scholarly journals A study of margin width and local recurrence in breast conserving therapy for invasive breast cancer

2016 ◽  
Vol 42 (5) ◽  
pp. 657-664 ◽  
Author(s):  
J.M. Dixon ◽  
J. Thomas ◽  
G.R. Kerr ◽  
L.J. Williams ◽  
C. Dodds ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Breast Conserving Therapy ◽  
Margin Width

scholarly journals Risk Factors of Local Recurrence after Breast Conserving Therapy in Invasive Breast Cancer

2009 ◽  
Vol 12 (4) ◽  
pp. 302 ◽  
Author(s):  
On Vox Yi ◽  
Jong Won Lee ◽  
Hee Jung Kim ◽  
Woo Sung Lim ◽  
Eun Hwa Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Breast Conserving Therapy

The relationship between findings on pre-treatment mammograms and local recurrence after breast-conserving therapy for invasive breast cancer

1999 ◽  
Vol 25 (3) ◽  
pp. 273-279 ◽  
Author(s):  
A.C. Voogd ◽  
F. van der Horst ◽  
M.A. Crommelin ◽  
J.L. Peterse ◽  
M.W.P.M. van Beek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Breast Conserving Therapy ◽  
Pre Treatment ◽  
The Relationship

Local Recurrence After Breast-Conserving Therapy for Invasive Breast Cancer: High Incidence in Young Patients and Association with Poor Survival

1998 ◽  
Vol 40 (4) ◽  
pp. 859-867 ◽  
Author(s):  
Paula H.M Elkhuizen M.D. ◽  
Marc J van de Vijver M.D., Ph.D. ◽  
Jo Hermans Ph.D. ◽  
Harmien M Zonderland M.D. ◽  
Cornelis J.H van de Velde M.D., Ph.D. ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Young Patients ◽  
Breast Conserving Therapy ◽  
Poor Survival ◽  
High Incidence

Histological determinants for different types of local recurrence after breast-conserving therapy of invasive breast cancer

1999 ◽  
Vol 35 (13) ◽  
pp. 1828-1837 ◽  
Author(s):  
A.C. Voogd ◽  
J.L. Peterse ◽  
M.A. Crommelin ◽  
E.J.Th. Rutgers ◽  
G. Botke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Breast Conserving Therapy ◽  
Different Types

scholarly journals Impact of Surgical Margins in Breast Cancer After Preoperative Systemic Chemotherapy on Local Recurrence and Survival

2019 ◽  
Vol 27 (5) ◽  
pp. 1700-1707 ◽  
Author(s):  
K. Wimmer ◽  
M. Bolliger ◽  
Z. Bago-Horvath ◽  
G. Steger ◽  
D. Kauer-Dorner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Complete Response ◽  
Breast Conserving Therapy ◽  
Free Survival ◽  
Margin Width ◽  
Primary Surgery ◽  
Significant Difference

Abstract Background While “no tumour on ink” is an accepted margin width for R0 resection in primary surgery, it’s unclear if it’s oncologically safe after neoadjuvant chemotherapy (NAC). Only limited data demonstrate that surgery within new margins in cases of a pathological complete response (pCR) is safe. We therefore investigated the influence of different margins and pCR on local recurrence and survival rates after NAC. Methods We retrospectively analysed data of 406 women with invasive breast cancer, treated with NAC and breast-conserving therapy between 1994 and 2014 in two certified Austrian breast health centres. We compared R ≤ 1 mm, R > 1 mm and RX (pCR) for local recurrence-free survival (LRFS), disease-free survival (DFS) and overall survival (OS). Results After a median follow-up of 84.3 months, the 5-year LRFS (R ≤ 1 mm: 94.2%, R > 1 mm: 90.6%, RX: 95.0%; p = 0.940), the 5-year DFS (R ≤ 1 mm: 71.9%, R > 1 mm: 74.1%, RX: 87.2%; p = 0.245) and the 5-year OS (R ≤ 1 mm: 85.1%, R > 1 mm: 88.0%, RX: 96.4%; p = 0.236) did not differ significantly between narrow, wide, nor RX resections. Regarding DFS and OS, a negative nodal status reduced the hazard ratio significantly. Conclusion There is no significant difference in LRFS, DFS and OS comparing close, wide or unknown margins after pCR. We suggest that resection in new margins after NAC is safe according to “no tumour on ink”. Resection of the clipped area in cases of pCR is emphasized.

Sign in / Sign up

Export Citation Format

Share Document