25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress

2020 ◽  
Vol 880 ◽  
pp. 173165 ◽  
Author(s):  
Qianqian Dong ◽  
Yanting Chen ◽  
Wantao Liu ◽  
Xiaoyu Liu ◽  
An Chen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Vascular Calcification

scholarly journals Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Rui Yang ◽  
Xu Teng ◽  
Hui Li ◽  
Hong-Mei Xue ◽  
Qi Guo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Endoplasmic Reticulum ◽  
Smooth Muscle ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress ◽  
Vascular Calcification ◽  
Vascular Smooth Muscle Cells ◽  
Rat Aorta ◽  
Prevention And Treatment ◽  
Phenotype Transformation

In this study, the vitamin D3plus nicotine (VDN) model of rats was used to prove that H2S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC). Besides, H2S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues. The effect of H2S on alleviating VC and phenotype transformation of VSMC can be blocked by TM, while PBA also alleviated VC and phenotype transformation of VSMC that was similar to the effect of H2S. These results suggest that H2S may alleviate rat aorta VC by inhibiting ERS, providing new target and perspective for prevention and treatment of VC.

Endoplasmic reticulum stress-mediated apoptosis is activated in vascular calcification

2009 ◽  
Vol 387 (4) ◽  
pp. 694-699 ◽  
Author(s):  
Xiaohui Duan ◽  
Yebo Zhou ◽  
Xu Teng ◽  
Chaoshu Tang ◽  
Yongfen Qi
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Vascular Calcification
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