A genome-wide association study on fish consumption in a Japanese population—the Japan Multi-Institutional Collaborative Cohort study

2020 ◽  
Author(s):  
Taro Suzuki ◽  
◽  
Yasuyuki Nakamura ◽  
Keitaro Matsuo ◽  
Isao Oze ◽  
...  
Keyword(s):  
Cohort Study ◽  
Association Study ◽  
Fish Consumption ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

A Genome-wide Association Study on Confection Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study

2021 ◽  
pp. 1-37
Author(s):  
Taro Suzuki ◽  
Yasuyuki Nakamura ◽  
Yukio Doi ◽  
Akira Narita ◽  
Atsushi Shimizu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Association Study ◽  
Japanese Population ◽  
Alcohol Intake ◽  
Genome Wide Association Study ◽  
Sweet Taste ◽  
Taste Perception ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Abstract Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social, or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analyzed GWAS data on sweets consumption using 14,073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with sweets consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1 to 3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/day) in addition to the above-described variables. We found 418 single nucleotide polymorphisms (SNPs) located in 12q24 that were associated with sweets consumption. SNPs with the 10 lowest P-values were located on nine genes including at the BRAP, ACAD10, and ALDH2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with sweets intake with genome-wide significance. In conclusion, we found a significant number of SNPs located on 12q24 genes that were associated with sweets intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake.

scholarly journals Replication of a genome-wide association study of panic disorder in a Japanese population

2009 ◽  
Vol 55 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Takeshi Otowa ◽  
Hisashi Tanii ◽  
Nagisa Sugaya ◽  
Eiji Yoshida ◽  
Ken Inoue ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Association Study ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population

2012 ◽  
Vol 44 (4) ◽  
pp. 430-434 ◽  
Author(s):  
Chizu Tanikawa ◽  
Yuji Urabe ◽  
Keitaro Matsuo ◽  
Michiaki Kubo ◽  
Atsushi Takahashi ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Association Study ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

2012 ◽  
Vol 44 (8) ◽  
pp. 900-903 ◽  
Author(s):  
Kouya Shiraishi ◽  
Hideo Kunitoh ◽  
Yataro Daigo ◽  
Atsushi Takahashi ◽  
Koichi Goto ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Association Study ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yasuo Takahashi ◽  
Keiko Yamazaki ◽  
Yoichiro Kamatani ◽  
Michiaki Kubo ◽  
Koichi Matsuda ◽  
...  
Keyword(s):  
Association Study ◽  
Resistant Hypertension ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Neuron Development ◽  
Candidate Locus ◽  
Asian Populations ◽  
Genome Wide ◽  
A Genome

AbstractNumerous genetic variants associated with hypertension and blood pressure are known, but there is a paucity of evidence from genetic studies of resistant hypertension, especially in Asian populations. To identify novel genetic loci associated with resistant hypertension in the Japanese population, we conducted a genome-wide association study with 2705 resistant hypertension cases and 21,296 mild hypertension controls, all from BioBank Japan. We identified one novel susceptibility candidate locus, rs1442386 on chromosome 18p11.3 (DLGAP1), achieving genome-wide significance (odds ratio (95% CI) = 0.85 (0.81–0.90), P = 3.75 × 10−8) and 18 loci showing suggestive association, including rs62525059 of 8q24.3 (CYP11B2) and rs3774427 of 3p21.1 (CACNA1D). We further detected biological processes associated with resistant hypertension, including chemical synaptic transmission, regulation of transmembrane transport, neuron development and neurological system processes, highlighting the importance of the nervous system. This study provides insights into the etiology of resistant hypertension in the Japanese population.

scholarly journals Genome wide association study of HTLV-1–associated myelopathy/tropical spastic paraparesis in the Japanese population

2021 ◽  
Vol 118 (11) ◽  
pp. e2004199118
Author(s):  
Marina Penova ◽  
Shuji Kawaguchi ◽  
Jun-ichirou Yasunaga ◽  
Takahisa Kawaguchi ◽  
Tomoo Sato ◽  
...  
Keyword(s):  
Amino Acid ◽  
Association Study ◽  
Proviral Load ◽  
Odds Ratio ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Increased Risk

HTLV-1–associated myelopathy (HAM/TSP) is a chronic and progressive inflammatory disease of the central nervous system. The aim of our study was to identify genetic determinants related to the onset of HAM/TSP in the Japanese population. We conducted a genome-wide association study comprising 753 HAM/TSP patients and 899 asymptomatic HTLV-1 carriers. We also performed comprehensive genotyping of HLA-A, -B, -C, -DPB1, -DQB1, and -DRB1 genes using next-generation sequencing technology for 651 HAM/TSP patients and 804 carriers. A strong association was observed in HLA class I (P = 1.54 × 10−9) and class II (P = 1.21 × 10−8) loci with HAM/TSP. Association analysis using HLA genotyping results showed that HLA-C*07:02 (P = 2.61 × 10−5), HLA-B*07:02 (P = 4.97 × 10−10), HLA-DRB1*01:01 (P = 1.15 × 10−9) and HLA-DQB1*05:01 (P = 2.30 × 10−9) were associated with disease risk, while HLA-B*40:06 (P = 3.03 × 10−5), HLA-DRB1*15:01 (P = 1.06 × 10−5) and HLA-DQB1*06:02 (P = 1.78 × 10−6) worked protectively. Logistic regression analysis identified amino acid position 7 in the G-BETA domain of HLA-DRB1 as strongly associated with HAM/TSP (P = 9.52 × 10−10); individuals homozygous for leucine had an associated increased risk of HAM/TSP (odds ratio, 9.57), and proline was protective (odds ratio, 0.65). Both associations were independent of the known risk associated with proviral load. DRB1-GB-7-Leu was not significantly associated with proviral load. We have identified DRB1-GB-7-Leu as a genetic risk factor for HAM/TSP development independent of proviral load. This suggests that the amino acid residue may serve as a specific marker to identify the risk of HAM/TSP even without knowledge of proviral load. In light of its allele frequency worldwide, this biomarker will likely prove useful in HTLV-1 endemic areas across the globe.

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