Absolute or Ratio Of Lymph Node Involvement in Oesophago-Gastric cancer? Impact On Survival- An 8 Year Pilot Study

Of 431 patients with gastric cancer observed in our Istitution, 23 (5.3 %) had early gastric cancer (EGC). Macroscopic presentation, histology, depth of invasion, and lymph node involvement were evaluated in all the cases. All patients underwent surgery and an intensive follow-up was performed. Five of the 23 patients progressed, and the risk factors were examined. Histology seemed to be the main prognostic factor in our study, since intestinal type of EGC was associated to a significantly better prognosis. Total gastrectomy is indicated in the proximal localization of EGC, and should perhaps be performed also in cases presenting undifferentiated histology.

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Long-term prognosis of patients with gastric cancer in stage UICC I without lymph-node involvement.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e15068 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e15068-e15068

Author(s):

Christoph Treese ◽

Pedro Sanchez ◽

Ioannis Anagnostopoulos ◽

Peter M. Schlag ◽

Michael Kruschewski ◽

...

Keyword(s):

Gastric Cancer ◽

Risk Factor ◽

Lymph Node ◽

Early Stage ◽

Expression Profiles ◽

Lymph Node Involvement ◽

Term Survival ◽

Immunohistochemical Markers ◽

Node Involvement

e15068 Background: Despite radical oncologic resection with extended lymph node removal, patients with adenocarcinoma of the gastro-esophageal junction or stomach in UICC stage I show only a 5-year survival of 60-80% (Hölscher et al, 2009; Siewert et al. 1998). The aim of this retrospective study was to analyze the long-term survival of caucasian patients with early stage gastric cancer as for this population exist only sparse data. Patients with lymph-node involvement were not included as this parameter is a well-known negative prognostic marker. Methods: Tissue specimens and clinical data from patients with gastric cancer treated in the years 1993 to 2010 at the Charité, Berlin were collected retrospectively. Patients with stage T1 and T2 pN0M0 gastric cancer treated only by surgery including D1- and D2-lymphnode dissection were included in this study. Patients without relapse were followed-up for a minimum period of 24 months. Results: 97 patients (w = 36, m = 61, age 29-90 years) with a follow-up time from 6 to 208 months were identified. The 5-year survival was 94.85% (for details, see Table). Conclusions: The present data indicate a much better prognosis (5-year survival of 95%) of UICC I patients than previously described (60-80%). In harmony with other studies, our data demonstrate that R1, L1 or V1 resection seem to be a risk factor for recurrence whereas signet-ring differentiation was not found as a risk factor in our patient cohort. Ongoing work involves a broad panel of immunohistochemical markers to select prognostic expression profiles which help to identify patients with early gastric cancer at higher risk. This study was supported by the Berliner Krebsgesellschaft, grant DAFF201101. [Table: see text]

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Prediction of prognosis with neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and pathological parameters in operated gastric cancer

Medical Science and Discovery ◽

10.36472/msd.v7i11.440 ◽

2020 ◽

Vol 7 (11) ◽

pp. 703-708

Author(s):

Ozlem Mermut ◽

Berrin Inanc

Keyword(s):

Gastric Cancer ◽

Overall Survival ◽

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Involvement ◽

High Morbidity ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Platelet Lymphocyte Ratio ◽

Node Involvement

Objective: Inflammatory markers are of prognostic importance in many malignancies. This study aimed to examine the effects of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and pathological parameters on survival in preoperative complete blood counts in patients with operated gastric cancer. Material and Methods: Between 2012 and 2017, 281 patients were analyzed after total/subtotal gastrectomy. According to the ROC curve, we determined the cut-off values for NLR as 2.5 and PLR as 158. Overall survival (OS) was calculated from surgery to the last interview or to death. Results: In univariate analysis age ≥ 55 (p = 0.028), non-adeno hystology (p = 0.003), lenfovascular invasion (LVI) positivity (p = 0.003), perineural invasion (PNI) positivity (p < 0.001), T 3-4 stage (p = 0.006), lymph node involvement (LN) 2-3 (p < 0.001), metastatic stage (p < 0.001), NLR ≥ 2.5 ( p<0.001) and PLR ≥ 158 (p < 0.001) were statistically significant for OS. In multivariate analysis age (HR 0.652, 95% CI: 0.475-0.895; p = 0.008), PNI positivity (HR 0.493, 95% CI: 0.337-0.720; p<0.001), more lymph node involvement (HR: 0.608, 95% CI:0.412-0.896, p = 0.012), metastatic stage (HR 0.377, 95% CI: 0.265-0.537; p < 0.001) and PLR ≥ 158 (HR: 0.610; 95% CI: 0.433-0.859; p = 0.005) were found to be independent prognostic factors affecting OS. Conclusion: Age ≥ 55, PNI positivity, more lymph node involvement, metastatic stage, and PLR ≥ 158 are independent prognostic factors for shorter overall survival. Given the high morbidity and mortality of gastric cancer, besides classical known prognostic factors, parameters such as preoperative PLR may have benefits for forecast the prognosis of gastric cancer.

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False-Positive Lymph Node Involvement by PET-CT in an Early Gastric Cancer: Kikuchi Fujimoto Disease

Turkiye Klinikleri Journal of Case Reports ◽

10.5336/caserep.2020-77721 ◽

2021 ◽

Vol 29 (1) ◽

pp. 13-16

Author(s):

Sami ACAR

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Early Gastric Cancer ◽

False Positive ◽

Lymph Node Involvement ◽

Positive Lymph Node ◽

Pet Ct ◽

Node Involvement

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Modified Gastric Cancer AJCC Staging with a Classification Based on the Ratio of Regional Lymph Node Involvement: A Population-Based Cohort Study

Annals of Surgical Oncology ◽

10.1245/s10434-019-08098-w ◽

2019 ◽

Vol 27 (5) ◽

pp. 1480-1487 ◽

Cited By ~ 1

Author(s):

Zeping Huang ◽

Yutong Chen ◽

Wenjun Zhang ◽

Haipeng Liu ◽

Zixian Wang ◽

...

Keyword(s):

Gastric Cancer ◽

Cohort Study ◽

Lymph Node ◽

Regional Lymph Node ◽

Lymph Node Involvement ◽

Population Based ◽

Regional Lymph Node Involvement ◽

Node Involvement ◽

Ajcc Staging

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Grading as a Prognostic Factor: Review of 209 Primary Gastric Cancer Patients

Tumori Journal ◽

10.1177/030089168907500520 ◽

1989 ◽

Vol 75 (5) ◽

pp. 494-497 ◽

Cited By ~ 1

Author(s):

Giovanni Battista Secco ◽

Roberto Fardelli ◽

Elisabetta Campora ◽

Salvatore Rovida ◽

Gabriella Lapertosa ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Tumor Grade ◽

Tumor Stage ◽

Lymph Node Involvement ◽

Primary Gastric Cancer ◽

Node Involvement ◽

Involvement Rate ◽

Well Differentiated ◽

Gastric Cancer Patients

Two hundred and nine cases of primary gastric cancer were treated surgically from January 1968 to December 1983 and analyzed retrospectively. All patients were followed up for a minimum of 5 years. There were 25 SI cases (12 %), 22 SII (10.5%), 55 SIII (26.3%) and 107 SIV (51.2%). Tumor grade according to Broders classification showed 50 cases of G1 lesions (23.9%), 44 G2 (21.1 %) and 115 G3 (55%). Patients with well differentiated G1 lesion, compared to G2-G3 patients, presented a greater incidence of T1-T2 tumors and decreased incidence of T4 tumors (p < 0.05). The lymph node involvement rate significantly increased with variation of T (p < 0.001) but not with tumor grade. Survival results correlated with tumor stage (p < 0.01) but not with tumor grade or histological type.

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Prognostic value of Serum and Tumor Tissue CA 72-4 Content in Gastric Cancer

The International Journal of Biological Markers ◽

10.1177/172460080301800104 ◽

2003 ◽

Vol 18 (1) ◽

pp. 21-27 ◽

Cited By ~ 15

Author(s):

S. Aloe ◽

R. D'alessandro ◽

A. Spila ◽

P. Ferroni ◽

S. Basili ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Prognostic Value ◽

Tumor Tissue ◽

Prognostic Significance ◽

Lymph Node Involvement ◽

Depth Of Invasion ◽

Free Survival ◽

Tissue Content ◽

Node Involvement

To date no general agreement has been reached regarding the prognostic significance of CEA, CA 19-9 and CA 72-4 as serum markers in gastric cancer, and only scattered information is available on the predictive value of marker expression in tumor tissue. Therefore, a longitudinal study was designed to analyze the presurgical serum and tumor tissue content of CA 72-4, CEA and CA 19-9 in 166 patients at different stages of gastric cancer, and to evaluate the possible correlation with clinicopathological features in respect to prognostic information on relapse-free survival. The results obtained showed that 48.4% of patients with tumor recurrence had positive presurgical CA 72-4 levels compared to approximately 24% of patients who remained free of disease. Furthermore, the median presurgical serum CA 72-4 levels were significantly elevated in relapsing patients. Serosa and lymph node involvement as well as positive presurgical serum CA 72-4 levels had independent prognostic value in predicting recurrence. A significant association between disease-free survival and lymph node involvement, depth of invasion and tumor tissue content of CA 72-4 was also demonstrated. We may therefore conclude that CA 72-4 antigen can be considered the marker of choice in the follow-up of gastric cancer patients and may be used as a prognostic indicator of relapse.

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The role of hilar lymphadenectomy in patients subjected to hepatectomy due to colorectal metastasis

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032011000300012 ◽

2011 ◽

Vol 48 (3) ◽

pp. 217-219 ◽

Cited By ~ 2

Author(s):

Eduardo Freitas Viana ◽

Paulo Herman ◽

Fabrício Ferreira Coelho ◽

Thomas Augusto Taka ◽

Luiz A. Carneiro D'Albuquerque ◽

...

Keyword(s):

Lymph Node ◽

Liver Resection ◽

Survival Rates ◽

Lymph Node Involvement ◽

Hilar Lymph Node ◽

Disease Staging ◽

Impact On Survival ◽

Node Involvement ◽

Long Term Prognosis ◽

Improvement In Survival

CONTEXT: Hepatectomy is the treatment of choice for colorectal liver metastases, and several studies have shown good results, with 5-year survival rates ranging from 40% to 57%. Several clinical and pathological predictive factors for survival after liver resection have been studied. Involvement of the hepatic hilum lymph nodes, the incidence of which varies from 2% to 10%, indicates a poor long-term prognosis. RESULTS: Despite variable results, some authors have reported a not-insignificant improvement in survival rate in liver-metastasis patients with hilar lymph node involvement who undergo combined liver resection and lymphadenectomy. Due to the low rates of morbidity and mortality for liver-resection surgery, several specialized centers perform liver resections combined with lymphadenectomies in selected cases. It should be noted that the therapeutic value of systemic lymphadenectomy is not yet entirely understood, and only controlled studies comparing groups with and without lymphadenectomy can fully resolve the issue. CONCLUSION: In any case, hilar lymph node dissection has been shown to be a useful tool for improving the accuracy of extra hepatic disease staging, regardless of its impact on survival.

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