Network parameters and biocompatibility of p(2-hydroxyethyl methacrylate/itaconic acid/oligo(ethylene glycol) acrylate) dual-responsive hydrogels

2013 ◽  
Vol 49 (10) ◽  
pp. 3223-3233 ◽  
Author(s):  
M. Micic ◽  
E. Suljovrujic
Keyword(s):  
Ethylene Glycol ◽  
Itaconic Acid ◽  
Hydroxyethyl Methacrylate ◽  
Network Parameters ◽  
Dual Responsive ◽  
Responsive Hydrogels

Dual-responsive nanogels based on oligo(ethylene glycol) methacrylates and acidic co-monomers

Soft Matter ◽  
2019 ◽  
Vol 15 (47) ◽  
pp. 9700-9709 ◽  
Author(s):  
Micaela A. Macchione ◽  
M. Florencia Sacarelli ◽  
Ana C. Racca ◽  
Catalina Biglione ◽  
Graciela M. Panzetta-Dutari ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Ethylene Glycol ◽  
Itaconic Acid ◽  
Biomedical Applications ◽  
Dual Responsive

Monodispersed nanogels based on oligo(ethylene glycol) methacrylates and acrylic acid or itaconic acid as candidates for biomedical applications.

scholarly journals Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2204
Author(s):  
Zhidan Wang ◽  
Jie Wu ◽  
Xiaoyu Shi ◽  
Fei Song ◽  
Wenli Gao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Ethylene Glycol ◽  
Crosslinking Agent ◽  
Ethylene Glycol Dimethacrylate ◽  
Poly Lactic Acid ◽  
Chemical Crosslinking ◽  
Glycol Dimethacrylate ◽  
Dual Responsive ◽  
Responsive Hydrogels ◽  
Physical Crosslinking

Physical crosslinking and chemical crosslinking were used to further improve the mechanical properties and stability of the gel. A temperature/pH dual sensitive and double-crosslinked gel was prepared by the stereo-complex of HEMA-PLLA20 and HEMA-PDLA20 as a physical crosslinking agent, ethylene glycol dimethacrylate (EGDMA) as a chemical crosslinking agent, and azodiisobutyronitrile (AIBN) as an initiator for free radical polymerization. This paper focused on the performance comparison of chemical crosslinked gel, a physical crosslinked gel, and a dual crosslinked gel. The water absorption, temperature, and pH sensitivity of the three hydrogels were studied by a scanning electron microscope (SEM) and swelling performance research. We used a thermal analysis system (TGA) and dynamic viscoelastic spectrometer to study thermal properties and mechanical properties of these gels. Lastly, the in vitro drug release behavior of double-crosslinked hydrogel loaded with doxorubicin under different conditions was studied. The results show that the double-crosslinked and temperature/pH dual responsive hydrogels has great mechanical properties and good stability.

Using dioxane and water as mixed solvents to prepare pH and temperature dual responsive poly(N-isopropyl acrylamide-co-itaconic acid) hydrogels

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Youdao Ling ◽  
Mangeng Lu
Keyword(s):  
Itaconic Acid ◽  
Mixed Solvents ◽  
Chemical Compositions ◽  
Temperature Responsive ◽  
Dual Responsive ◽  
Isopropyl Acrylamide ◽  
Equilibrium Swelling ◽  
Chain Conformations ◽  
Responsive Hydrogels ◽  
Equilibrium Swelling Ratios

AbstractpH and temperature dual responsive hydrogels based on itaconic acid (IA) and N-isopropylacrylamide (NIPAAm) were prepared by means of water and dioxane as mixed solvents. The chemical compositions, structures and morphologies of these hydrogels were characterized by FTIR, TGA and SEM, and their pH and temperature responsive behaviours were investigated through equilibrium swelling ratios, deswelling and reswelling kinetics. The results showed the hydrogels fabricated in this condition had expanded chain conformations and macroporous network structures, and exhibited the larger swelling ratios as well as improved deswelling/reswelling dynamics.

scholarly journals Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels

2011 ◽  
Vol 65 (6) ◽  
pp. 675-685 ◽  
Author(s):  
Sava Dobic ◽  
Jovana Jovasevic ◽  
Marija Vojisavljevic ◽  
Simonida Tomic
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Cell Viability ◽  
Itaconic Acid ◽  
Hydroxyethyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Swelling Properties ◽  
Swelling Studies ◽  
Poly Ethylene

In this study novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical crosslinking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revails that the cell viability of all samples was the range of 97?100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe ,with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials.

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