Phytotoxicity and oxidative stress effect of 1-octyl-3-methylimidazolium chloride ionic liquid on rice seedlings

2013 ◽  
Vol 181 ◽  
pp. 242-249 ◽  
Author(s):  
Huijun Liu ◽  
Shuxian Zhang ◽  
Xiaona Hu ◽  
Caidong Chen
PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245474
Author(s):  
Thi Thanh Huong Pham ◽  
Wan-Ying Huang ◽  
Chang-Shi Chen ◽  
Wen-Tai Chiu ◽  
Han-Sheng Chuang

Antioxidant uptake and regular exercise are two well-acknowledged measures used for rejuvenation and oxidative stress elimination. Previous studies have revealed that moderate exercise mildly increases intracellular signaling oxidant levels and strengthens the ability of an organism to deal with escalating oxidative stress by upregulating antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase. Antioxidant supplementation directly scavenges intracellular reactive oxygen species (ROS) to reduce oxidative stress. However, research to understand the impacts of these enzymes on mitigating oxidative stress from the perspective of simple animals is limited. Herein, we show that exercise combined with antioxidant supplementation ameliorates the physiological phenotypes and markers of aging in wild-type and SOD/CAT-deficient Caenorhabditis elegans. We discovered that treated wild-type and gene-deficient worms show better survivorship, reproduction, and motility compared with their control counterparts. Assays of biochemical indices revealed that variations in sod-3 expression under different stress levels imply an inducible enzyme response resulting from exercise training and antioxidant supplementation. In addition, induced ROS resistance obtained from any type of treatment could persist for several days even after treatment cessation, thus suggesting a potential long-term antioxidative stress effect. Our findings confirm that exercise, antioxidant supplementation, and their combination could significantly improve the ability of C. elegans to withstand adverse stress. Our observations provide promising insights into future therapies of anti-oxidative stress in higher animals.


Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
B Fenton-Navarro ◽  
MV Urquiza-Martinez ◽  
B Fiscal-Castro ◽  
B Nateras-Marín ◽  
M López-Rodríguez ◽  
...  

Author(s):  
D.T. Fefar ◽  
Y.J. Khanpara ◽  
D.V. Joshi ◽  
B.J. Patel ◽  
S.K. Modi ◽  
...  

The present research work was conducted to study the haemato-biochemical and oxidative stress effect of subacute intramuscular administration of ketoprofen for 14 days on 24 female Wistar rats. The animals were equally divided into 4 different groups A, B, C, D during randomization and dosed with vehicle control, 4 mg/kg as low dose, 8 mg/kg as mid dose and 12 mg/kg as high dose of ketoprofen, respectively. The drug was administered by intramuscular route every day for 14 days. At the end of 14 days treatment, all the animals from group A to D were subjected to blood collection and haemato-biochemical and oxidative stress investigation. The haematological study revealed dose dependent decrease in Hb, PCV,TEC, lymphocyte per cent and MCHC in Group C and Group D rats, while increase in MCV and neutrophil per cent in Group C and Group D rats.Administration of ketoprofen caused reduction in serum total protein (Group C and Group D), albumin (Group C and Group D) and globulin (Group D) in different groups. The result suggested that long term administration of ketoprofen at dose rate of 8 mg/kg and 12 mg/kg leads to macrocytic hypochromic anaemia possibly because of gastrointestinal bleeding or micro-bleeding and it is also evident that ketoprofen at the dose rate of 8 mg/kg b.wt. and 12 mg/kg b.wt. results into oxidative stress.


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