Fecundity and bipolar spectrum disorder

2016 ◽  
Vol 33 (S1) ◽  
pp. S342-S343
Author(s):  
J. Vieira ◽  
M. Salta ◽  
B. Barata ◽  
J. Nogueira ◽  
R. Sousa ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Statistical Significance ◽  
Well Being ◽  
Spectrum Disorder ◽  
Psychiatric Disease ◽  
Bipolar Spectrum ◽  
Number Of Children ◽  
Marriage Rates ◽  
Bipolar Spectrum Disorder ◽  
Competing Interest

IntroductionFertility and fecundity are usually considered signs of social and emotional well-being. Bipolar disorder (BD) is a prevalent psychiatric disease that influences the individual's life style and behaviours. Some studies have addressed the issue of fecundity among women with bipolar disorder but few have focused on determining the differences between disease subtypes, which is expected, taking into account the studied differences in demographic measures.ObjectivesTo examine the fecundity of a population of women with bipolar disorder.AimThe aim of this study is to compare the fecundity among women diagnosed with subtypes I to IV of BD, according to Akiskal's bipolar spectrum disorder classification.MethodsA total of 108 female outpatients were divided into four groups. We analyzed number of offspring and demographic features between patients with different subtypes of BD using multivariate analyses.ResultsOur results showed a significantly higher average number of children for BD IV patients when compared with BD I patients. Although not reaching statistical significance, BD I patients had less offspring than BD II and BD III patients. BD I patients had lower marriage rates compared to the other groups.ConclusionsOur results suggest that the subtype of bipolar disorder influences fecundity and behaviours, as is expressed by the lower number of marriages seen in BD I patients. We found that fecundity is significantly impaired among BD I patients, which may imply that female with more severe disorders are less likely to become parents. Fecundity is higher among BD IV patients, which makes a way to speculate about the adaptive role of hyperthimic temperamental traits.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Aripiprazole in the Treatment of Pediatric Bipolar Disorder: A Systematic Chart Review

CNS Spectrums ◽  
2005 ◽  
Vol 10 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Joseph Biederman ◽  
Mary Ann McDonnell ◽  
Janet Wozniak ◽  
Thomas Spencer ◽  
Megan Aleardi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Global Impression ◽  
Chart Review ◽  
Spectrum Disorder ◽  
Pediatric Bipolar Disorder ◽  
Bipolar Spectrum ◽  
Manic Symptoms ◽  
Bipolar Spectrum Disorder ◽  
Daily Dose ◽  
Clinical Global Impression Improvement

ABSTRACTBackgroundPediatric bipolar diorder is a serious neuropsychiatric disorder asociated with high levels of morbidity and disabilty.ObjectiveThis is a systematic chart review of all outpatient youth with the diagnosis of bipolar disorder and bipolar spectrum disorder treated with aripiprazole either alone or as add-on to ongoing treatments.MethodMedical records were reviewed to identify all subjects with bipolar and bipolar spectrum disorder prescribed aripiprazole in our clinic. During the chart review, the Clinical Global Impression scale was completed by the treating clinicians to determine usefullness.ResultsForty-one youths (mean age±SD: 11.4±3.5 years) with bipolar spectrum disorder who had been treated with aripiprazole were identified. These children received a mean daily dose of aripiprazole 16.0±7.9 mg over an average of 4.6 months. Using a Clinical Global Impression-Improvement scale score of <2 (very much/much improved) to define robust improvement, 71% showed improvement in manic symptoms. Treatment with aripiprazole was well tolerated.ConclusionThis study suggests that aripiprazole may be a useful and well-tolerated treatment for youth with bipolar disorder and it supports the need for controlled clinical trials of this compound in juvenile mania.

scholarly journals Mother-to-Infant Bonding in Women With a Bipolar Spectrum Disorder

2021 ◽  
Vol 9 ◽  
Author(s):  
Myrthe G. B. M. Boekhorst ◽  
Annemerle Beerthuizen ◽  
Manon Hillegers ◽  
Victor J. M. Pop ◽  
Veerle Bergink
Keyword(s):  
Bipolar Disorder ◽  
Pregnant Women ◽  
Population Based ◽  
Spectrum Disorder ◽  
Control Group ◽  
Bipolar Spectrum ◽  
Bipolar Spectrum Disorder ◽  
Not Otherwise Specified ◽  
Increased Risk ◽  
History Of

Purpose: Offspring of mothers with a bipolar disorder are at high-risk for impaired developmental outcomes and psychopathology (e. g., mood, anxiety, sleep disorders) later in life. This increased risk of psychopathology is not only because of genetic vulnerability, but environmental factors may play an important role as well. The often long and debilitating mood episodes of mothers with bipolar disorder might hamper their qualities as a caregiver and may impact the child. We examined early mother-to-infant bonding 1 year postpartum in mothers with bipolar spectrum disorder as compared to mothers of the general population. The association between mother-to-infant bonding and the type of bipolar spectrum diagnosis (bipolar I, bipolar II, bipolar Not Otherwise Specified) as well as relapse within 12 months postpartum was also assessed.Methods: In total, 75 pregnant women with a bipolar spectrum disorder participated in the current study. The participants were included in a longitudinal cohort study of women with bipolar spectrum disorder and were prospectively followed from pregnancy until 1 year postpartum. Mother-to-infant bonding was assessed using the Pre- and Postnatal Bonding Scale. A longitudinal population-based cohort of 1,419 pregnant women served as the control group. Multiple linear regression analyses were used to assess the association between bipolar spectrum disorder and mother-to-infant bonding scores, controlling for several confounders.Results: Women with bipolar spectrum disorder perceived the bonding with their child as less positive compared to the control group. The type of bipolar spectrum disorder was not associated with poorer bonding scores. Relapse during the 1st year after delivery also did not affect bonding scores in women with bipolar spectrum disorder.Conclusions: Our findings could imply that women with bipolar spectrum disorder are more vulnerable to impairments in bonding due to the nature of their psychopathology, regardless of the occurrence of postpartum relapse. Careful follow-up including monitoring of mother-to-infant bonding of pregnant women with a history of bipolar spectrum disorder should be a standard to this vulnerable group of women. In addition, regardless of severity and mood episode relapse, an intervention to improve bonding could be beneficial for all mothers with bipolar spectrum disorder and their newborns.

Bipolar illness

2019 ◽  
pp. 315-360
Author(s):  
David Semple ◽  
Roger Smyth
Keyword(s):  
Bipolar Disorder ◽  
Manic Episode ◽  
Spectrum Disorder ◽  
Bipolar Spectrum ◽  
Pharmacological Interventions ◽  
Bipolar Illness ◽  
Bipolar Spectrum Disorder ◽  
Clinical Presentations ◽  
Depressive Episodes

This chapter covers bipolar illness. Definitions of mania and a manic episode are defined, as well as hypomania and hypomanic episodes. Bipolar spectrum disorder and different forms of bipolar disorder are classified, clinical presentations and notes described, and management principles discussed. Treatment of acute manic episodes and depressive episodes are covered, including prophylaxis and psychotherapeutic and pharmacological interventions (lithium, valproate, carbamazepine, and lamotrigine).

scholarly journals ANK3 gene expression in bipolar disorder and schizophrenia

2014 ◽  
Vol 205 (3) ◽  
pp. 244-245 ◽  
Author(s):  
Katrine Verena Wirgenes ◽  
Martin Tesli ◽  
Elin Inderhaug ◽  
Lavinia Athanasiu ◽  
Ingrid Agartz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bipolar Disorder ◽  
Psychotic Disorders ◽  
Spectrum Disorder ◽  
Bipolar Spectrum ◽  
Schizophrenia Spectrum Disorder ◽  
Cis Acting ◽  
Bipolar Spectrum Disorder ◽  
Schizophrenia Spectrum ◽  
Underlying Mechanisms

SummaryANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive. Here, we show that ANK3 gene expression in blood is significantly increased in bipolar disorder and schizophrenia compared with healthy controls. Additionally, we identified potential cis-acting expression quantitative trait loci located close to the transcription start site of one of the isoforms of the gene. These findings suggest that ANK3 mRNA is an interesting marker for further investigation of the underlying mechanisms in psychotic disorders.

scholarly journals Self-reported morbidities, nutritional characteristics, and associated factors in institutionalized and non-institutionalized older adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Abdelhafid Benksim ◽  
Rachid Ait Addi ◽  
Elhassania Khalloufi ◽  
Aziz Habibi ◽  
Mohamed Cherkaoui
Keyword(s):  
Older Adults ◽  
Health Insurance ◽  
Nutritional Status ◽  
Statistical Significance ◽  
Well Being ◽  
Public Institution ◽  
Subjective Well Being ◽  
Number Of Children ◽  
Significant Difference ◽  
Nutritional Characteristics

Abstract Background As the world’s population ages and people live longer, it seems important to ensure that older people have a good quality of life and positive subjective well-being. The objective of this study is to determine socio-economic, health and nutritional characteristics of institutionalized and non-institutionalized elders in the province of Marrakech. Methods This study was conducted among 368 older adults in the province of Marrakech between March 2017 and June 2019. Of all participants, 180 older adults reside in a public institution and 188 of them live in their own homes. Data on health conditions, nutritional status, functional and socio-economic characteristics were collected. Data was analyzed using SPSS Statistics for Windows, Version 16.0. Statistical significance was set at p < 0.05. Results Institutionalized elders were illiterate (80.0%), had low incomes (95.5%), and unmarried (73.3%), they reported also no children (56.1%) and no health insurance (98.9%). Institutional residents suffered from malnutrition (22.2%), hearing impairments (35.6%) and severe edentulism (43.3%). There was no significant difference between both groups on daily activities and depression. A multivariate analysis identified a model with three significant variables associated with non-institutionalized elders: health insurance (P = 0.001; OR = 107.49), number of children (P = 0.001; OR = 1.74) and nutritional status (p = 0.001; OR = 3.853). Conclusions This study shows that the institutionalization of older adults is considerably induced by various factors such as nutritional problems, lack of health insurance and family structure. To mitigate the effects of this phenomenon, home care strategies and preventive actions should be implemented to delay the institutionalization of older adults and therefore keep them socially active in their own homes.

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