Comparison of co-former performance in co-amorphous formulations: Single amino acids, amino acid physical mixtures, amino acid salts and dipeptides as co-formers

Among the nitrogen-containing organic substances there are compounds with a dual function. Particularly important are amino acids. Strictly speaking, amino acids make up only one of the many families of organic compounds. Any organic molecule having at least one amino and one acid group may be assigned to this family. This generally means any hydrocarbon chain that may be branched, with or without other functional groups, aromatic rings, or any other organic structure. Therefore, it becomes clear that the number of amino acids that can be imagined is infinite. Today in Russia there is an urgent need to develop new and effective drugs for the treatment of various diseases. This important task involves organizing the production of new competitive domestic medicines on the market, the development of which is carried out on the basis of the results of fundamental scientific research in the field of organic synthesis. In this regard, derivatives and salts of amino acids are of great interest, due to their high reactivity and wide use in medical practice. We have studied the effect on the hemostasis system of derivatives based on amino acid salts, which is currently a key task of organic, bioorganic and medicinal chemistry. Consideration of the scientific literature on this topic showed the saturation and increasing interest in the influence of amino acid compounds throughout the world. The synthesis of amino acid salts and the study of their effect on the blood curability system was carried out, optimal synthesis methods for an organic compound were developed. Preliminary in vitro preclinical studies of the obtained compounds were carried out in order to find out the prospects for their further use.

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State-of-the-art of CO2 capture with amino acid salt solutions

Reviews in Chemical Engineering ◽

10.1515/revce-2020-0012 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Rouzbeh Ramezani ◽

Saeed Mazinani ◽

Renzo Di Felice

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Physicochemical Properties ◽

Constant Density ◽

Acid Salt ◽

Salt Solutions ◽

Capture Process ◽

Amino Acid Salt ◽

Amino Acid Salts ◽

Acid Salts

AbstractThe emission of large amounts of CO2 into the atmosphere is believed to be a major reason behind climate change, which has led to increased demand for CO2 capture. Postcombustion CO2 capture with chemical solvent is considered one of the most important technologies in order to reduce CO2 emission. Amino acid salt solutions have attracted special attention in recent years due to their excellent physicochemical properties, e.g., low volatility, less toxicity, and high oxidative stability, as well as capture performance comparable with conventional amines. In this study, physicochemical properties of 20 amino acids are reported and their CO2 absorption performance discussed. The topics covered in this review include the most relevant properties of amino acids including CO2 loading capacity, cyclic capacity, equilibrium constant, density, viscosity, dissociation constant, CO2 solubility, CO2 diffusivity, reaction kinetic between CO2 and amino acid salts, reaction rate constant, surface tension, heat of CO2 absorption, precipitation, toxicity, solvent degradation, and corrosion rate. This review provides the most recent information available in the literature on the potential of using amino acid salts as a solvent for CO2 capture which can help improve the performance of the CO2 capture process from flue gas streams.

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Self-assembled ionic nanofibers derived from amino acids for high-performance particulate matter removal

Journal of Materials Chemistry A ◽

10.1039/c8ta11382c ◽

2019 ◽

Vol 7 (9) ◽

pp. 4619-4625 ◽

Cited By ~ 16

Author(s):

Lei Zhang ◽

Wen-Li Yuan ◽

Zhang Zhang ◽

Guo-Hao Zhang ◽

Hao Chen ◽

...

Keyword(s):

Amino Acids ◽

Particulate Matter ◽

Amino Acid ◽

Self Assembly ◽

High Performance ◽

Assembly Process ◽

Air Filters ◽

Amino Acid Salts ◽

Acid Salts

High-performance air filters were prepared by a simple in situ ionic self-assembly process of amino acid salts.

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Racemization of Optically Active Amino Acid Salts and an Approach to Asymmetric Transformation of DL-Amino Acids

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.56.3744 ◽

1983 ◽

Vol 56 (12) ◽

pp. 3744-3747 ◽

Cited By ~ 13

Author(s):

Chikara Hongo ◽

Ryuzo Yoshioka ◽

Masanori Tohyama ◽

Shigeki Yamada ◽

Ichiro Chibata

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Optically Active ◽

Amino Acid Salts ◽

Active Amino Acid ◽

Asymmetric Transformation ◽

Acid Salts

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New hydrophobicL-amino acid salts: maleates ofL-leucine,L-isoleucine andL-norvaline

Acta Crystallographica Section C Structural Chemistry ◽

10.1107/s2053229615010888 ◽

2015 ◽

Vol 71 (7) ◽

pp. 584-592 ◽

Cited By ~ 13

Author(s):

Sergey G. Arkhipov ◽

Denis A. Rychkov ◽

Alexey M. Pugachev ◽

Elena V. Boldyreva

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Second Harmonic Generation ◽

Crystal Structures ◽

Harmonic Generation ◽

Second Harmonic ◽

Side Chains ◽

Hydrophobic Amino Acid ◽

Amino Acid Salts ◽

Acid Salts

Crystals of maleates of three amino acids with hydrophobic side chains [L-leucenium hydrogen maleate, C6H14NO2+·C4H3O4−, (I), L-isoleucenium hydrogen maleate hemihydrate, C6H14NO2+·C4H3O4−·0.5H2O, (II), and L-norvalinium hydrogen maleate–L-norvaline (1/1), C5H11NO2+·C4H3O4−·C5H12NO2, (III)], were obtained. The new structures containC22(12) chains, or variants thereof, that are a common feature in the crystal structures of amino acid maleates. The L-leucenium salt is remarkable due to a large number of symmetrically non-equivalent units (Z′ = 3). The L-isoleucenium salt is a hydrate despite the fact that L-isoleucine is a nonpolar hydrophobic amino acid (previously known amino acid maleates formed hydrates only with lysine and histidine, which are polar and hydrophilic). The L-norvalinium salt provides the first example where the dimeric cation L-Nva...L-NvaH+was observed. All three compounds have layered noncentrosymmetric structures. Preliminary tests have shown the presence of the second harmonic generation (SGH) effect for all three compounds.

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