Curcumin ameliorated the mercuric chloride induced depression and anxiety in female mice offspring

2021 ◽  
pp. 112031
Author(s):  
Gasem Mohammad Abu-Taweel ◽  
Hassan Ahmed Rudayni
Keyword(s):  
Mercuric Chloride ◽  
Depression And Anxiety ◽  
Female Mice

scholarly journals Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chloe E. Page ◽  
Ryan Shepard ◽  
Kelsey Heslin ◽  
Laurence Coutellier
Keyword(s):  
Prefrontal Cortex ◽  
Mouse Model ◽  
Mood Disorders ◽  
Chronic Stress ◽  
Inhibitory Interneurons ◽  
Depression And Anxiety ◽  
Female Mice ◽  
Physiological Properties ◽  
Chronic Activation ◽  
Reduced Activity

AbstractReduced activity of the prefrontal cortex (PFC) is seen in mood disorders including depression and anxiety. The mechanisms of this hypofrontality remain unclear. Because of their specific physiological properties, parvalbumin-expressing (PV+) inhibitory interneurons contribute to the overall activity of the PFC. Our recent work using a chronic stress mouse model showed that stress-induced increases in prefrontal PV expression correlates with increased anxiety-like behaviors in female mice. Our goal is now to provide a causal relationship between changes in prefrontal PV+ cells and changes in emotional behaviors in mice. We first show that, in addition to increasing overall level of PV expression, chronic stress increases the activity of prefrontal PV+ cells. We then used a chemogenetic approach to mimic the effects of chronic stress and specifically increase the activity of prefrontal PV+ cells. We observed that chemogenetic activation of PV+ cells caused an overall reduction in prefrontal activity, and that chronic activation of PV+ cells lead to increased anxiety-related behaviors in female mice only. These results demonstrate that activity of prefrontal PV+ cells could represent a novel sex-specific modulator of anxiety-related behaviors, potentially through changes in overall prefrontal activity. The findings also support the idea that prefrontal PV+ cells are worth further investigation to better understand mood disorders that are more prevalent in female populations.

Central forebrain Fos responses to familiar male odours are attenuated in recently mated female mice

2001 ◽  
Vol 13 (2) ◽  
pp. 389-399 ◽  
Author(s):  
Heather A. Halem ◽  
James A. Cherry ◽  
Michael J. Baum
Keyword(s):  
Female Mice ◽  
Mated Female

Individual Differences and Hemispheric Asymmetry While Processing Emotional Words

2014 ◽  
Vol 35 (3) ◽  
pp. 137-143 ◽  
Author(s):  
Lindsay M. Niccolai ◽  
Thomas Holtgraves
Keyword(s):  
Individual Differences ◽  
Hemispheric Asymmetry ◽  
Past Research ◽  
Decision Task ◽  
Depression And Anxiety ◽  
Hemispheric Differences ◽  
Affective Valence ◽  
Emotional Words ◽  
Emotion Words ◽  
The Right

This research examined differences in the perception of emotion words as a function of individual differences in subclinical levels of depression and anxiety. Participants completed measures of depression and anxiety and performed a lexical decision task for words varying in affective valence (but equated for arousal) that were presented briefly to the right or left visual field. Participants with a lower level of depression demonstrated hemispheric asymmetry with a bias toward words presented to the left hemisphere, but participants with a higher level of depression displayed no hemispheric differences. Participants with a lower level of depression also demonstrated a bias toward positive words, a pattern that did not occur for participants with a higher level of depression. A similar pattern occurred for anxiety. Overall, this study demonstrates how variability in levels of depression and anxiety can influence the perception of emotion words, with patterns that are consistent with past research.

Dimensionality and Reliability Assessment of the Pain Patient Profile Questionnaire

2008 ◽  
Vol 24 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Brian E. McGuire ◽  
Michael J. Hogan ◽  
Todd G. Morrison
Keyword(s):  
Self Report ◽  
Pain Patient ◽  
Fit Indices ◽  
Depression And Anxiety ◽  
Oblique Rotation ◽  
Pain Experience ◽  
Patient Profile ◽  
Adequate Representation ◽  
Pain Patients ◽  
Report Measure

Abstract. Objective: To factor analyze the Pain Patient Profile questionnaire (P3; Tollison & Langley, 1995 ), a self-report measure of emotional distress in respondents with chronic pain. Method: An unweighted least squares factor analysis with oblique rotation was conducted on the P3 scores of 160 pain patients to look for evidence of three distinct factors (i.e., Depression, Anxiety, and Somatization). Results: Fit indices suggested that three distinct factors, accounting for 32.1%, 7.0%, and 5.5% of the shared variance, provided an adequate representation of the data. However, inspection of item groupings revealed that this structure did not map onto the Depression, Anxiety, and Somatization division purportedly represented by the P3. Further, when the analysis was re-run, eliminating items that failed to meet salience criteria, a two-factor solution emerged, with Factor 1 representing a mixture of Depression and Anxiety items and Factor 2 denoting Somatization. Each of these factors correlated significantly with a subsample's assessment of pain intensity. Conclusion: Results were not congruent with the P3's suggested tripartite model of pain experience and indicate that modifications to the scale may be required.

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