Brachial artery flow mediated dilatation and carotid intima media thickness measured by high resolution B-mode ultrasound in patients with rheumatoid arthritis

Introduction: Cardiovascular diseases (CVDs) are the main cause of morbidity and mortality in RA disease. In active RA patients, the majority of cardiovascular deaths result from accelerates atherosclerosis. Aim of the Work: The aim of this work is to assess carotid intima media thickness (C-IMT) and endothelial function by brachial artery flow mediated dilatation (FMD) in Rheumatoid arthritis patients and relation to the disease activity. Subjects and Methods: Our study included 50 RA patients, from Tanta University Hospital. 47 women and 3 men and their age ranged from 30-62 years. They were divided into group 1: 25 active RA patients, group 2: 25 inactive RA patients who were diagnosed by American College of Rheumatology (ACR) revised criteria for diagnosis of RA 1987 and disease activity was evaluated using disease activity score 28(DAS28). Group 3: 25 normal subjects as a control group. We measured C-IMT and FMD in all groups. Results: By comparing the groups, we found that active RA patients had increased C-IMT compared to inactive rheumatoid arthritis patients and controls which is indicator of atherosclerosis. FMD of the brachial artery impaired in RA patients compared to controls which is indicator of endothelial dysfunction. There was highly statistically significant relation between duration, activity of RA disease and atherosclerosis in RA patients. Conclusion: With increasing the frequency of atherosclerosis in asymptomatic RA patients, carotid IMT increased and FMD impaired when compared with general population. Active RA patients have increased carotid IMT and impaired FMD compared with inactive RA patients.

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Correlation of Coronary Angiographic Severity with Carotid intima Media Thickness and Flow mediated dilatation of brachial Artery in Patients with Ischemic Heart Disease

Cardiovascular Journal ◽

10.3329/cardio.v5i2.14321 ◽

2013 ◽

Vol 5 (2) ◽

pp. 165-172

Author(s):

SME Mahabub ◽

AEMM Islam ◽

KMN Sabah ◽

AW Chowdhury ◽

M Ghiasuddin ◽

...

Keyword(s):

Heart Disease ◽

Ischemic Heart Disease ◽

Brachial Artery ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Ischemic Heart ◽

Media Thickness ◽

Flow Mediated Dilatation ◽

Extent Score ◽

Vessel Score

Background: Ischemic Heart Disease which encompasses Acute Coronary Syndrome and Chronic Stable Angina is the most common cause of worldwide mortality and morbidity. Carotid intima media thickness (CIMT) is a non-invasive ultrasonographic technique to image the carotid arteries which measures the thickness of the intima and media of these vessels. It is a marker of atherosclerotic process. Flow mediated dilatation (FMD) is a marker of endothelial function of arteries. Ischemic heart disease can be predicted long before its actual occurrence by observing these two phenomenons. Methods: This cross sectional study done in the Department of Cardiology, Dhaka Medical College Hospital during the period of Oct 2010- Sept 2011.We enrolled 102 patients admitted with IHD by purposive sampling. We assessed FMD of brachial artery, CIMT by vascular duplex. Coronary artery disease severity was assessed by vessel score, stenosis score and extent score from angiography. Results:The mean (±SD) age of the patients was 50.9(±11.3) years. The male- female ratio was 5:1. CIMT has significant negative correlation with FMD (r=-.407, p=<.001). Flow mediated dilatation of brachial artery has weak but significant negative co-relation with vessel score(r=-.609, p=<.001), stenosis score(r=- .493, p=<.001) and extent score (r=-.477, p=<.001). However, carotid intima media thickness has weak but positive correlation with vessel score (r=.447, p=<.001), stenosis score (r=.417, p=<.001) and extent score(r=.412, p=<.001). Conclusion: The present study concludes CIMT has significant negative correlation with flow mediated dilatation of brachial artery. FMD has weak but significant negative co-relation and CIMT has weak but positive correlation with vessel score, stenosis score and extent score of coronary arteries. DOI: http://dx.doi.org/10.3329/cardio.v5i2.14321 Cardiovasc. j. 2013; 5(2): 165-172

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Epicardial adipose tissue thickness, flow-mediated dilatation of the brachial artery, and carotid intima–media thickness

Herz ◽

10.1007/s00059-014-4140-z ◽

2014 ◽

Vol 40 (S3) ◽

pp. 217-224 ◽

Cited By ~ 10

Author(s):

A. Temiz ◽

F. Gökmen ◽

E. Gazi ◽

A. Akbal ◽

A. Barutçu ◽

...

Keyword(s):

Adipose Tissue ◽

Brachial Artery ◽

Epicardial Adipose Tissue ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Tissue Thickness ◽

Media Thickness ◽

Epicardial Adipose Tissue Thickness ◽

Flow Mediated Dilatation

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The combined use of brachial artery flow-mediated dilatation and carotid artery intima-media thickness measurements may be a method to determine vasculogenic erectile dysfunction

International Journal of Impotence Research ◽

10.1038/sj.ijir.3901572 ◽

2007 ◽

Vol 19 (6) ◽

pp. 577-583 ◽

Cited By ~ 12

Author(s):

G Ucar ◽

M Secil ◽

O Demir ◽

T Demir ◽

A Comlekci ◽

...

Keyword(s):

Erectile Dysfunction ◽

Carotid Artery ◽

Brachial Artery ◽

Intima Media Thickness ◽

Media Thickness ◽

Combined Use ◽

Flow Mediated Dilatation ◽

Artery Flow ◽

Thickness Measurements ◽

Vasculogenic Erectile Dysfunction

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Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis patients

Scientific Reports ◽

10.1038/s41598-021-95234-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Delia Taverner ◽

Dídac Llop ◽

Roser Rosales ◽

Raimon Ferré ◽

Luis Masana ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Cardiovascular Disease ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Disease Risk ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness ◽

Epigenetic Biomarkers

AbstractTo validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic microRNAs, which we previously identified and that can facilitate earlier diagnosis of cardiovascular disease in rheumatoid arthritis patients. We identified 10 plasma miRs that were downregulated in male rheumatoid arthritis patients and in patients with acute myocardial infarction compared to controls suggesting that these microRNAs could be epigenetic biomarkers for cardiovascular disease in rheumatoid arthritis patients. Six of those microRNAs were validated in independent plasma samples from 214 rheumatoid arthritis patients and levels of expression were associated with surrogate markers of cardiovascular disease (carotid intima-media thickness, plaque formation, pulse wave velocity and distensibility) and with prior cardiovascular disease. Multivariate analyses adjusted for traditional confounders and treatments showed that decreased expression of microRNA-425-5p in men and decreased expression of microRNA-451 in women were significantly associated with increased (β = 0.072; p = 0.017) and decreased carotid intima-media thickness (β = −0.05; p = 0.013), respectively. MicroRNA-425-5p and microRNA-451 also increased the accuracy to discriminate patients with pathological carotid intima-media thickness by 1.8% (p = 0.036) in men and 3.5% (p = 0.027) in women, respectively. In addition, microRNA-425-5p increased the accuracy to discriminate male patients with prior cardiovascular disease by 3% (p = 0.008). Additionally, decreased expression of microRNA-451 was significantly associated with decreased pulse wave velocity (β = −0.72; p = 0.035) in overall rheumatoid arthritis population. Distensibility showed no significant association with expression levels of the microRNAs studied. We provide evidence of a possible role of microRNA-425-5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.

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