Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest

2014 ◽  
Vol 83 ◽  
pp. 155-166 ◽  
Author(s):  
Mohamed Fares ◽  
Sahar Mahmoud Abou-Seri ◽  
Hatem A. Abdel-Aziz ◽  
Safinaz E.-S. Abbas ◽  
Mohieldin Magdy Youssef ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Pyrimidine Derivatives ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 418 ◽  
Author(s):  
Thangaraj ◽  
Balasubramanian ◽  
Park ◽  
Natesan ◽  
Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Colorectal Carcinoma ◽  
Cell Cycle Arrest ◽  
Molecular Mechanisms ◽  
Annexin V ◽  
Fluorescein Isothiocyanate ◽  
Cycle Arrest ◽  
Ht29 Cells ◽  
G1 Cell Cycle Arrest

Colorectal carcinoma is one of the utmost diagnosed cancer with a steep increase in mortality rate. The incidence has been increasing in developing countries like India due to a westernization life style. Flavonoids have been explored widely for its various pharmacological activity including antitumor activity. Orientin, an analogue of luteolin (citrus flavonoid) isolated from rooibos and tulsi leaves is also expected to deliver significant antitumor activity similar to that of luteolin. The present study anticipates exploring the antitumor activity of orientin against colorectal carcinoma cells (HT29). Orientin exhibited remarkable cytotoxicity and antiproliferative activity against HT29 cells, which is clearly evident from tetrazolium based cytotoxicity and lactate dehydrogenase release assays. Orientin induce G0/G1 cell cycle arrest and regulates cyclin and cyclin-dependent protein kinases in order to prevent the entry of the cell cycle to the S phase. Annexin V-FITC (V-Fluorescein Isothiocyanate) dual staining reveals the apoptotic induction ability of orientin. The Bcl-2 family proteins along with the inhibitor of apoptotic proteins were regulated and the tumor suppressor p-53 expression have been decreased. In conclusion, our results proposed that orientin could be a potent chemotherapeutic agent against colorectal cancer after ascertaining their molecular mechanisms.

scholarly journals Olean-12-Eno[2,3-c] [1,2,5]Oxadiazol-28-Oic Acid (OEOA) Induces G1 Cell Cycle Arrest and Differentiation in Human Leukemia Cell Lines

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63580 ◽  
Author(s):  
Yu Pong Ng ◽  
Yuewen Chen ◽  
Yueqing Hu ◽  
Fanny C. F. Ip ◽  
Nancy Y. Ip
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Leukemia Cell ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Cycle Arrest ◽  
Leukemia Cell Lines ◽  
G1 Cell Cycle Arrest

scholarly journals Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells

2016 ◽  
Vol 13 (2) ◽  
pp. 1007-1013 ◽  
Author(s):  
Aisha Maimaitili ◽  
Zunhua Shu ◽  
Xiaojiang Cheng ◽  
Kadeer Kaheerman ◽  
Alifu Sikandeer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

The G1 cell cycle arrest of macrophages infected withAggregatibacter actinomycetemcomitans

Oral Diseases ◽  
2010 ◽  
Vol 16 (3) ◽  
pp. 305-309 ◽  
Author(s):  
H Kasai ◽  
K Nakashima ◽  
M Yokota ◽  
T Nishihara
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

1995 ◽  
Vol 9 (2) ◽  
pp. 204-217 ◽  
Author(s):  
M E Ewen ◽  
C J Oliver ◽  
H K Sluss ◽  
S J Miller ◽  
D S Peeper
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Tgf Beta ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

Marine Drugs ◽  
2017 ◽  
Vol 15 (6) ◽  
pp. 154 ◽  
Author(s):  
Hye Park ◽  
Shin-Hyung Park ◽  
Jin-Woo Jeong ◽  
Dahye Yoon ◽  
Min Han ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colorectal Carcinoma ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Human Colorectal Carcinoma
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