Incidental versus clinical diagnosis of papillary thyroid microcarcinoma. Long-term prognosis

Abstract PurposesDistant metastasis from papillary thyroid microcarcinoma (PTMC) is extremely rare and the long-term outcome and independent prognostic factors remain unclear.The present study aimed to investigate clinicopathological characteristics and evaluate the long-term outcomes and prognostic factors of PTMC patients with distant metastases (DM) who underwent surgery and radioactive iodine (131I) treatment.MethodsWe retrospectively reviewed the medical records of 13,441 patients with thyroid cancer (including 1,697 cases with PTMC) who underwent 131I treatment at our institution between January 2008 and December 2019. PTMC patients with distant metastases with sufficient clinical follow-up data were enrolled in this cohort study. The overall survival (OS) and progression-free survival (PFS) were analyzed by the Kaplan–Meier method and the prognostic factors were assessed by Cox proportional hazards. ResultsThirty-three PTMC patients with DM were enrolled in this study. The median follow-up was 75 months (range: 5–151 months).The 5-year and 10-year OS rates were 96.97% and 81.41%, respectively, and the 5-year and 10-year PFS rates were 90.46% and 69.68%, respectively. Multivariate analysis showed that male sex(P=0.005) , radioactive iodine refractory PTMC (P=0.033) and symptomatic DM (P=0.022) were significantly associated with worse 10-year PFS in PTMC patients with DM. No independent predictor related to poor 10-year OS found in the present study.ConclusionsThe prognosis of PTMC patients becomes worse after the development of DM. Male sex, radioactive iodine refractory PTMC and symptomatic DM were identified as independent factors associated with PFS.

Download Full-text

Long-term outcomes of radiofrequency ablation for unifocal low-risk papillary thyroid microcarcinoma: a large cohort study of 414 patients

European Radiology ◽

10.1007/s00330-020-07128-6 ◽

2020 ◽

Cited By ~ 2

Author(s):

Lin Yan ◽

Yu Lan ◽

Jing Xiao ◽

Lin Lin ◽

Bo Jiang ◽

...

Keyword(s):

Cohort Study ◽

Radiofrequency Ablation ◽

Large Cohort ◽

Low Risk ◽

Papillary Thyroid Microcarcinoma ◽

Papillary Thyroid ◽

Long Term Outcomes ◽

Thyroid Microcarcinoma ◽

Large Cohort Study

Download Full-text

Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-018-2607-7 ◽

2018 ◽

Vol 144 (4) ◽

pp. 771-779 ◽

Cited By ~ 29

Author(s):

Dengke Teng ◽

Guoqing Sui ◽

Caimei Liu ◽

Yu Wang ◽

Yongxu Xia ◽

...

Keyword(s):

Low Power ◽

Microwave Ablation ◽

Papillary Thyroid Microcarcinoma ◽

Papillary Thyroid ◽

Ultrasound Guided ◽

Follow Up Study ◽

Thyroid Microcarcinoma ◽

Power Microwave

Download Full-text

Influence of ultrasound-guided fine needle aspiration biopsy on cervical lymph node metastasis and prognosis of papillary thyroid microcarcinoma

10.21203/rs.3.rs-1036349/v1 ◽

2021 ◽

Author(s):

Ding Min ◽

Zhifeng Zhao ◽

Dan Xu ◽

Tingyu Lin ◽

Dongjie Shen ◽

...

Keyword(s):

Cervical Lymph Node ◽

Thyroid Nodules ◽

Cervical Lymph Node Metastasis ◽

Papillary Thyroid ◽

Node Metastasis ◽

Thyroid Microcarcinoma ◽

Kaplan Meier ◽

Significant Difference ◽

Long Term Prognosis

Abstract Purpose To analyze the potential association between UGFNA and cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) and whether it would influence the long-term prognosis of PTMC. Then we could give advice for the application of UGFNA for thyroid nodules less than 1cm. Methods A total of 367 adult patients with PTMC who underwent thyroidectomy in our hospital during January 2014 and December 2015 were enrolled in this retrospective cohort study. Univariate and multivariate analysis were conducted to explore the potential risk factors of CLNM. Propensity score (PS) matching was performed to select patients with homogeneous baseline characteristics. Then the rate of CLNM was compared in matched samples by chi-squared (χ2). Survival analysis was made by Kaplan-Meier method in PS-matching cohort. Results CLNM rate in PS-matching cohort showed no significant difference between UGFNA group and non-UGFNA group. (29.5% vs 23.7%, P>0.05). Multivariate analysis showed that male sex (OR=3.997, 95%CI 2.148~7.439, P<0.01), larger tumor size (OR=2.319, 95%CI 1.285~4.186, P<0.01) were independent risk factors of CLNM. With a median follow-up of 63.8 months (range 3.1-84.9 months), the 5-year cumulative recurrence-free survival (RFS) rate was 99.3% in UGFNA group and 97.7% in non-UGFNA group. After PS-matching, Kaplan-Meier curves showed no significant difference from each other (P >0.05). Conclusions UGFNA was a very safe diagnostic tool, which would not influence the CLNM rate and long-term prognosis of patients with PTMC. Regardless of the costs, we recommend routine UGFNA for suspicious thyroid nodules ≦1cm.

Download Full-text