scholarly journals Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

2020 ◽  
Vol 155 ◽  
pp. 105553 ◽  
Author(s):  
Anam Fayyaz ◽  
Veli-Pekka Ranta ◽  
Elisa Toropainen ◽  
Kati-Sisko Vellonen ◽  
Annika Valtari ◽  
...  
Keyword(s):  
Ocular Pharmacokinetics

scholarly journals Topical Drug Delivery to the Posterior Segment of the Eye

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 134
Author(s):  
Marina Löscher ◽  
Chiara Seiz ◽  
José Hurst ◽  
Sven Schnichels
Keyword(s):  
Drug Delivery ◽  
Animal Models ◽  
Treatment Option ◽  
Topical Treatment ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Posterior Segment ◽  
Retinal Diseases ◽  
Topical Drug Delivery ◽  
Ocular Pharmacokinetics

Topical drug delivery to the posterior segment of the eye is a very complex challenge. However, topical delivery is highly desired, to achieve an easy-to-use treatment option for retinal diseases. In this review, we focus on the drug characteristics that are relevant to succeed in this challenge. An overview on the ocular barriers that need to be overcome and some relevant animal models to study ocular pharmacokinetics are given. Furthermore, a summary of substances that were able to reach the posterior segment after eye drop application is provided, as well as an outline of investigated delivery systems to improve ocular drug delivery. Some promising results of substances delivered to the retina suggest that topical treatment of retinal diseases might be possible in the future, which warrants further research.

Comparative Study of Ocular Pharmacokinetics of Gatifloxacin Between Continuous Lavage and Hourly Topical Instillation in Rabbits

Cornea ◽  
2018 ◽  
Vol 37 (11) ◽  
pp. 1457-1462 ◽  
Author(s):  
Xin Zhao ◽  
Xu Shen ◽  
Xian Zhang ◽  
Shichao Chen ◽  
Hong Lu ◽  
...  
Keyword(s):  
Comparative Study ◽  
Ocular Pharmacokinetics

scholarly journals Ocular Pharmacokinetics of Naringenin Eye Drops Following Topical Administration to Rabbits

2015 ◽  
Vol 31 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Junli Lin ◽  
Jingjing Sun ◽  
Yandong Wang ◽  
Yan Ma ◽  
Wenpei Chen ◽  
...  
Keyword(s):  
Topical Administration ◽  
Eye Drops ◽  
Ocular Pharmacokinetics

Ocular pharmacokinetics of trimetazidine in the pigmented rat after a single oral administration

1992 ◽  
Vol 55 ◽  
pp. 55
Author(s):  
Pierre P. Elena ◽  
Eric Khosravi ◽  
Philippe Lapalus ◽  
Yves Joulin ◽  
Catherine Harpey
Keyword(s):  
Oral Administration ◽  
Ocular Pharmacokinetics ◽  
Single Oral Administration
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