Fracture mechanics of blood clots: Measurements of toughness and critical length scales

2021 ◽  
pp. 101444
Author(s):  
Shiyu Liu ◽  
Guangyu Bao ◽  
Zhenwei Ma ◽  
Christian J. Kastrup ◽  
Jianyu Li
2021 ◽  
Author(s):  
Shiyu Liu ◽  
Guangyu Bao ◽  
Zhenwei Ma ◽  
Christian Kastrup ◽  
Jianyu Li

Blood coagulates to plug vascular damage and stop bleeding, and thus the function of blood clots in hemostasis depends on their resistance against rupture (toughness). Despite the significance, fracture mechanics of blood clots remains largely unexplored, particularly the measurements of toughness and critical length scales governing clot fracture. Here, we study the fracture behavior of human whole blood clots and platelet-poor plasma clots. The fracture energy of whole blood clots and platelet-poor plasma clots determined using modified lap-shear method is 5.90 +- 1.18 J/m2 and 0.96 +- 0.90 J/m2, respectively. We find that the measured toughness is independent of the specimen geometry and loading conditions. These results reveal a significant contribution of blood cells to the clot fracture, as well as the dissipative length scale and nonlinear elastic length scale governing clot fracture.


2004 ◽  
Vol 467-470 ◽  
pp. 1039-1044 ◽  
Author(s):  
Elizabeth A. Holm ◽  
J.H. Meinke ◽  
E.S. McGarrity ◽  
P.M. Duxbury

With the development of new, fully three-dimensional metallographic techniques, there is considerable interest in characterizing three-dimensional microstructures in ways that go beyond twodimensional stereology. One characteristic of grain structures is the surface of lowest energy across the microstructure, termed the critical manifold (CM). When the grain boundaries are sufficiently weak, the CM lies entirely on grain boundaries, while when the grain boundaries are strong, cleavage occurs. A scaling theory for the cleavage to intergranular transition of CMs is developed. We find that a critical length scale exists, so that on short length scales cleavage is observed, while at long length scales the CM is rough. CMs for realistic polycrystalline grain structures, determined by a network optimization algorithm, are used to verify the analysis.


2009 ◽  
Vol 633-634 ◽  
pp. 647-653 ◽  
Author(s):  
Nathan A. Mara ◽  
D. Bhattacharyya ◽  
Patricia O. Dickerson ◽  
R.G. Hoagland ◽  
Amit Misra

In recent years, the high strength of nanomaterials has gathered much interest in the materials community. Nanomaterials (polycrystalline and composites) have already been used, largely by the semiconductor community, as critical length scales for chip design have decreased to tens of nanometers. However, to ensure reliability of nanomaterials, the mechanisms underlying their structural integrity must be well understood. For these materials to be put into service, not only should their strength be considered, but also ductility, toughness, formability, and fatigue resistance. While some progress has been made into constructing models for the deformation mechanisms governing these behaviors, the body of experimental knowledge is still limited, especially for length scales below 10 nanometers. The results described here show stress-strain curves for nanolaminate composites with individual layer thickness of 40 nm and 5 nm. Nanolaminate composites fabricated via magnetron sputtering comprised of alternating 5 nm thick Cu and Nb multilayers (two relatively soft metals) exhibit strengths on par with hardened tool steel and deformability in compression in excess of 25% [1]. The deformability of nanoscale composites is found to be limited by the onset of geometric instability.


2002 ◽  
Vol 117 (19) ◽  
pp. 9063-9073 ◽  
Author(s):  
A. A. Lefebvre ◽  
J. H. Lee ◽  
N. P. Balsara ◽  
C. Vaidyanathan

2006 ◽  
Vol 306-308 ◽  
pp. 691-696 ◽  
Author(s):  
Indera Sadikin ◽  
Djoko Suharto

The dynamic nature of marine environment is the major cause of fatigue failures in subsea gas pipeline structures. Since the severest loaded part of piping system is the free span, freespan inspection is performed periodically to ensure that no free span exceeds its critical length. The objective of this paper is to optimize free-span inspection interval by means of probabilistic fracture mechanics analysis. Simulation data is taken from previous work of Tronskar [1]. Stress intensity factors at the crack tip are calculated by crack closure technique. Fatigue crack growth is simulated by cycle-by-cycle integration technique. The fracture mechanics analysis is then expanded to probabilistic analysis to include stochastic input parameters. Probability of failure is computed by modified direct simulation method. Based on the result of direct simulation, the studied pipelines are recommended to be inspected every 3 years to make sure that no free span exceeds 30 m.


Nanoscale ◽  
2016 ◽  
Vol 8 (12) ◽  
pp. 6456-6462 ◽  
Author(s):  
Wenjie Xia ◽  
Luis Ruiz ◽  
Nicola M. Pugno ◽  
Sinan Keten

Three critical length scales govern the deformation mechanisms and constitutive response of multi-layer graphene.


2020 ◽  
Author(s):  
David Kammer ◽  
Ilya Svetlizky ◽  
Jay Fineberg

<p>Shear ruptures propagating along natural faults or simulated faults in analog laboratory experiments present a wide range of rupture velocities. Most ruptures propagate at velocities below the Rayleigh wave speed and Linear Elastic Fracture Mechanics (LEFM) theory has been shown to predict quantitatively well the observed propagation speed. However, early theoretical and numerical work suggested that ruptures may surpass the shear wave speed and propagate at velocities that can reach the longitudinal wave speed. This was later confirmed in laboratory experiments and observed as supershear earthquakes in nature. While the transition from sub-Rayleigh to supershear propagation has been studied extensively, current knowledge of propagation speed in the supershear regime is limited to a couple of idealistic set-ups. Here, we analyse the propagation speed of supershear ruptures along various nonuniform interfaces using simulations and experiments. We show that an approximate fracture mechanics theory describes well supershear rupture speeds as observed in our experiments and simulations. Furthermore, the theory uncovers a critical rupture length below which supershear propagation is impossible. Beyond this critical length, a rupture can sustain supershear propagation for arbitrarily low prestress levels if local non-uniformities cause transition. The presented theory provides a tool to better understand the potential for supershear ruptures in more realistic heterogeneous systems.</p>


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