  
Female Reproductive System ◽  
Competing Endogenous Rna ◽  
Competing Endogenous Rna Network ◽  
Grade 3

Abstract Ovarian cancer (OC) has the highest mortality rate among all female reproductive system malignant tumors worldwide. In this study, we aimed to investigate OC from several perspectives by using machine learning. Our results showed that the mRNA expression-stemness index (mRNAsi) is closely related to clinical characteristics of OC patients, as OC patients with venous or lymphatic invasion had higher mRNAsi score compared to patients with no invasion. Furhter grade 3/4 patient group had higher mRNAsi scores compared to the grade1/2 group. We also found that mRNAsi is closely related to immune infiltration in OC. We also built a competing endogenous RNA network, which contained 4 miRNAs, 5 lncRNAs, and 1 mRNA, by using Cytoscape based on the differentially expressed genes of the high- and low-mRNAsi groups. Through Lassio regression, we also established a model including 7 lncRNAs and 2miRNAs, which could effectively categorize OC patients into two groups based on the median risk score. We then developed a nomogram model which could effectively forecast the overall survival rate of OC for 1-, 3-, and 5-year period. The models assessed in this study showed potential for clinical application in treatment decisions for OC.

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