Potential use of point shear wave elastography for the pancreas: A single center prospective study

Shear-wave elastography (SWE) showed the absence or presence of significant differences among stable kidney allograft function and allograft dysfunction. We evaluated the variability of kidney allograft stiffness in relation to allograft dysfunction, respectively, in terms of a correlation of stiffness with patients’ characteristics. A single-center prospective study on patients who had undergone renal transplantation was conducted between October 2017 and November 2018. Patients were clinically classified as having a stable allograft function or allograft dysfunction. SWE examinations performed by the same radiologist with a LOGIQ E9 were evaluated. Ten measurements were done for Young’s modulus (kPa) at the level of allograft cortex and another ten at the level of medulla. Eighty-three SWE examinations from 63 patients, 69 stable allografts, and 14 allografts with dysfunction were included in the analysis. The intra-examinations stiffness showed high variability, with the quantile covariation coefficient ranging from 2.21% to 45.04%. The inter-examinations stiffness showed heterogeneity (from 28.66% to 42.38%). The kidney allograft cortex stiffness showed significantly higher values in cases with dysfunction (median = 28.70 kPa, interquartile range (IQR) = (25.68–31.98) kPa) as compared to those with stable function (median = 20.99 kPa, interquartile range = (16.08–27.68) kPa; p-value = 0.0142). Allograft tissue stiffness (both cortex and medulla) was significantly negatively correlated with body mass index (−0.44, p-value < 0.0001 for allograft cortex and −0.42, p-value = 0.0001 for allograft medulla), and positively correlated with Proteinuria/Creatinuria ratio (0.33, p-value = 0.0021 for allograft cortex and 0.28, p-value = 0.0105 for allograft medulla) but remained statistically significant only in cases with stable function. The cortical tissue stiffness proved significantly higher values for patients with allograft dysfunction as compared to patients with stable function, but to evolve as an additional tool for the evaluation of patients with a kidney transplant and to change the clinical practice, more extensive studies are needed.

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Liver Stiffness Assessed by Real-Time Two-dimensional Shear Wave Elastography Predicts Hypersplenism in Patients with Wilson’s Disease: A Prospective Study

10.21203/rs.3.rs-612351/v1 ◽

2021 ◽

Author(s):

Jiajia Wang ◽

Minxia Hu ◽

Qiang Zhu ◽

Lanting Sun

Keyword(s):

Risk Factors ◽

Prospective Study ◽

Real Time ◽

Shear Wave ◽

Wilson’S Disease ◽

Liver Stiffness ◽

Shear Wave Elastography ◽

Wilson's Disease ◽

Dynamic Monitoring ◽

Two Dimensional

Abstract Background To explore the value of liver stiffness assessed by two-dimensional real-time shear wave elastography (2D-SWE）in predicting the occurrence of hypersplenism in patients diagnosed with Wilson’s disease (WD). Methods A total of 90 WD patients were enrolled in this prospective study between May 2018 and December 2018. Clinical data and ultrasound imaging including 2D-SWE liver stiffness of WD patients as baseline data were collected. Patients were followed up for 24 months, or patients developed hypersplenism after enrollment. Risk factors for hypersplenism were determined using cox regression and receiver operating characteristic curve. Results Twenty-night (32.2%) patients were found developed hypersplenism. The age, the diameter of portal vein, and the liver stiffness were independent risk factors associated with hypersplenism in WD. The cutoff value of liver stiffness for predicting hypersplenism was 10.45 kPa, with sensitivity and specificity of 75.9% and 73.8%, respectively. When patients were divided into two groups according to liver stiffness ≥10.45 kPa or <10.45 kPa, the incidence of hypersplenism were 57.9% vs. 13.5% (P<0.001), and the median time between the enrollment and the development of hypersplenism was 15 months vs. 22 months (P<0.001) for the two groups, respectively. Conclusion The liver stiffness measured by 2D-SWE was a reliable predictor of hypersplenism in WD patients. Dynamic monitoring WD patients using 2D-SWE is crucial for the early diagnosis of hypersplenism.

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