scholarly journals Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study

Diagnostics ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 41
Author(s):  
Sorana D. Bolboacă ◽  
Florin Ioan Elec ◽  
Alina Daciana Elec ◽  
Adriana Milena Muntean ◽  
Mihai Adrian Socaciu ◽  
...  
Keyword(s):  
Shear Wave ◽  
Shear Wave Elastography ◽  
Interquartile Range ◽  
P Value ◽  
Single Center ◽  
Tissue Stiffness ◽  
Kidney Allograft ◽  
Stable Function ◽  
Allograft Dysfunction ◽  
Allograft Function

Shear-wave elastography (SWE) showed the absence or presence of significant differences among stable kidney allograft function and allograft dysfunction. We evaluated the variability of kidney allograft stiffness in relation to allograft dysfunction, respectively, in terms of a correlation of stiffness with patients’ characteristics. A single-center prospective study on patients who had undergone renal transplantation was conducted between October 2017 and November 2018. Patients were clinically classified as having a stable allograft function or allograft dysfunction. SWE examinations performed by the same radiologist with a LOGIQ E9 were evaluated. Ten measurements were done for Young’s modulus (kPa) at the level of allograft cortex and another ten at the level of medulla. Eighty-three SWE examinations from 63 patients, 69 stable allografts, and 14 allografts with dysfunction were included in the analysis. The intra-examinations stiffness showed high variability, with the quantile covariation coefficient ranging from 2.21% to 45.04%. The inter-examinations stiffness showed heterogeneity (from 28.66% to 42.38%). The kidney allograft cortex stiffness showed significantly higher values in cases with dysfunction (median = 28.70 kPa, interquartile range (IQR) = (25.68–31.98) kPa) as compared to those with stable function (median = 20.99 kPa, interquartile range = (16.08–27.68) kPa; p-value = 0.0142). Allograft tissue stiffness (both cortex and medulla) was significantly negatively correlated with body mass index (−0.44, p-value < 0.0001 for allograft cortex and −0.42, p-value = 0.0001 for allograft medulla), and positively correlated with Proteinuria/Creatinuria ratio (0.33, p-value = 0.0021 for allograft cortex and 0.28, p-value = 0.0105 for allograft medulla) but remained statistically significant only in cases with stable function. The cortical tissue stiffness proved significantly higher values for patients with allograft dysfunction as compared to patients with stable function, but to evolve as an additional tool for the evaluation of patients with a kidney transplant and to change the clinical practice, more extensive studies are needed.

scholarly journals Shear Wave Elastography in Evaluating Acute Kidney Allograft Dysfunction: Preliminary Results.

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Carmen Roch ◽  
Fernando García ◽  
María Flores ◽  
Ruben González ◽  
Miguel Cepeda ◽  
...  
Keyword(s):  
Shear Wave ◽  
Gold Standard ◽  
Clinical Signs ◽  
Standard Technique ◽  
Shear Wave Elastography ◽  
Tissue Stiffness ◽  
Preliminary Results ◽  
Non Invasive ◽  
Allograft Dysfunction ◽  
Gold Standard Technique

In absence of pharmacological toxicity, allograft dysfunction is usually due to parenchymal inflammation and tubulointerstitial fibrosis, but its clinical signs are often non-specific and tend to appear when advanced damage has been established. We investigated whether Shear Wave Elastography (SWE), a new non-invasive ultrasound (US) based technique that estimates tissue stiffness, could provide early confident diagnosis of acute allograft dysfunction compared to biopsy (gold standard technique).

Comparison of ultrasound shear wave elastography with magnetic resonance elastography and renal microvascular flow in the assessment of chronic renal allograft dysfunction

2017 ◽  
Vol 59 (9) ◽  
pp. 1139-1145 ◽  
Author(s):  
Stephan R Marticorena Garcia ◽  
Jing Guo ◽  
Michael Dürr ◽  
Timm Denecke ◽  
Bernd Hamm ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Shear Wave ◽  
Renal Allograft ◽  
Characteristic Curve ◽  
Shear Wave Elastography ◽  
Magnetic Resonance Elastography ◽  
Image Resolution ◽  
Microvascular Flow ◽  
Allograft Dysfunction ◽  
Allograft Function

Background Monitoring of renal allograft function is essential for early identification of dysfunction and improvement of kidney transplant (KTX) outcome. Purpose To non-invasively assess renal stiffness in KTX recipients using ultrasound shear wave elastography (USE) in correlation with multifrequency magnetic resonance elastography (MRE), renal allograft function, and renal microvascular flow determined using a novel ultrasound microvascular imaging technique. Material and Methods This prospective study investigated 25 KTXs (functional KTX [FCT], n = 14; chronic KTX insufficiency [DYS], n = 11) in 20 KTX recipients (mean age = 43 ± 14 years). USE was performed using a high-frequency broadband linear transducer and compared with MRE. Shear wave velocity (SWV) was correlated with the estimated glomerular filtration rate (eGFR). Qualitative differences in renal microvascular flow were obtained using SMI. Results FCT had higher SWV than DYS in both cortex and pyramids (cortex, FCT: 3.75 ± 0.82 m/s vs. DYS: 2.79 ± 0.73 m/s, P = 0.0002; pyramid, FCT: 2.89 ± 0.46 m/s vs. DYS: 2.39 ± 0.34 m/s, P = 0.044). Cutoff values of 3.265 m/s for cortex, 2.535 m/s for pyramids, and 2.985 m/s for combined non-hilar parenchyma provided sensitivities of 72.7%, 77.8%, and 90.9% and specificities of 71.4%, 78.6%, and 85.7% for detecting renal allograft dysfunction with area under the receiver operating characteristic curve (AUC) values of 0.831, 0.841, 0.925 (95% confidence interval [CI] = 0.67–0.99, 0.66–1.02, 0.83–1.03). USE correlated positively with eGFR ( r = 0.741, P = 0.0004) and with MRE-derived SWV ( r = 0.562, P = 0.004). Renal microvascular flow was decreased in DYS. Conclusion USE is sensitive to renal allograft dysfunction, which is characterized by reduced SWV and renal perfusion. USE has higher image resolution than MRE, while MRE has slightly better diagnostic accuracy.

Potential use of point shear wave elastography for the pancreas: A single center prospective study

2014 ◽  
Vol 83 (4) ◽  
pp. 620-624 ◽  
Author(s):  
Natsuko Kawada ◽  
Sachiko Tanaka ◽  
Hiroyuki Uehara ◽  
Kazuyoshi Ohkawa ◽  
Takuo Yamai ◽  
...  
Keyword(s):  
Prospective Study ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Single Center ◽  
Potential Use

Comparison of peritumoral stromal tissue stiffness obtained by shear wave elastography between benign and malignant breast lesions

2018 ◽  
Vol 59 (10) ◽  
pp. 1168-1175 ◽  
Author(s):  
Hye Sun Park ◽  
Hee Jung Shin ◽  
Ki Chang Shin ◽  
Joo Hee Cha ◽  
Eun Young Chae ◽  
...  
Keyword(s):  
Shear Wave ◽  
Malignant Tumors ◽  
Shear Wave Elastography ◽  
Breast Cancers ◽  
Tissue Stiffness ◽  
Linear Arrangement ◽  
Luminal B ◽  
Tumor Subtypes ◽  
Stromal Tissue ◽  
Malignant Breast

Background Aggressive breast cancers produce abnormal peritumoral stiff areas, which can differ between benign and malignant lesions and between different subtypes of breast cancer. Purpose To compare the tissue stiffness of the inner tumor, tumor border, and peritumoral stroma (PS) between benign and malignant breast masses by shear wave elastography (SWE). Material and Methods We enrolled 133 consecutive patients who underwent preoperative SWE. Using OsiriX commercial software, we generated multiple 2-mm regions of interest (ROIs) in a linear arrangement on the inner tumor, tumor border, and PS. We obtained the mean elasticity value (Emean) of each ROI, and compared the Emean between benign and malignant tumors. Odds ratios (ORs) for prediction of malignancy were calculated. Subgroup analyses were performed among tumor subtypes. Results There were 85 malignant and 48 benign masses. The Emean of the tumor border and PS were significantly different between benign and malignant masses ( P < 0.05 for all). ORs for malignancy were 1.06, 1.08, 1.05, and 1.04 for stiffness of the tumor border, proximal PS, middle PS, and distal PS, respectively ( P < 0.05 for all). Malignant masses with a stiff rim were significantly larger than malignant masses without a stiff rim, and were more commonly associated with the luminal B and triple negative subtypes. Conclusion Stiffness of the tumor border and PS obtained by SWE were significantly different between benign and malignant masses. Malignant masses with a stiff rim were larger in size and associated with more aggressive pathologic subtypes.

scholarly journals Strain Elastography - How To Do It?

2017 ◽  
Vol 03 (04) ◽  
pp. E137-E149 ◽  
Author(s):  
Christoph Dietrich ◽  
Richard Barr ◽  
André Farrokh ◽  
Manjiri Dighe ◽  
Michael Hocke ◽  
...  
Keyword(s):  
Shear Wave ◽  
Wave Speed ◽  
Shear Wave Elastography ◽  
Ultrasound Elastography ◽  
Tissue Stiffness ◽  
Shear Wave Speed ◽  
Strain Elastography ◽  
Advantages And Disadvantages ◽  
Similar Information ◽  
Qualitative Technique

AbstractTissue stiffness assessed by palpation for diagnosing pathology has been used for thousands of years. Ultrasound elastography has been developed more recently to display similar information on tissue stiffness as an image. There are two main types of ultrasound elastography, strain and shear wave. Strain elastography is a qualitative technique and provides information on the relative stiffness between one tissue and another. Shear wave elastography is a quantitative method and provides an estimated value of the tissue stiffness that can be expressed in either the shear wave speed through the tissues in meters/second, or converted to the Young’s modulus making some assumptions and expressed in kPa. Each technique has its advantages and disadvantages and they are often complimentary to each other in clinical practice. This article reviews the principles, technique, and interpretation of strain elastography in various organs. It describes how to optimize technique, while pitfalls and artifacts are also discussed.

scholarly journals Visualization of the shear wave on gray-scale ultrasound: experience with a complex breast cyst

2020 ◽  
Vol 22 (4) ◽  
pp. 492
Author(s):  
Angelica Chiorean ◽  
Roxana Maria Pintican ◽  
Maria Magdalena Duma ◽  
Radu Fechete ◽  
Diana Feier ◽  
...  
Keyword(s):  
Shear Wave ◽  
Shear Wave Elastography ◽  
Breast Disease ◽  
Solid Content ◽  
Tissue Stiffness ◽  
Gray Scale ◽  
Breast Cyst ◽  
Fibrocystic Breast Disease ◽  
Gray Scale Image ◽  
The Impact

Shear wave elastography (SWE) is the newer of the two methods of measuring tissue stiffness using ultrasound. We present the case of a 39-year-old patient with fibrocystic breast disease who presented with a left painful breast lump. The patient underwent a breast ultrasound that depicted a complicated cyst with a “pseudo-solid” content. When the SWE mode was turned on, the ultrasound share wave was observed on the gray-scale image, as surface undulations of the “pseudo-solid” component. To the best of our knowledge, this is the first report of the share wave visualization on a gray-scale image. The impact on patient management is discussed. 

scholarly journals Performance of 2D-SWE.GE for predicting different stages of liver fibrosis, using Transient Elastography as the reference method

2017 ◽  
Vol 19 (2) ◽  
pp. 143 ◽  
Author(s):  
Felix Bende ◽  
Ioan Sporea ◽  
Roxana Sirli ◽  
Alina Popescu ◽  
Ruxandra Mare ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Shear Wave ◽  
Strong Correlation ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Reference Method ◽  
Shear Wave Elastography ◽  
Interquartile Range ◽  
General Electric

Aim: To evaluate the performance of 2D shear-wave elastography from General Electric (2D-SWE.GE) for the noninvasiveassessment of liver fibrosis and to identify liver stiffness (LS) cut-off values for predicting different stages of fibrosisusing Transient Elastography (TE) as the reference method. Material and method: We included 331 consecutive subjectswith or without chronic hepatopathies in whom LS was evaluated in the same session by means of 2 elastographic techniques:TE and 2D-SWE.GE. Reliable LS measurements were defined for TE as the median value of 10 measurements with a successrate of ≥60% and an interquartile range (IQR)<30% and for 2D-SWE.GE as the median value of 10 measurements acquiredin a homogenous area and an IQR<30%. To discriminate between TE fibrosis stages we used the following cut-offs: F2- 7;F3- 9.5 and F4- 12kPa. Results: Reliable LS measurements were obtained in 95.8% subjects by 2D-SWE.GE, and 94.2%by TE (p=0.44). Based on TE cut-off values we divided our cohort into four groups: F<2: 30.1%; F=2: 10.2%; F=3: 12.2%;F=4: 47.5%. A strong correlation was found between the LS values obtained by the 2 methods: r=0.83, p<0.0001.LS valuesobtained by 2D-SWE.GE were significantly lower than those obtained by TE: 10.14±4.24 kPa vs. 16.72±13.4 kPa (p<0.0001).The best cut-off value for F≥2, F≥3 and for F=4 were 6.7, 8.2 and 9.3 kPa. Conclusions: The best 2D-SWE.GE cut-off valuesfor predicting F≥2, F≥3 and F=4 were 6.7, 8.2 and 9.3kPa.

Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis

2018 ◽  
Vol 25 (5) ◽  
pp. 450-455 ◽  
Author(s):  
Maggie KM Ma ◽  
Helen KW Law ◽  
Kin Sun Tse ◽  
Kwok Wah Chan ◽  
Gary CW Chan ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Kidney Allograft ◽  
Non Invasive ◽  
Pathological Correlation

Assessing Hepatic Fibrosis Using 2-D Shear Wave Elastography in Patients with Liver Tumors: A Prospective Single-Center Study

2017 ◽  
Vol 43 (11) ◽  
pp. 2522-2529 ◽  
Author(s):  
Zhongxi Huang ◽  
Wei Zheng ◽  
Yao-Jun Zhang ◽  
Li Xu ◽  
Jin-Bin Chen ◽  
...  
Keyword(s):  
Shear Wave ◽  
Hepatic Fibrosis ◽  
Liver Tumors ◽  
Shear Wave Elastography ◽  
Single Center ◽  
Single Center Study ◽  
Center Study
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