P.0422 CLOCK gene variation mediates effect of early childhood adversities and recent stressors on current depressive symptoms

In a previous study of the Child-Parent Centers (CPC) education program, preschool participation was linked to a 4.6 percentage point reduction (26%) in depressive symptoms at ages 22–24 over the matched comparison group enrolling the usual programs. The present study reanalyzed these data in the Chicago Longitudinal Study to address potential attrition bias since more than a quarter of the sample was missing on the outcome. Using inverse probability weighting (IPW) involving 32 predictors of sample retention, findings for the 1,142 participants growing up in high-poverty neighborhoods indicated that CPC participation was associated with a 7.1 percentage point reduction (95% CI = [−9.7, −5.4]) in one or more depressive symptoms (39% reduction over the comparison group). Although this marginal effect was within the confidence interval of the original study (95% CI = [−9.5, 0.3]), the 54% increase in the point estimate is substantial and of practical significance, suggesting underestimation in the prior study. Alternative analysis of different predictors and IPW models, including adjustments for program selection and attrition together, yielded similar results. Findings indicate that high-quality early childhood programs continue to be an important strategy for the prevention of depression and its debilitating effects on individuals and families.

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Childhood adversities and mid-late depressive symptoms over the life course: Evidence from the China health and retirement longitudinal study

Journal of Affective Disorders ◽

10.1016/j.jad.2018.11.028 ◽

2019 ◽

Vol 245 ◽

pp. 668-678 ◽

Cited By ~ 2

Author(s):

Fan Tian ◽

Steven Siyao Meng ◽

Peiyuan Qiu

Keyword(s):

Depressive Symptoms ◽

Longitudinal Study ◽

Life Course ◽

Childhood Adversities ◽

The Life Course

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Effect of pregnancy intention, postnatal depressive symptoms and social support on early childhood stunting: findings from India

BMC Pregnancy and Childbirth ◽

10.1186/s12884-016-0909-9 ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 8

Author(s):

Ashish Kumar Upadhyay ◽

Swati Srivastava

Keyword(s):

Social Support ◽

Early Childhood ◽

Depressive Symptoms ◽

Pregnancy Intention ◽

Postnatal Depressive Symptoms ◽

Childhood Stunting

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Every Night and Every Morn: Effect of Variation in CLOCK Gene on Depression Depends on Exposure to Early and Recent Stress

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.687487 ◽

2021 ◽

Vol 12 ◽

Author(s):

Dorka Gyorik ◽

Nora Eszlari ◽

Zsofia Gal ◽

Dora Torok ◽

Daniel Baksa ◽

...

Keyword(s):

Depressive Symptoms ◽

Linkage Disequilibrium ◽

Life Events ◽

Negative Life Events ◽

Population Sample ◽

Brief Symptom Inventory ◽

Additive Models ◽

Outcome Variable ◽

Childhood Adversities ◽

Increased Risk

The role of circadian dysregulation is increasingly acknowledged in the background of depressive symptoms, and is also a promising treatment target. Similarly, stress shows a complex relationship with the circadian system. The CLOCK gene, encoding a key element in circadian regulation has been implicated in previous candidate variant studies in depression with contradictory findings, and only a few such studies considered the interacting effects of stress. We investigated the effect of CLOCK variation with a linkage-disequilibrium-based clumping method, in interaction with childhood adversities and recent negative life events, on two phenotypes of depression, lifetime depression and current depressive symptoms in a general population sample.Methods: Participants in NewMood study completed questionnaires assessing childhood adversities and recent negative life events, the Brief Symptom Inventory to assess current depressive symptoms, provided data on lifetime depression, and were genotyped for 1054 SNPs in the CLOCK gene, 370 of which survived quality control and were entered into linear and logistic regression models with current depressive symptoms and lifetime depression as the outcome variable, and childhood adversities or recent life events as interaction variables followed by a linkage disequilibrium-based clumping process to identify clumps of SNPs with a significant main or interaction effect.Results: No significant clumps with a main effect were found. In interaction with recent life events a significant clump containing 94 SNPs with top SNP rs6825994 for dominant and rs6850524 for additive models on current depression was identified, while in interaction with childhood adversities on current depressive symptoms, two clumps, both containing 9 SNPs were found with top SNPs rs6828454 and rs711533.Conclusion: Our findings suggest that CLOCK contributes to depressive symptoms, but via mediating the effects of early adversities and recent stressors. Given the increasing burden on circadian rhythmicity in the modern lifestyle and our expanding insight into the contribution of circadian disruption in depression especially as a possible mediator of stress, our results may pave the way for identifying those who would be at an increased risk for depressogenic effects of circadian dysregulation in association with stress as well as new molecular targets for intervention in stress-related psychopathologies in mood disorders.

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The Association of Maternal Depressive Symptoms, Family Relationships and Social Support with Parenting Behaviors During Early Childhood

Korea Journal of Child Care and Education ◽

10.37918/kce.2019.05.116.65 ◽

2019 ◽

Vol 116 ◽

pp. 65-90

Author(s):

Jongil Yuh

Keyword(s):

Social Support ◽

Early Childhood ◽

Depressive Symptoms ◽

Family Relationships ◽

Parenting Behaviors ◽

Maternal Depressive Symptoms

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Childhood Adversities, Midlife Health, and Elder Abuse Victimization: A Longitudinal Analysis Based on Cumulative Disadvantage Theory

The Journals of Gerontology Series B ◽

10.1093/geronb/gbaa095 ◽

2020 ◽

Author(s):

Scott D Easton ◽

Jooyoung Kong

Keyword(s):

Depressive Symptoms ◽

Physical Health ◽

Cognitive Functioning ◽

Elder Abuse ◽

Late Life ◽

Health Concern ◽

Outcome Variable ◽

Middle Adulthood ◽

Childhood Adversities ◽

Cumulative Disadvantage

Abstract Objectives Elder abuse victimization is increasingly recognized as a pressing public health concern. However, few empirical studies have investigated whether early life course adversities and midlife sequelae heighten risks for abuse in late life. Guided by cumulative disadvantage theory, the current study examined whether compromised health in middle adulthood (physical, psychological, cognitive) mediates the association between child abuse and elder abuse. Method This secondary analysis was based on data from the Wisconsin Longitudinal Study, a population-based, multi-wave dataset. We analyzed responses from 5,968 participants (mean age = 71 years; 54% female) on adapted versions of standardized measures: elder abuse victimization (outcome variable), childhood adversities (independent variable), and midlife health (physical health, depressive symptoms, cognitive functioning; mediator variables). Serial multiple mediation models were conducted, controlling for background characteristics. Results Rates for any elder abuse and child adversities were, respectively, 16.34% and 47.98%. Multivariate analyses supported the cumulative disadvantage hypothesis. Childhood adversities (0.11, p < .001) and midlife health (physical, −0.10, p < .05; depressive symptoms, 0.09, p < .001; cognitive functioning, 0.02, p < .05) had significant direct effects on elder abuse victimization. Childhood adversities also had an indirect effect on elder abuse through physical health (0.002, p < .05) and depressive symptoms (0.01, p < .001), both in serial. Discussion This innovative study advances our understanding mechanisms through which childhood trauma influences abuse in late life. Boosting health in middle adulthood could help prevent elder abuse. Other implications for clinical practice, treatment, and future research on elder abuse are discussed.

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