scholarly journals 31. GENETIC CONTROL OF DECONVOLVED BRAIN CELL-TYPES

2021 ◽  
Vol 51 ◽  
pp. e57
Author(s):  
Chloe Yap ◽  
Chongyuan Luo ◽  
Dorothea Seiler Vellame ◽  
Arjun Bhattacharya ◽  
Alice Franklin ◽  
...  
Keyword(s):  
Genetic Control ◽  
Cell Types ◽  
Brain Cell ◽  
Brain Cell Types

Localization of migraine susceptibility genes in human brain by single-cell RNA sequencing

Cephalalgia ◽  
2018 ◽  
Vol 38 (13) ◽  
pp. 1976-1983 ◽  
Author(s):  
William Renthal
Keyword(s):  
Human Brain ◽  
Single Cell ◽  
Rna Sequencing ◽  
Expression Profiles ◽  
Cell Types ◽  
Susceptibility Genes ◽  
Brain Cell ◽  
Cell Type ◽  
Single Cell Rna Sequencing ◽  
Brain Cell Types

Background Migraine is a debilitating disorder characterized by severe headaches and associated neurological symptoms. A key challenge to understanding migraine has been the cellular complexity of the human brain and the multiple cell types implicated in its pathophysiology. The present study leverages recent advances in single-cell transcriptomics to localize the specific human brain cell types in which putative migraine susceptibility genes are expressed. Methods The cell-type specific expression of both familial and common migraine-associated genes was determined bioinformatically using data from 2,039 individual human brain cells across two published single-cell RNA sequencing datasets. Enrichment of migraine-associated genes was determined for each brain cell type. Results Analysis of single-brain cell RNA sequencing data from five major subtypes of cells in the human cortex (neurons, oligodendrocytes, astrocytes, microglia, and endothelial cells) indicates that over 40% of known migraine-associated genes are enriched in the expression profiles of a specific brain cell type. Further analysis of neuronal migraine-associated genes demonstrated that approximately 70% were significantly enriched in inhibitory neurons and 30% in excitatory neurons. Conclusions This study takes the next step in understanding the human brain cell types in which putative migraine susceptibility genes are expressed. Both familial and common migraine may arise from dysfunction of discrete cell types within the neurovascular unit, and localization of the affected cell type(s) in an individual patient may provide insight into to their susceptibility to migraine.

scholarly journals Virulent and attenuated canine distemper virus infects multiple dog brain cell types in vitro

Glia ◽  
1991 ◽  
Vol 4 (4) ◽  
pp. 408-416 ◽  
Author(s):  
Susan Pearce-Kelling ◽  
William J. Mitchell ◽  
Brian A. Summers ◽  
Max J. G. Appel
Keyword(s):  
Canine Distemper Virus ◽  
Cell Types ◽  
Brain Cell ◽  
Canine Distemper ◽  
Dog Brain ◽  
Brain Cell Types

The distribution of the histone H1° in different brain cell types

1982 ◽  
Vol 109 (1) ◽  
pp. 78-82 ◽  
Author(s):  
Martin R. Harris ◽  
Nerina Harborne ◽  
Bryan J. Smith ◽  
James Allan
Keyword(s):  
Cell Types ◽  
Histone H1 ◽  
Brain Cell ◽  
Brain Cell Types

Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease

2020 ◽  
Vol 87 (9) ◽  
pp. S110 ◽  
Author(s):  
Frank Wendt ◽  
Gita Pathak ◽  
Todd Lencz ◽  
John Krystal ◽  
Joel Gelernter ◽  
...  
Keyword(s):  
Mental Health ◽  
Socioeconomic Status ◽  
Cell Types ◽  
Brain Cell ◽  
Health And Disease ◽  
Brain Cell Types

F28SINGLE-CELL ENRICHMENT ANALYSIS FOR THE IDENTIFICATION OF TRAIT-RELEVANT GENES AND BRAIN CELL TYPES IN PSYCHIATRIC DISORDERS

2019 ◽  
Vol 29 ◽  
pp. S1124
Author(s):  
Diogo Marinho Almeida ◽  
Samuel Demharter ◽  
Thomas Werge ◽  
Konstantin Khodosevich ◽  
Alfonso Demur
Keyword(s):  
Psychiatric Disorders ◽  
Enrichment Analysis ◽  
Cell Types ◽  
Brain Cell ◽  
Cell Enrichment ◽  
Brain Cell Types

Differential expression of peroxiredoxin subtypes in human brain cell types

1999 ◽  
Vol 56 (2) ◽  
pp. 206-212
Author(s):  
Theodore A. Sarafian ◽  
M. Anthony Verity ◽  
Harry V. Vinters ◽  
Charles C.-Y. Shih ◽  
Liangru Shi ◽  
...  
Keyword(s):  
Human Brain ◽  
Differential Expression ◽  
Cell Types ◽  
Brain Cell ◽  
Brain Cell Types

scholarly journals SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

2020 ◽  
Author(s):  
Leon Fodoulian ◽  
Joel Tuberosa ◽  
Daniel Rossier ◽  
Madlaina Boillat ◽  
Chenda Kan ◽  
...  
Keyword(s):  
Sensory System ◽  
Cell Types ◽  
Sensory Epithelium ◽  
Brain Cell ◽  
Rna Seq ◽  
Angiotensin Converting Enzyme 2 ◽  
Sustentacular Cells ◽  
The Brain ◽  
Brain Cell Types ◽  
Human And Mouse

AbstractVarious reports indicate an association between COVID-19 and anosmia, suggesting an infection of the olfactory sensory epithelium, and thus a possible direct virus access to the brain. To test this hypothesis, we generated RNA-seq libraries from human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the virus receptor angiotensin-converting enzyme-2 (ACE2), and for the virus internalization enhancer TMPRSS2. We analyzed a human olfactory single-cell RNA-seq dataset and determined that sustentacular cells, which maintain the integrity of olfactory sensory neurons, express ACE2 and TMPRSS2. We then observed that the ACE2 protein was highly expressed in a subset of sustentacular cells in human and mouse olfactory tissues. Finally, we found ACE2 transcripts in specific brain cell types, both in mice and humans. Sustentacular cells thus represent a potential entry door for SARS-CoV-2 in a neuronal sensory system that is in direct connection with the brain.

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