Prevalence and clinical correlates of sensory phenomena in obsessive compulsive disorder

IntroductionA substantial number of patients suffering from obsessive compulsive disorder (OCD) report a subjective distressing experience prior to the repetitive behavior, known as sensory phenomena(SP).ObjectivesNeed to systematically evaluate SP and the clinical correlates in OCD.AimsAssess prevalence of SP and clinical correlates in OCD.MethodsSubjects (n = 71) fulfilling the criteria for DSM IV-TR OCD were recruited consecutively from a specialty OCD clinic in Southern India and were assessed using the Yale brown obsessive and compulsive scale (YBOCS), dimensional Yale-Brown obsessive compulsive scale (D-YBOCS) and the University of São Paulo Sensory Phenomena Scale (USP-SPS).ResultsThe prevalence of the SP was found to be 50.7%. Prevalence of SP is significantly greater in the patients with early age of onset (P = 0.47). In subtypes of SP, Tactile was 12.7%, “just right” for look was 26.8%, “just right” for sound was 9.9%, “just right” for feeling was 16.9%, feeling of incompleteness leading to repetitive behavior was 22.5%, “energy release” sensation leading to repetitive behavior was 4.2% and “urge only” leading to repetitive behavior was 11.3%. SP was found to have significant correlation with symmetry/ordering/arranging/counting dimension (P = 0.003). Significant positive correlation existed between SP severity and the severity of the compulsions (P = 0.02).ConclusionConsidering its high prevalence in OCD, it might be useful to incorporate SP assessment during the routine clinical assessment of OCD. It might warrant a place in the phenomenological and nosological description of OCD. Additionally, the neurobiological correlates of SP need to be explored.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Blocking Tics in Gilles de la Tourette Syndrome

Frontiers in Neurology ◽

10.3389/fneur.2021.686785 ◽

2021 ◽

Vol 12 ◽

Author(s):

Justyna Kaczyńska ◽

Piotr Janik

Keyword(s):

Obsessive Compulsive Disorder ◽

Tourette Syndrome ◽

Age Of Onset ◽

Severe Form ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Clinical Correlates ◽

Clinical Associations ◽

Motor Acts

Introduction: Patients with Gilles de la Tourette syndrome (GTS) may experience blocking tics (BTs) defined as recurrent, brief cessations of motor acts. The aim of this study was to assess the prevalence, age of onset, and clinical correlates of BTs in GTS patients.Materials and Methods: We performed a one-time registration study in a cohort of 195 consecutive GTS patients aged 5–66 years (mean age: 15.0 ± 9.2; 47 females, 24.1%). All patients were personally interviewed and examined.Results: At least one BT occurred at some point in the lifetime of 73 patients (37.4%) with a mean age of onset of 10.4 ± 5.9 years. BTs occurred an average of 4.8 ± 5.3 years after tic onset. The most common BT was cessation of walking (n = 59, 80.8%), followed by speech (n = 19, 26.0%), running (n = 18, 24.7%), and writing (n = 9, 12.3%). Most of the patients (n = 52, 71.2%) reported cessation of only one activity. Clinical associations of BTs included more severe tics, overall greater number of tics, and, to a lesser extent, higher age at evaluation and comorbid obsessive-compulsive disorder.Conclusions: BTs represent complex tics, early and common symptoms of GTS, and are associated with a more severe form of GTS.

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Paroxetine concentrations in obsessive-compulsive disorder: Support for a therapeutic interval

European Psychiatry ◽

10.1016/j.eurpsy.2017.02.245 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S322-S322

Author(s):

M.B. Humble ◽

M. Reis

Keyword(s):

Obsessive Compulsive Disorder ◽

Clinical Symptoms ◽

Global Evaluation ◽

Obsessive Compulsive ◽

Double Blind ◽

Compulsive Disorder ◽

Number Of Patients ◽

The Mean ◽

Competing Interest ◽

L 13

IntroductionPrevious studies of concentrations of serotonin reuptake inhibitors (SRIs) versus therapeutic efficacy have yielded inconsistent results. Even if the relationships between the individual's serotonergic system and the clinical symptoms of obsessive-compulsive disorder (OCD) are poorly understood, the SRIs are consistently effective in OCD. However, studies on SRI concentrations in OCD treatment are rare.Objectives/aimsTo identify possible links between paroxetine concentrations and anti-obsessive response.MethodsIn a randomised, double-blind trial, comparing clomipramine, paroxetine and placebo in OCD treatment, serum paroxetine levels were measured after 1 week and after 4 weeks of treatment in 18 patients. Anti-obsessive response was assessed with Yale-Brown obsessive compulsive scale (Y-BOCS) and patients’ global evaluation (PGE), after 12 weeks of treatment.ResultsSerum paroxetine concentrations after 4 weeks suggested a therapeutic interval between 50 and 240 nmol/L (13–63 ng/mL). The mean Y-BOCS decrease was 54% inside versus 7% outside this interval (t = 3.96; P = 0.0011).ConclusionsParoxetine levels seemingly predicted clinical outcome. Studies with a greater number of patients are necessary in order to confirm this finding and to discern whether it is useful in clinical practice.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Delayed Sleep Phase in Severe Obsessive-Compulsive Disorder: A Systematic Case-Report Survey

CNS Spectrums ◽

10.1017/s1092852900016576 ◽

2008 ◽

Vol 13 (5) ◽

pp. 406-413 ◽

Cited By ~ 36

Author(s):

Suman Mukhopadhyay ◽

Naomi A. Fineberg ◽

Lynne M. Drummond ◽

Joanne Turner ◽

Sarah White ◽

...

Keyword(s):

Case Report ◽

Obsessive Compulsive Disorder ◽

Age Of Onset ◽

Case Reports ◽

Obsessive Compulsive ◽

Sleep Phase ◽

Compulsive Disorder ◽

Number Of Patients ◽

Delayed Sleep Phase ◽

Delayed Sleep

ABSTRACTIntroduction:To study the prevalence of delayed sleep phase (DSP) in a cohort of inpatients with severe obsessive-compulsive disorder (OCD) and to identify clinical and demographic correlates.Methods:A systematic retrospective case-report study of consecutive OCD admissions to a specialist inpatient unit from January 1995 to December 2003. Nursing and medical records of sleep, demographic, clinical, and other relevant details were recorded.Results:Of 194 eligible consecutive case reports, 187 were located, and nursing and medical reports of sleep were identified in all 187 (100%). Thirty-three patients (17.6%) fulfilled operationally defined criteria for DSP after exclusion of possible confounding factors. All the patients with DSP were unemployed. Phase-shifted patients were significantly younger than non-shifted patients (P=.019) and reported an earlier age of onset of their OCD (P=.005). There was a non-significant trend toward more severe OCD in the phase-shifted group, but they were not more depressed than their non-shifted counterparts.Conclusion:A substantial number of patients with severe, enduring OCD also suffer with DSP, which seems to be specifically linked to OCD as opposed to comorbid depression. Clarification of the etiology within DSP and its interaction with core OCD symptoms on clinical function and disability may identify new treatment targets. To this end, further studies of sleep in OCD using actigraphy and biological measures are indicated.

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Age of Onset for Obsessive-Compulsive Disorder

PsycEXTRA Dataset ◽

10.1037/e334472004-014 ◽

1990 ◽

Cited By ~ 2

Author(s):

W. E. Minichiello ◽

L. Baer ◽

M. A. Jenike ◽

A. Holland

Keyword(s):

Obsessive Compulsive Disorder ◽

Age Of Onset ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Symmetry Dimension in Obsessive–Compulsive Disorder: Prevalence, Severity and Clinical Correlates

Journal of Clinical Medicine ◽

10.3390/jcm10020274 ◽

2021 ◽

Vol 10 (2) ◽

pp. 274

Author(s):

Aline P. Vellozo ◽

Leonardo F. Fontenelle ◽

Ricardo C. Torresan ◽

Roseli G. Shavitt ◽

Ygor A. Ferrão ◽

...

Keyword(s):

Logistic Regression ◽

Obsessive Compulsive Disorder ◽

Clinical Sample ◽

Cross Sectional Study ◽

Obsessive Compulsive ◽

Chi Square ◽

Cross Sectional ◽

Compulsive Disorder ◽

Clinical Correlates ◽

Axis I

Background: Obsessive–compulsive disorder (OCD) is a very heterogeneous condition that frequently includes symptoms of the “symmetry dimension” (i.e., obsessions and/or compulsions of symmetry, ordering, repetition, and counting), along with aggressive, sexual/religious, contamination/cleaning, and hoarding dimensions. Methods: This cross-sectional study aimed to investigate the prevalence, severity, and demographic and clinical correlates of the symmetry dimension among 1001 outpatients from the Brazilian Research Consortium on Obsessive–Compulsive Spectrum Disorders. The main assessment instruments used were the Dimensional Yale–Brown Obsessive–Compulsive Scale, the Yale–Brown Obsessive–Compulsive Scale, the USP-Sensory Phenomena Scale, the Beck Depression and Anxiety Inventories, the Brown Assessment of Beliefs Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. Chi-square tests, Fisher’s exact tests, Student’s t-tests, and Mann–Whitney tests were used in the bivariate analyses to compare patients with and without symptoms of the symmetry dimension. Odds ratios (ORs) with confidence intervals and Cohen’s D were also calculated as effect size measures. Finally, a logistic regression was performed to control for confounders. Results: The symmetry dimension was highly prevalent (86.8%) in this large clinical sample and, in the logistic regression, it remained associated with earlier onset of obsessive–compulsive symptoms, insidious onset of compulsions, more severe depressive symptoms, and presence of sensory phenomena. Conclusions: A deeper knowledge about specific OCD dimensions is essential for a better understanding and management of this complex and multifaceted disorder.

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