scholarly journals Nanocarriers based on block copolymers of l-proline and lactide: the effect of core crosslinking versus its pH-sensitivity on their cellular uptake

2021 ◽  
pp. 110572
Author(s):  
Marek Brzeziński ◽  
Bartłomiej Kost Investigatio ◽  
Weronika Gonciarz ◽  
Agnieszka Krupa ◽  
Marta Socka ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Cellular Uptake ◽  
Ph Sensitivity

scholarly journals Amphiphilic block copolymers enhance the cellular uptake of DNA molecules through a facilitated plasma membrane transport

2010 ◽  
Vol 39 (4) ◽  
pp. 1610-1622 ◽  
Author(s):  
Raphaël Chèvre ◽  
Olivier Le Bihan ◽  
Fanny Beilvert ◽  
Benoit Chatin ◽  
Benoit Barteau ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Block Copolymers ◽  
Membrane Transport ◽  
Cellular Uptake ◽  
Amphiphilic Block Copolymers ◽  
Dna Molecules

scholarly journals Controlling Nanoemulsion Surface Chemistry with Poly(2-Oxazoline) Amphiphiles

2018 ◽  
Author(s):  
Daniel A. Estabrook ◽  
Amanda F. Ennis ◽  
Rachael Day ◽  
Ellen Sletten
Keyword(s):  
Block Copolymers ◽  
Surface Chemistry ◽  
Physicochemical Properties ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Covalent Modification ◽  
Dynamic Materials ◽  
Structure Activity ◽  
Modified Surface ◽  
Surface Chemistries

Emulsions are dynamic materials that have been extensively employed within pharmaceutical, food and cosmetics industries. However, their use beyond conventional applications has been hindered by difficulties in surface functionalization, and an inability to selectively control physicochemical properties. Here, we employ custom poly(2-oxazoline) block copolymers to overcome these limitations. We demonstrate that poly(2-oxazoline) copolymers can effectively stabilize nanoscale droplets of hydrocarbon and perfluorocarbon in water. The living polymerization allows for the incorporation of chemical handles into the surfactants such that covalent modification of the emulsion surfaces can be performed. Through post-emulsion modification, we are able to access nanoemulsions with modified surface chemistries, yet consistent sizes. By decoupling size and surface charge, we explore structure-activity relationships involving the cellular uptake of nanoemulsions.

scholarly journals Multiresponsive micellar block copolymers from 2-vinylpyridine and dialkylvinylphosphonates with a tunable lower critical solution temperature

RSC Advances ◽  
2016 ◽  
Vol 6 (82) ◽  
pp. 78750-78754 ◽  
Author(s):  
F. Adams ◽  
P. T. Altenbuchner ◽  
P. D. L. Werz ◽  
B. Rieger
Keyword(s):  
Block Copolymers ◽  
Lower Critical Solution Temperature ◽  
Ph Sensitivity ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Temperature Range

Tailor-made, multi-responsive micellar AB and ABB′ block copolymers show a pH-sensitivity and a tunable LCST within an expanded temperature range.

The synthesis and comparison of poly(methacrylic acid)–poly(ε-caprolactone) block copolymers with and without symmetrical disulfide linkages in the center for enhanced cellular uptake

RSC Advances ◽  
2016 ◽  
Vol 6 (79) ◽  
pp. 75092-75103 ◽  
Author(s):  
Yu-Sheng Liu ◽  
Shih-Jer Huang ◽  
Xiao-Shan Huang ◽  
Yi-Ting Wu ◽  
Hsuan-Ying Chen ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Cellular Uptake ◽  
Methacrylic Acid ◽  
Ph Sensitive ◽  
Disulfide Linkage ◽  
Disulfide Linkages ◽  
Sensitive Characteristics ◽  
Self Assembled ◽  
Symmetrical Disulfide

A self-assembled poly(methacrylic acid)–poly(ε-caprolactone) block copolymer with a disulfide linkage, PMAA-b-PCL-SS-PCL-b-PMAA, was synthesized for enhanced cellular uptake due to a reduction response to GSH and pH-sensitive characteristics.

Evaluation of various block copolymers for micelle formation and brain drug delivery: In vitro characterization and cellular uptake studies

2016 ◽  
Vol 36 ◽  
pp. 120-129 ◽  
Author(s):  
Zerrin Sezgin-bayindir ◽  
Ahmet Doğan Ergin ◽  
Mahmut Parmaksiz ◽  
Ayse Eser Elcin ◽  
Yasar Murat Elcin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Cellular Uptake ◽  
Micelle Formation ◽  
Brain Drug Delivery ◽  
In Vitro Characterization ◽  
Uptake Studies

Polymeric micelles using pseudo-amphiphilic block copolymers and their cellular uptake

2011 ◽  
Vol 21 (8) ◽  
pp. 2555 ◽  
Author(s):  
Massimo Benaglia ◽  
Angelo Alberti ◽  
Enzo Spisni ◽  
Alessio Papi ◽  
Emanuele Treossi ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Cellular Uptake ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers

scholarly journals Controlling Nanoemulsion Surface Chemistry with Poly(2-Oxazoline) Amphiphiles

2018 ◽  
Author(s):  
Daniel A. Estabrook ◽  
Amanda F. Ennis ◽  
Rachael Day ◽  
Ellen Sletten
Keyword(s):  
Block Copolymers ◽  
Surface Chemistry ◽  
Physicochemical Properties ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Covalent Modification ◽  
Dynamic Materials ◽  
Structure Activity ◽  
Modified Surface ◽  
Surface Chemistries

Emulsions are dynamic materials that have been extensively employed within pharmaceutical, food and cosmetics industries. However, their use beyond conventional applications has been hindered by difficulties in surface functionalization, and an inability to selectively control physicochemical properties. Here, we employ custom poly(2-oxazoline) block copolymers to overcome these limitations. We demonstrate that poly(2-oxazoline) copolymers can effectively stabilize nanoscale droplets of hydrocarbon and perfluorocarbon in water. The living polymerization allows for the incorporation of chemical handles into the surfactants such that covalent modification of the emulsion surfaces can be performed. Through post-emulsion modification, we are able to access nanoemulsions with modified surface chemistries, yet consistent sizes. By decoupling size and surface charge, we explore structure-activity relationships involving the cellular uptake of nanoemulsions.

scholarly journals Novel multi-responsive polymer magnetic microgels with folate or methyltetrahydrofolate ligand as anticancer drug carriers

RSC Advances ◽  
2017 ◽  
Vol 7 (17) ◽  
pp. 10333-10344 ◽  
Author(s):  
Yunli Hu ◽  
Weijun Liu ◽  
Fanhong Wu
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Cellular Uptake ◽  
Hela Cells ◽  
Targeted Delivery ◽  
Drug Carriers ◽  
Ph Sensitivity ◽  
Responsive Polymer ◽  
L02 Cells

MP-PNAAEF or MP-PNAAEM microgels exhibiting good thermo- and pH-sensitivity have been prepared for targeted delivery to FR(+) cancer cells. The DOX-loaded microgels showed higher cellular uptake by the Hela cells, but not by the L02 cells.

The Core Composition of DNA Block Copolymer Micelles Dictates DNA Hybridization Properties, Nuclease Stabilities, and Cellular Uptake Efficiencies

Nanoscale ◽  
2021 ◽  
Author(s):  
Chan-Jin Kim ◽  
Ga-Hyun Kim ◽  
Eun Hye Jeong ◽  
Hyukjin Lee ◽  
So-Jung Park
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Cellular Uptake ◽  
Molecular Interactions ◽  
Dna Hybridization ◽  
Hydrophobic Core ◽  
The Core ◽  
Core Composition ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Here, we report how the nature of the hydrophobic core affects molecular interactions of DNA block copolymer assemblies. Three different amphiphilic DNA block copolymers, DNA-b-polystyrene (DNA-b-PS), DNA-b-poly(2-vinylpyridine) (DNA-b-P2VP), and DNA-b-poly(methyl...

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