A statistical analysis of the syphilis incidence in Moscow and regions from 2006 to 2017 was carried out. Despite a decrease in the general syphilis incidence an increase in incidence of such severe forms as late neurosyphilis and cardiovascular syphilis was observed. We analyzed 1,600 archive case histories of inpatients and outpatients of the Sechenov University clinics in Moscow and identified the specific lesions in heart tissues, blood vessels and the nervous system. in literal data a relatively small number of cardiosyphilis cases was described. it can be explained by the fact that earlier only gummas, that are rarely to be located in the heart and difficult to be identified clinically, were considered to be the only specific pathological and anatomical changes for syphilis of the heart.